Altered anal slow-wave pressure activity in low anterior resection syndrome: short case series in two independent specialist centres provide new mechanistic insights

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DOI

  • Paul F. Vollebregt, Queen Mary University of London
  • ,
  • Lukasz Wiklendt, Flinders University
  • ,
  • Daphne Ang, Changi General Hospital
  • ,
  • Mary L. Venn, Queen Mary University of London
  • ,
  • Mira Mekhael
  • Peter Christensen
  • Phil G. Dinning, Flinders University
  • ,
  • Charles H. Knowles, Queen Mary University of London
  • ,
  • S. Mark Scott, Queen Mary University of London

Aim: Conventional parameters (anal resting and squeeze pressures) measured with anorectal manometry (ARM) fail to identify anal sphincter dysfunction in many patients with low anterior resection syndrome (LARS). We aimed to assess whether there are differences in anal canal slow-wave pressure activity in LARS patients and healthy individuals. Method: High-resolution ARM (HR-ARM) traces of 21 consecutive male LARS patients referred to the Royal London Hospital, UK (n = 12) and Aarhus University Hospital, Denmark (n = 9) were compared with HR-ARM data from 37 healthy men. Results: Qualitatively (by visual inspection of HR-ARM recordings), the frequency of slow-wave pressure activity was strikingly different in 11/21 (52.4%) LARS patients from that observed in all the healthy individuals. Quantitative analysis showed that peaks of the mean spectrum in these 11 LARS patients occurred at approximately 6–7 cycles per minute (cpm), without activity at higher frequencies. An equivalent pattern was found in only 2/37 (5.4%) healthy individuals (P < 0.0001). Peaks of the mean spectrum in healthy individuals were concentrated at 16 cpm and 3–4 cpm. Conclusion: Over half of the male LARS patients studied had altered anal slow-wave pressure activity based on analysis of HR-ARM recordings. Further studies could investigate the relative contributions of sex, human baseline variance and neoadjuvant/surgical therapies on anal slow waves, and correlate the presence of abnormal activity with symptom severity.

OriginalsprogEngelsk
TidsskriftColorectal Disease
Vol/bind23
Nummer2
Sider (fra-til)444-450
Antal sider7
ISSN1462-8910
DOI
StatusUdgivet - feb. 2021

Bibliografisk note

Funding Information:
PFV, LW, DA, MLV, MM, PC and PGD have no conflicts of interest. CHK has received financial remuneration from Medtronic Inc. in the form of speaker fees and for expert advisory committees, and research support from Saluda Medical. SMS has received honoraria for teaching from MMS/Laborie.

Publisher Copyright:
© 2021 The Association of Coloproctology of Great Britain and Ireland

Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.

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