Akt Regulates a Rab11-Effector Switch Required for Ciliogenesis

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  • Vijay Walia, National Cancer Institute at Frederick
  • ,
  • Adrian Cuenca, National Cancer Institute at Frederick
  • ,
  • Melanie Vetter
  • ,
  • Christine Insinna, National Cancer Institute at Frederick
  • ,
  • Sumeth Perera, National Cancer Institute at Frederick
  • ,
  • Quanlong Lu, National Cancer Institute at Frederick
  • ,
  • Daniel A. Ritt, National Cancer Institute at Frederick
  • ,
  • Elizabeth Semler, National Cancer Institute at Frederick
  • ,
  • Suzanne Specht, National Cancer Institute at Frederick
  • ,
  • Jimmy Stauffer, National Cancer Institute at Frederick
  • ,
  • Deborah K. Morrison, National Cancer Institute at Frederick
  • ,
  • Esben Lorentzen
  • Christopher J. Westlake, National Cancer Institute at Frederick

Cilia assembly is inhibited by activation of the PI3K/Akt pathway by the serum factor lysophosphatidic acid, independent of cell cycle alterations. Walia et al. show that activated Akt phosphorylates WDR44, stabilizing its effector-based binding to Rab11 and preventing Rabin8 preciliary trafficking and ciliogenesis initiation.

OriginalsprogEngelsk
TidsskriftDevelopmental Cell
Vol/bind50
Nummer2
Sider (fra-til)229-246.e7
Antal sider18
ISSN1534-5807
DOI
StatusUdgivet - 2019

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