Akt Regulates a Rab11-Effector Switch Required for Ciliogenesis

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Standard

Akt Regulates a Rab11-Effector Switch Required for Ciliogenesis. / Walia, Vijay; Cuenca, Adrian; Vetter, Melanie; Insinna, Christine; Perera, Sumeth; Lu, Quanlong; Ritt, Daniel A.; Semler, Elizabeth; Specht, Suzanne; Stauffer, Jimmy; Morrison, Deborah K.; Lorentzen, Esben; Westlake, Christopher J.

I: Developmental Cell, Bind 50, Nr. 2, 2019, s. 229-246.e7.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Walia, V, Cuenca, A, Vetter, M, Insinna, C, Perera, S, Lu, Q, Ritt, DA, Semler, E, Specht, S, Stauffer, J, Morrison, DK, Lorentzen, E & Westlake, CJ 2019, 'Akt Regulates a Rab11-Effector Switch Required for Ciliogenesis', Developmental Cell, bind 50, nr. 2, s. 229-246.e7. https://doi.org/10.1016/j.devcel.2019.05.022

APA

Walia, V., Cuenca, A., Vetter, M., Insinna, C., Perera, S., Lu, Q., Ritt, D. A., Semler, E., Specht, S., Stauffer, J., Morrison, D. K., Lorentzen, E., & Westlake, C. J. (2019). Akt Regulates a Rab11-Effector Switch Required for Ciliogenesis. Developmental Cell, 50(2), 229-246.e7. https://doi.org/10.1016/j.devcel.2019.05.022

CBE

Walia V, Cuenca A, Vetter M, Insinna C, Perera S, Lu Q, Ritt DA, Semler E, Specht S, Stauffer J, Morrison DK, Lorentzen E, Westlake CJ. 2019. Akt Regulates a Rab11-Effector Switch Required for Ciliogenesis. Developmental Cell. 50(2):229-246.e7. https://doi.org/10.1016/j.devcel.2019.05.022

MLA

Vancouver

Walia V, Cuenca A, Vetter M, Insinna C, Perera S, Lu Q o.a. Akt Regulates a Rab11-Effector Switch Required for Ciliogenesis. Developmental Cell. 2019;50(2):229-246.e7. https://doi.org/10.1016/j.devcel.2019.05.022

Author

Walia, Vijay ; Cuenca, Adrian ; Vetter, Melanie ; Insinna, Christine ; Perera, Sumeth ; Lu, Quanlong ; Ritt, Daniel A. ; Semler, Elizabeth ; Specht, Suzanne ; Stauffer, Jimmy ; Morrison, Deborah K. ; Lorentzen, Esben ; Westlake, Christopher J. / Akt Regulates a Rab11-Effector Switch Required for Ciliogenesis. I: Developmental Cell. 2019 ; Bind 50, Nr. 2. s. 229-246.e7.

Bibtex

@article{bb09358282274f6db11b1e37185c2f9e,
title = "Akt Regulates a Rab11-Effector Switch Required for Ciliogenesis",
abstract = "Cilia assembly is inhibited by activation of the PI3K/Akt pathway by the serum factor lysophosphatidic acid, independent of cell cycle alterations. Walia et al. show that activated Akt phosphorylates WDR44, stabilizing its effector-based binding to Rab11 and preventing Rabin8 preciliary trafficking and ciliogenesis initiation.",
keywords = "Akt, ciliogenesis, FIP3, LPA, lysophosphatidic acid, MC, mother centriole, phosphorylation, preciliary trafficking, Rab11 effector switch, Rabin8, WDR44",
author = "Vijay Walia and Adrian Cuenca and Melanie Vetter and Christine Insinna and Sumeth Perera and Quanlong Lu and Ritt, {Daniel A.} and Elizabeth Semler and Suzanne Specht and Jimmy Stauffer and Morrison, {Deborah K.} and Esben Lorentzen and Westlake, {Christopher J.}",
year = "2019",
doi = "10.1016/j.devcel.2019.05.022",
language = "English",
volume = "50",
pages = "229--246.e7",
journal = "Developmental Cell",
issn = "1534-5807",
publisher = "Cell Press",
number = "2",

}

RIS

TY - JOUR

T1 - Akt Regulates a Rab11-Effector Switch Required for Ciliogenesis

AU - Walia, Vijay

AU - Cuenca, Adrian

AU - Vetter, Melanie

AU - Insinna, Christine

AU - Perera, Sumeth

AU - Lu, Quanlong

AU - Ritt, Daniel A.

AU - Semler, Elizabeth

AU - Specht, Suzanne

AU - Stauffer, Jimmy

AU - Morrison, Deborah K.

AU - Lorentzen, Esben

AU - Westlake, Christopher J.

PY - 2019

Y1 - 2019

N2 - Cilia assembly is inhibited by activation of the PI3K/Akt pathway by the serum factor lysophosphatidic acid, independent of cell cycle alterations. Walia et al. show that activated Akt phosphorylates WDR44, stabilizing its effector-based binding to Rab11 and preventing Rabin8 preciliary trafficking and ciliogenesis initiation.

AB - Cilia assembly is inhibited by activation of the PI3K/Akt pathway by the serum factor lysophosphatidic acid, independent of cell cycle alterations. Walia et al. show that activated Akt phosphorylates WDR44, stabilizing its effector-based binding to Rab11 and preventing Rabin8 preciliary trafficking and ciliogenesis initiation.

KW - Akt

KW - ciliogenesis

KW - FIP3

KW - LPA

KW - lysophosphatidic acid

KW - MC

KW - mother centriole

KW - phosphorylation

KW - preciliary trafficking

KW - Rab11 effector switch

KW - Rabin8

KW - WDR44

UR - http://www.scopus.com/inward/record.url?scp=85067306252&partnerID=8YFLogxK

U2 - 10.1016/j.devcel.2019.05.022

DO - 10.1016/j.devcel.2019.05.022

M3 - Journal article

C2 - 31204173

AN - SCOPUS:85067306252

VL - 50

SP - 229-246.e7

JO - Developmental Cell

JF - Developmental Cell

SN - 1534-5807

IS - 2

ER -