TY - JOUR
T1 - Acute effects of the coffee diterpene cafestol on glucose metabolism in non-diabetic subjects with abdominal obesity
AU - Mellbye, Fredrik Drews
AU - Hermansen, Kjeld
AU - Jeppesen, Per Bendix
AU - Gregersen, Søren
PY - 2023/6
Y1 - 2023/6
N2 - Objectives: Coffee consumption is associated with a reduced risk of Type-2 Diabetes. A bioactive compound in coffee, cafestol, has shown potential preventive effects for Type-2 Diabetes in cell and animal studies, but its potential benefits in humans have not been examined. Methods: In this randomized, double-blinded crossover intervention study, 15 healthy participants with increased waist circumference and thus elevated risk of developing Type-2 Diabetes underwent three oral glucose tolerance tests one week apart, with placebo, 7 mg-or 14 mg cafestol capsules ingested with the glucose load. Results: There were no substantial differences in area under the curve (AUC) for glucose, insulin, glucagon-like peptide 1 (GLP-1) or gastric inhibitory peptide (GIP) on placebo or cafestol intervention study days. Among participants with impaired glucose tolerance and/or elevated fasting glucose (n=8, 53%), ingestion of 14 mg of cafestol resulted in an 11% larger AUC for GIP (p=0.046) and a 5% smaller AUC for glucose (p=0.14), compared to placebo. Conclusions: Our results suggest that cafestol may contribute to coffee's inverse association with risk of Type-2 Diabetes, particularly in subjects with impaired glucose tolerance, possibly through increased GIP secretion. Further studies are needed to confirm these novel findings in participants with impaired glucose metabolism, both after acute and longer-term cafestol intervention.
AB - Objectives: Coffee consumption is associated with a reduced risk of Type-2 Diabetes. A bioactive compound in coffee, cafestol, has shown potential preventive effects for Type-2 Diabetes in cell and animal studies, but its potential benefits in humans have not been examined. Methods: In this randomized, double-blinded crossover intervention study, 15 healthy participants with increased waist circumference and thus elevated risk of developing Type-2 Diabetes underwent three oral glucose tolerance tests one week apart, with placebo, 7 mg-or 14 mg cafestol capsules ingested with the glucose load. Results: There were no substantial differences in area under the curve (AUC) for glucose, insulin, glucagon-like peptide 1 (GLP-1) or gastric inhibitory peptide (GIP) on placebo or cafestol intervention study days. Among participants with impaired glucose tolerance and/or elevated fasting glucose (n=8, 53%), ingestion of 14 mg of cafestol resulted in an 11% larger AUC for GIP (p=0.046) and a 5% smaller AUC for glucose (p=0.14), compared to placebo. Conclusions: Our results suggest that cafestol may contribute to coffee's inverse association with risk of Type-2 Diabetes, particularly in subjects with impaired glucose tolerance, possibly through increased GIP secretion. Further studies are needed to confirm these novel findings in participants with impaired glucose metabolism, both after acute and longer-term cafestol intervention.
KW - cafestol
KW - coffee
KW - cross-over studies
KW - humans
KW - insulin resistance
KW - obesity
KW - randomized controlled trial
KW - type 2 diabetes mellitus
U2 - 10.1900/RDS.2023.19.34
DO - 10.1900/RDS.2023.19.34
M3 - Journal article
SN - 1613-6071
VL - 19
SP - 34
EP - 42
JO - The Review of Diabetic Studies
JF - The Review of Diabetic Studies
IS - 2
ER -