Aging is not a disease: implications for intervention

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Aging is not a disease: implications for intervention. / Rattan, Suresh.

I: Aging and Disease, Bind 5, Nr. 3, 2014, s. 196-202.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisReviewForskningpeer review

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Rattan, Suresh. / Aging is not a disease: implications for intervention. I: Aging and Disease. 2014 ; Bind 5, Nr. 3. s. 196-202.

Bibtex

@article{039d1bf09f4a419facce82648afcc0d2,
title = "Aging is not a disease: implications for intervention",
abstract = "Aging of biological systems occurs in spite of numerous complex pathways of maintenance, repair and defense. There are no gerontogenes which have the specific evolutionary function to cause aging. Although aging is the common cause of all age-related diseases, aging in itself cannot be considered a disease. This understanding of aging as a process should transform our approach towards interventions from developing illusory anti-aging treatments to developing realistic and practical methods for maintaining health throughout the lifespan. The concept of homeodynamic space can be a useful one in order to identify a set of measurable, evidence-based and demonstratable parameters of health, robustness and resilience. Age-induced health problems, for which there are no other clear-cut causative agents, may be better tackled by focusing on health mechanisms and their maintenance, rather than only disease management and treatment. Continuing the disease-oriented research and treatment approaches, as opposed to health-oriented and preventive strategies, are economically, socially and psychologically unsustainable. ",
keywords = "longevity, stress, homeostasis, homeodynamics, hormetics, hormesis, hormetin",
author = "Suresh Rattan",
year = "2014",
doi = "10.14336/AD.2014.0500196",
language = "English",
volume = "5",
pages = "196--202",
journal = "Aging and Disease",
issn = "2152-5250",
publisher = "Buck Institute for Age Research",
number = "3",

}

RIS

TY - JOUR

T1 - Aging is not a disease: implications for intervention

AU - Rattan, Suresh

PY - 2014

Y1 - 2014

N2 - Aging of biological systems occurs in spite of numerous complex pathways of maintenance, repair and defense. There are no gerontogenes which have the specific evolutionary function to cause aging. Although aging is the common cause of all age-related diseases, aging in itself cannot be considered a disease. This understanding of aging as a process should transform our approach towards interventions from developing illusory anti-aging treatments to developing realistic and practical methods for maintaining health throughout the lifespan. The concept of homeodynamic space can be a useful one in order to identify a set of measurable, evidence-based and demonstratable parameters of health, robustness and resilience. Age-induced health problems, for which there are no other clear-cut causative agents, may be better tackled by focusing on health mechanisms and their maintenance, rather than only disease management and treatment. Continuing the disease-oriented research and treatment approaches, as opposed to health-oriented and preventive strategies, are economically, socially and psychologically unsustainable.

AB - Aging of biological systems occurs in spite of numerous complex pathways of maintenance, repair and defense. There are no gerontogenes which have the specific evolutionary function to cause aging. Although aging is the common cause of all age-related diseases, aging in itself cannot be considered a disease. This understanding of aging as a process should transform our approach towards interventions from developing illusory anti-aging treatments to developing realistic and practical methods for maintaining health throughout the lifespan. The concept of homeodynamic space can be a useful one in order to identify a set of measurable, evidence-based and demonstratable parameters of health, robustness and resilience. Age-induced health problems, for which there are no other clear-cut causative agents, may be better tackled by focusing on health mechanisms and their maintenance, rather than only disease management and treatment. Continuing the disease-oriented research and treatment approaches, as opposed to health-oriented and preventive strategies, are economically, socially and psychologically unsustainable.

KW - longevity

KW - stress

KW - homeostasis

KW - homeodynamics

KW - hormetics

KW - hormesis

KW - hormetin

U2 - 10.14336/AD.2014.0500196

DO - 10.14336/AD.2014.0500196

M3 - Review

C2 - 24900942

VL - 5

SP - 196

EP - 202

JO - Aging and Disease

JF - Aging and Disease

SN - 2152-5250

IS - 3

ER -