An fMRI study on the groove experience in Parkinson's disease

Victor Pando-Naude, Tomas Matthews, Andreas Højlund, Erik Johnsen, Eduardo Garza Villarreal, Maria Witek, Ole Heggli, Boris Kleber, Virginia Penhune, Peter Vuust

Publikation: KonferencebidragPaperForskningpeer review

56 Downloads (Pure)

Abstract

Music activates brain regions associated with pleasure and reward and can create an impulse to move in time with the beat. This study tested the hypothesis that the pleasurable urge to move to music (PLUMM), often referred to as a groove experience, relies on the interaction between auditory, motor, and reward regions in the brain, with the basal ganglia (BG) loops playing a central role. Brain functional connectivity (FC) of healthy controls (HC) and participants with Parkinson's disease (PD), a movement disorder resulting from dopaminergic dysfunctions in the BG, was compared using fMRI. Participants listened to musical sequences with varying rhythmic complexity (isochronous, low, medium, high) and rated their experienced PLUMM. FC correlates were analyzed as a function of each rhythmic condition using generalized psychophysiological interactions with a seed-based approach. Behaviorally, HC preferred medium complexity, while PD preferred low. Regarding FC, HC showed significant correlations exclusively between auditory areas within and between hemispheres while listening to isochronous and high complexity rhythms. While listening to low and medium complexities, HC showed additional correlations between auditory cortices and supplementary motor areas, stronger with medium. PD participants showed significant correlations only between posterior auditory cortices during isochronous rhythms. Low and medium complexities in PD also showed correlations between auditory cortices and supplementary motor area, stronger with low. High complexity in PD showed anticorrelated FC between auditory, sensorimotor, and cingulate cortices. These results support models implicating dopamine in PLUMM and suggest that dopamine dysregulation within cortico-striatal circuits disrupts beat-and meter-based predictive processes.
OriginalsprogEngelsk
Publikationsdato2023
DOI
StatusUdgivet - 2023
BegivenhedInterntational Conference of Music Perception and Cognition ICMPC17-APSCOM - Tokyo, Japan
Varighed: 24 aug. 202328 aug. 2023

Konference

KonferenceInterntational Conference of Music Perception and Cognition ICMPC17-APSCOM
Land/OmrådeJapan
ByTokyo
Periode24/08/202328/08/2023

Fingeraftryk

Dyk ned i forskningsemnerne om 'An fMRI study on the groove experience in Parkinson's disease'. Sammen danner de et unikt fingeraftryk.

Citationsformater