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Allopurinol partially prevents disuse muscle atrophy in mice and humans

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Allopurinol partially prevents disuse muscle atrophy in mice and humans. / Ferrando, Beatriz; Gomez-Cabrera, Mari Carmen; Salvador-Pascual, Andrea; Puchades, Carlos; Derbré, Frederic; Gratas-Delamarche, Arlette; Laparre, Ludovic; Olaso-Gonzalez, Gloria; Cerda, Miguel; Viosca, Enrique; Alabajos, Ana; Sebastiá, Vicente; Alberich-Bayarri, Angel; Garciá-Castro, Fabio; Vinã, Jose.

I: Scientific Reports, Bind 8, Nr. 1, 3549, 23.02.2018.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Ferrando, B, Gomez-Cabrera, MC, Salvador-Pascual, A, Puchades, C, Derbré, F, Gratas-Delamarche, A, Laparre, L, Olaso-Gonzalez, G, Cerda, M, Viosca, E, Alabajos, A, Sebastiá, V, Alberich-Bayarri, A, Garciá-Castro, F & Vinã, J 2018, 'Allopurinol partially prevents disuse muscle atrophy in mice and humans', Scientific Reports, bind 8, nr. 1, 3549. https://doi.org/10.1038/s41598-018-21552-1

APA

Ferrando, B., Gomez-Cabrera, M. C., Salvador-Pascual, A., Puchades, C., Derbré, F., Gratas-Delamarche, A., ... Vinã, J. (2018). Allopurinol partially prevents disuse muscle atrophy in mice and humans. Scientific Reports, 8(1), [3549]. https://doi.org/10.1038/s41598-018-21552-1

CBE

Ferrando B, Gomez-Cabrera MC, Salvador-Pascual A, Puchades C, Derbré F, Gratas-Delamarche A, Laparre L, Olaso-Gonzalez G, Cerda M, Viosca E, Alabajos A, Sebastiá V, Alberich-Bayarri A, Garciá-Castro F, Vinã J. 2018. Allopurinol partially prevents disuse muscle atrophy in mice and humans. Scientific Reports. 8(1). https://doi.org/10.1038/s41598-018-21552-1

MLA

Vancouver

Ferrando B, Gomez-Cabrera MC, Salvador-Pascual A, Puchades C, Derbré F, Gratas-Delamarche A o.a. Allopurinol partially prevents disuse muscle atrophy in mice and humans. Scientific Reports. 2018 feb 23;8(1). 3549. https://doi.org/10.1038/s41598-018-21552-1

Author

Ferrando, Beatriz ; Gomez-Cabrera, Mari Carmen ; Salvador-Pascual, Andrea ; Puchades, Carlos ; Derbré, Frederic ; Gratas-Delamarche, Arlette ; Laparre, Ludovic ; Olaso-Gonzalez, Gloria ; Cerda, Miguel ; Viosca, Enrique ; Alabajos, Ana ; Sebastiá, Vicente ; Alberich-Bayarri, Angel ; Garciá-Castro, Fabio ; Vinã, Jose. / Allopurinol partially prevents disuse muscle atrophy in mice and humans. I: Scientific Reports. 2018 ; Bind 8, Nr. 1.

Bibtex

@article{f4bf1833547645fdb88e6f6efd82e5e7,
title = "Allopurinol partially prevents disuse muscle atrophy in mice and humans",
abstract = "Disuse muscle wasting will likely affect everyone in his or her lifetime in response to pathologies such as joint immobilization, inactivity or bed rest. There are no good therapies to treat it. We previously found that allopurinol, a drug widely used to treat gout, protects muscle damage after exhaustive exercise and results in functional gains in old individuals. Thus, we decided to test its effect in the prevention of soleus muscle atrophy after two weeks of hindlimb unloading in mice, and lower leg immobilization following ankle sprain in humans (EudraCT: 2011-003541-17). Our results show that allopurinol partially protects against muscle atrophy in both mice and humans. The protective effect of allopurinol is similar to that of resistance exercise which is the best-known way to prevent muscle mass loss in disuse human models. We report that allopurinol protects against the loss of muscle mass by inhibiting the expression of ubiquitin ligases. Our results suggest that the ubiquitin-proteasome pathway is an appropriate therapeutic target to inhibit muscle wasting and emphasizes the role of allopurinol as a non-hormonal intervention to treat disuse muscle atrophy.",
author = "Beatriz Ferrando and Gomez-Cabrera, {Mari Carmen} and Andrea Salvador-Pascual and Carlos Puchades and Frederic Derbr{\'e} and Arlette Gratas-Delamarche and Ludovic Laparre and Gloria Olaso-Gonzalez and Miguel Cerda and Enrique Viosca and Ana Alabajos and Vicente Sebasti{\'a} and Angel Alberich-Bayarri and Fabio Garci{\'a}-Castro and Jose Vin{\~a}",
year = "2018",
month = "2",
day = "23",
doi = "10.1038/s41598-018-21552-1",
language = "English",
volume = "8",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",

}

RIS

TY - JOUR

T1 - Allopurinol partially prevents disuse muscle atrophy in mice and humans

AU - Ferrando, Beatriz

AU - Gomez-Cabrera, Mari Carmen

AU - Salvador-Pascual, Andrea

AU - Puchades, Carlos

AU - Derbré, Frederic

AU - Gratas-Delamarche, Arlette

AU - Laparre, Ludovic

AU - Olaso-Gonzalez, Gloria

AU - Cerda, Miguel

AU - Viosca, Enrique

AU - Alabajos, Ana

AU - Sebastiá, Vicente

AU - Alberich-Bayarri, Angel

AU - Garciá-Castro, Fabio

AU - Vinã, Jose

PY - 2018/2/23

Y1 - 2018/2/23

N2 - Disuse muscle wasting will likely affect everyone in his or her lifetime in response to pathologies such as joint immobilization, inactivity or bed rest. There are no good therapies to treat it. We previously found that allopurinol, a drug widely used to treat gout, protects muscle damage after exhaustive exercise and results in functional gains in old individuals. Thus, we decided to test its effect in the prevention of soleus muscle atrophy after two weeks of hindlimb unloading in mice, and lower leg immobilization following ankle sprain in humans (EudraCT: 2011-003541-17). Our results show that allopurinol partially protects against muscle atrophy in both mice and humans. The protective effect of allopurinol is similar to that of resistance exercise which is the best-known way to prevent muscle mass loss in disuse human models. We report that allopurinol protects against the loss of muscle mass by inhibiting the expression of ubiquitin ligases. Our results suggest that the ubiquitin-proteasome pathway is an appropriate therapeutic target to inhibit muscle wasting and emphasizes the role of allopurinol as a non-hormonal intervention to treat disuse muscle atrophy.

AB - Disuse muscle wasting will likely affect everyone in his or her lifetime in response to pathologies such as joint immobilization, inactivity or bed rest. There are no good therapies to treat it. We previously found that allopurinol, a drug widely used to treat gout, protects muscle damage after exhaustive exercise and results in functional gains in old individuals. Thus, we decided to test its effect in the prevention of soleus muscle atrophy after two weeks of hindlimb unloading in mice, and lower leg immobilization following ankle sprain in humans (EudraCT: 2011-003541-17). Our results show that allopurinol partially protects against muscle atrophy in both mice and humans. The protective effect of allopurinol is similar to that of resistance exercise which is the best-known way to prevent muscle mass loss in disuse human models. We report that allopurinol protects against the loss of muscle mass by inhibiting the expression of ubiquitin ligases. Our results suggest that the ubiquitin-proteasome pathway is an appropriate therapeutic target to inhibit muscle wasting and emphasizes the role of allopurinol as a non-hormonal intervention to treat disuse muscle atrophy.

UR - http://www.scopus.com/inward/record.url?scp=85042534632&partnerID=8YFLogxK

U2 - 10.1038/s41598-018-21552-1

DO - 10.1038/s41598-018-21552-1

M3 - Journal article

C2 - 29476130

AN - SCOPUS:85042534632

VL - 8

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

IS - 1

M1 - 3549

ER -