Acute metabolic effects of melatonin - a randomized crossover study in healthy young men

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  • Ulla Kampmann
  • Esben S Lauritzen
  • Niels Grarup, Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • ,
  • Niels Jessen
  • Torben Hansen, Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • ,
  • Niels Møller
  • Julie Støy

Melatonin regulates circadian rhythm, but may also have effects on glucose-homeostasis. A common G-allele in the MTNR1B-locus has been associated with an increased risk of type 2 diabetes (T2DM). We aimed to examine acute effects of high doses of melatonin on glucose-metabolism with attention to MTNR1B genotype. Twenty men were examined in a double-blinded, randomized crossover study on two non-consecutive days with four doses of 10 mg oral melatonin or placebo. Insulin sensitivity and insulin secretion were assessed by an intravenous-glucose-tolerance-test (IVGTT) and a hyperinsulinemic euglycemic clamp (HEC). Blood samples were drawn to determine the metabolic profile and MTNR1B-rs10830963 genotype. Indirect calorimetry and blood pressure measurements were also performed. Insulin sensitivity index, was significantly reduced on the melatonin day (P=0.028) in the whole group and in homozygous carriers of the rs10830963 C-allele (p=0.041). Glucose during the IVGTT was unaffected, but there was a tendency towards lower insulin and C-peptide levels in the first minutes after glucose administration in G-allele carriers. Systolic blood pressure decreased and lipid-oxidation increased significantly on the melatonin day in rs10830963 G-allele carriers. Overall, our study reports that acute administration of melatonin in supra-physiological doses may have a negative impact on insulin sensitivity.

OriginalsprogEngelsk
Artikelnummere12706
TidsskriftJournal of Pineal Research
Vol/bind70
Nummer2
Antal sider13
ISSN0742-3098
DOI
StatusUdgivet - mar. 2021

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