Altered evoked responses for motor-related words in children with upper limb motor impairments

Dimitri Bredikhin; Olga Agranovich; Maxim Ulanov; Maria Koriakina; Anna N. Shestakova; Dzerassa Kadieva; Grigory Kopytin; Evgenia Ermolovich; Beatriz Bermúdez-Margaretto; Yury Shtyrov; Iiro P. Jääskeläinen; Evgeny Blagovechtchenski

doi:10.1016/j.clinph.2022.10.010

Altered evoked responses for motor-related words in children with upper limb motor impairments

Dimitri Bredikhin^*, Olga Agranovich, Maxim Ulanov, Maria Koriakina, Anna N. Shestakova, Dzerassa Kadieva, Grigory Kopytin, Evgenia Ermolovich, Beatriz Bermúdez-Margaretto, Yury Shtyrov, Iiro P. Jääskeläinen, Evgeny Blagovechtchenski

^*Corresponding author af dette arbejde

Institut for Klinisk Medicin - Center for Funktionelt Integrativ Neurovidenskab (CFIN)

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

3 Citationer (Scopus)

Abstract

Objective: Obstetric brachial plexus palsy (OBPP) and amyoplasia, the classical type of arthrogryposis multiplex congenita, manifest themselves as highly limited mobility of the upper limb. At the same time, according to the embodiment cognition theories, the motor impairments might lead to the alteration of cognitive functions in OBPP/amyoplasia patients. In the current study, we examined whether OBPP/amyoplasia children exhibit altered processing of motor-related verbs. Methods: We conducted a case-control study using clinical population and control children. Oddball series were used to elicit mismatch negativity (MMN) EEG responses. The series consisted of limb-related verbs (deviant stimuli) and matched pseudowords (standard stimuli). 27 patients and 32 control children were included in the analysis. Results: We showed that MMN waveforms differed between OBPP/amyoplasia children and their control peers in the frontal and temporal electrodes when the stimuli contained hand-related verbs. In particular, the MMN peak latency in the OBPP/amyoplasia children was significantly delayed as compared with the healthy controls. At the same time, neither series with leg-related verbs nor series of pseudowords resulted in statistically significant differences. Conclusions: Our findings suggest altered processing of hand-related verbs in OBPP/amyoplasia children with hand-related disabilities. Significance: Our results contribute to the growing evidence in support of the theory of embodied cognition, which proposes that various domains of cognition are shaped by bodily interactions with the environment.

Originalsprog	Engelsk
Tidsskrift	Clinical Neurophysiology
Vol/bind	145
Sider (fra-til)	11-21
Antal sider	11
ISSN	1388-2457
DOI	https://doi.org/10.1016/j.clinph.2022.10.010
Status	Udgivet - jan. 2023

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Bredikhin, D., Agranovich, O., Ulanov, M., Koriakina, M., Shestakova, A. N., Kadieva, D., Kopytin, G., Ermolovich, E., Bermúdez-Margaretto, B., Shtyrov, Y., Jääskeläinen, I. P., & Blagovechtchenski, E. (2023). Altered evoked responses for motor-related words in children with upper limb motor impairments. Clinical Neurophysiology, 145, 11-21. https://doi.org/10.1016/j.clinph.2022.10.010

@article{6244b1886444443c801e3cd0424704cc,

title = "Altered evoked responses for motor-related words in children with upper limb motor impairments",

abstract = "Objective: Obstetric brachial plexus palsy (OBPP) and amyoplasia, the classical type of arthrogryposis multiplex congenita, manifest themselves as highly limited mobility of the upper limb. At the same time, according to the embodiment cognition theories, the motor impairments might lead to the alteration of cognitive functions in OBPP/amyoplasia patients. In the current study, we examined whether OBPP/amyoplasia children exhibit altered processing of motor-related verbs. Methods: We conducted a case-control study using clinical population and control children. Oddball series were used to elicit mismatch negativity (MMN) EEG responses. The series consisted of limb-related verbs (deviant stimuli) and matched pseudowords (standard stimuli). 27 patients and 32 control children were included in the analysis. Results: We showed that MMN waveforms differed between OBPP/amyoplasia children and their control peers in the frontal and temporal electrodes when the stimuli contained hand-related verbs. In particular, the MMN peak latency in the OBPP/amyoplasia children was significantly delayed as compared with the healthy controls. At the same time, neither series with leg-related verbs nor series of pseudowords resulted in statistically significant differences. Conclusions: Our findings suggest altered processing of hand-related verbs in OBPP/amyoplasia children with hand-related disabilities. Significance: Our results contribute to the growing evidence in support of the theory of embodied cognition, which proposes that various domains of cognition are shaped by bodily interactions with the environment.",

keywords = "Arthrogryposis multiplex congenita, EEG, Embodied cognition, Hand movements, Mismatch negativity, Obstetric brachial plexus palsy",

author = "Dimitri Bredikhin and Olga Agranovich and Maxim Ulanov and Maria Koriakina and Shestakova, {Anna N.} and Dzerassa Kadieva and Grigory Kopytin and Evgenia Ermolovich and Beatriz Berm{\'u}dez-Margaretto and Yury Shtyrov and J{\"a}{\"a}skel{\"a}inen, {Iiro P.} and Evgeny Blagovechtchenski",

year = "2023",

month = jan,

doi = "10.1016/j.clinph.2022.10.010",

language = "English",

volume = "145",

pages = "11--21",

journal = "Clinical Neurophysiology",

issn = "1388-2457",

publisher = "Elsevier Ireland Ltd",

}

Bredikhin, D, Agranovich, O, Ulanov, M, Koriakina, M, Shestakova, AN, Kadieva, D, Kopytin, G, Ermolovich, E, Bermúdez-Margaretto, B, Shtyrov, Y, Jääskeläinen, IP & Blagovechtchenski, E 2023, 'Altered evoked responses for motor-related words in children with upper limb motor impairments', Clinical Neurophysiology, bind 145, s. 11-21. https://doi.org/10.1016/j.clinph.2022.10.010

TY - JOUR

T1 - Altered evoked responses for motor-related words in children with upper limb motor impairments

AU - Bredikhin, Dimitri

AU - Agranovich, Olga

AU - Ulanov, Maxim

AU - Koriakina, Maria

AU - Shestakova, Anna N.

AU - Kadieva, Dzerassa

AU - Kopytin, Grigory

AU - Ermolovich, Evgenia

AU - Bermúdez-Margaretto, Beatriz

AU - Shtyrov, Yury

AU - Jääskeläinen, Iiro P.

AU - Blagovechtchenski, Evgeny

PY - 2023/1

Y1 - 2023/1

N2 - Objective: Obstetric brachial plexus palsy (OBPP) and amyoplasia, the classical type of arthrogryposis multiplex congenita, manifest themselves as highly limited mobility of the upper limb. At the same time, according to the embodiment cognition theories, the motor impairments might lead to the alteration of cognitive functions in OBPP/amyoplasia patients. In the current study, we examined whether OBPP/amyoplasia children exhibit altered processing of motor-related verbs. Methods: We conducted a case-control study using clinical population and control children. Oddball series were used to elicit mismatch negativity (MMN) EEG responses. The series consisted of limb-related verbs (deviant stimuli) and matched pseudowords (standard stimuli). 27 patients and 32 control children were included in the analysis. Results: We showed that MMN waveforms differed between OBPP/amyoplasia children and their control peers in the frontal and temporal electrodes when the stimuli contained hand-related verbs. In particular, the MMN peak latency in the OBPP/amyoplasia children was significantly delayed as compared with the healthy controls. At the same time, neither series with leg-related verbs nor series of pseudowords resulted in statistically significant differences. Conclusions: Our findings suggest altered processing of hand-related verbs in OBPP/amyoplasia children with hand-related disabilities. Significance: Our results contribute to the growing evidence in support of the theory of embodied cognition, which proposes that various domains of cognition are shaped by bodily interactions with the environment.

AB - Objective: Obstetric brachial plexus palsy (OBPP) and amyoplasia, the classical type of arthrogryposis multiplex congenita, manifest themselves as highly limited mobility of the upper limb. At the same time, according to the embodiment cognition theories, the motor impairments might lead to the alteration of cognitive functions in OBPP/amyoplasia patients. In the current study, we examined whether OBPP/amyoplasia children exhibit altered processing of motor-related verbs. Methods: We conducted a case-control study using clinical population and control children. Oddball series were used to elicit mismatch negativity (MMN) EEG responses. The series consisted of limb-related verbs (deviant stimuli) and matched pseudowords (standard stimuli). 27 patients and 32 control children were included in the analysis. Results: We showed that MMN waveforms differed between OBPP/amyoplasia children and their control peers in the frontal and temporal electrodes when the stimuli contained hand-related verbs. In particular, the MMN peak latency in the OBPP/amyoplasia children was significantly delayed as compared with the healthy controls. At the same time, neither series with leg-related verbs nor series of pseudowords resulted in statistically significant differences. Conclusions: Our findings suggest altered processing of hand-related verbs in OBPP/amyoplasia children with hand-related disabilities. Significance: Our results contribute to the growing evidence in support of the theory of embodied cognition, which proposes that various domains of cognition are shaped by bodily interactions with the environment.

KW - Arthrogryposis multiplex congenita

KW - EEG

KW - Embodied cognition

KW - Hand movements

KW - Mismatch negativity

KW - Obstetric brachial plexus palsy

UR - http://www.scopus.com/inward/record.url?scp=85141950347&partnerID=8YFLogxK

U2 - 10.1016/j.clinph.2022.10.010

DO - 10.1016/j.clinph.2022.10.010

M3 - Journal article

C2 - 36395708

AN - SCOPUS:85141950347

SN - 1388-2457

VL - 145

SP - 11

EP - 21

JO - Clinical Neurophysiology

JF - Clinical Neurophysiology

ER -

Altered evoked responses for motor-related words in children with upper limb motor impairments

Abstract

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