Acute and sustained effects of a periodized carbohydrate intake using the sleep-low model in endurance-trained males.

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Acute and sustained effects of a periodized carbohydrate intake using the sleep-low model in endurance-trained males. / Riis, Simon; Møller, Andreas Buch; Dollerup, Ole Lindgård; Høffner, Line; Jessen, Niels; Madsen, Klavs.

I: Scandinavian Journal of Medicine & Science in Sports, Bind 29, Nr. 12, 12.2019, s. 1866-1880.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

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Riis, Simon ; Møller, Andreas Buch ; Dollerup, Ole Lindgård ; Høffner, Line ; Jessen, Niels ; Madsen, Klavs. / Acute and sustained effects of a periodized carbohydrate intake using the sleep-low model in endurance-trained males. I: Scandinavian Journal of Medicine & Science in Sports. 2019 ; Bind 29, Nr. 12. s. 1866-1880.

Bibtex

@article{291bdb21b9294eabb3a9efd696b28f2f,
title = "Acute and sustained effects of a periodized carbohydrate intake using the sleep-low model in endurance-trained males.",
abstract = "Repeated periodization of carbohydrate (CHO) intake using a diet-exercise strategy called the sleep-low model can potentially induce mitochondrial biogenesis and improve endurance performance in endurance-trained individuals. However, more studies are needed to confirm the performance-related effects and to investigate the sustained effects on maximal fat oxidation (MFO) rate and proteins involved in intramuscular lipid metabolism. Thirteen endurance-trained males (age 23-44 years; VO 2-max, 63.9 ± 4.6 mL·kg −1·min −1) were randomized into two groups: sleep-low (LOW-CHO) or high CHO availability (HIGH-CHO) in three weekly training blocks over 4 weeks. The acute metabolic response was investigated during 60 minutes of exercise within the last 3 weeks of the intervention. Pre- and post-intervention, 30-minute time-trial performance was investigated after a 90-minute pre-load, which as a novel approach included nine intense intervals (and estimation of MFO). Additionally, muscle biopsies (v. lateralis) were obtained to investigate expression of proteins involved in intramuscular lipid metabolism using Western blotting. During acute exercise, average fat oxidation rate was ~36{\%} higher in LOW-CHO compared to HIGH-CHO (P =.03). This did not translate into sustained effects on MFO. Time-trial performance increased equally in both groups (overall time effect: P =.005). We observed no effect on intramuscular proteins involved in lipolysis (ATGL, G0S2, CGI-58, HSL) or fatty acid transport and β-oxidation (CD-36 and HAD, respectively). In conclusion, the sleep-low model did not induce sustained effects on MFO, endurance performance, or proteins involved in intramuscular lipid metabolism when compared to HIGH-CHO. Our study therefore questions the transferability of acute effects of the sleep-low model to superior sustained adaptations.",
keywords = "diet-exercise strategy, endurance performance, indirect calorimetry, intramuscular lipolysis, maximal fat oxidation rate, protein expression",
author = "Simon Riis and M{\o}ller, {Andreas Buch} and Dollerup, {Ole Lindg{\aa}rd} and Line H{\o}ffner and Niels Jessen and Klavs Madsen",
year = "2019",
month = "12",
doi = "10.1111/sms.13541",
language = "English",
volume = "29",
pages = "1866--1880",
journal = "Scandinavian Journal of Medicine & Science in Sports",
issn = "0905-7188",
publisher = "Wiley-Blackwell Publishing Ltd",
number = "12",

}

RIS

TY - JOUR

T1 - Acute and sustained effects of a periodized carbohydrate intake using the sleep-low model in endurance-trained males.

AU - Riis, Simon

AU - Møller, Andreas Buch

AU - Dollerup, Ole Lindgård

AU - Høffner, Line

AU - Jessen, Niels

AU - Madsen, Klavs

PY - 2019/12

Y1 - 2019/12

N2 - Repeated periodization of carbohydrate (CHO) intake using a diet-exercise strategy called the sleep-low model can potentially induce mitochondrial biogenesis and improve endurance performance in endurance-trained individuals. However, more studies are needed to confirm the performance-related effects and to investigate the sustained effects on maximal fat oxidation (MFO) rate and proteins involved in intramuscular lipid metabolism. Thirteen endurance-trained males (age 23-44 years; VO 2-max, 63.9 ± 4.6 mL·kg −1·min −1) were randomized into two groups: sleep-low (LOW-CHO) or high CHO availability (HIGH-CHO) in three weekly training blocks over 4 weeks. The acute metabolic response was investigated during 60 minutes of exercise within the last 3 weeks of the intervention. Pre- and post-intervention, 30-minute time-trial performance was investigated after a 90-minute pre-load, which as a novel approach included nine intense intervals (and estimation of MFO). Additionally, muscle biopsies (v. lateralis) were obtained to investigate expression of proteins involved in intramuscular lipid metabolism using Western blotting. During acute exercise, average fat oxidation rate was ~36% higher in LOW-CHO compared to HIGH-CHO (P =.03). This did not translate into sustained effects on MFO. Time-trial performance increased equally in both groups (overall time effect: P =.005). We observed no effect on intramuscular proteins involved in lipolysis (ATGL, G0S2, CGI-58, HSL) or fatty acid transport and β-oxidation (CD-36 and HAD, respectively). In conclusion, the sleep-low model did not induce sustained effects on MFO, endurance performance, or proteins involved in intramuscular lipid metabolism when compared to HIGH-CHO. Our study therefore questions the transferability of acute effects of the sleep-low model to superior sustained adaptations.

AB - Repeated periodization of carbohydrate (CHO) intake using a diet-exercise strategy called the sleep-low model can potentially induce mitochondrial biogenesis and improve endurance performance in endurance-trained individuals. However, more studies are needed to confirm the performance-related effects and to investigate the sustained effects on maximal fat oxidation (MFO) rate and proteins involved in intramuscular lipid metabolism. Thirteen endurance-trained males (age 23-44 years; VO 2-max, 63.9 ± 4.6 mL·kg −1·min −1) were randomized into two groups: sleep-low (LOW-CHO) or high CHO availability (HIGH-CHO) in three weekly training blocks over 4 weeks. The acute metabolic response was investigated during 60 minutes of exercise within the last 3 weeks of the intervention. Pre- and post-intervention, 30-minute time-trial performance was investigated after a 90-minute pre-load, which as a novel approach included nine intense intervals (and estimation of MFO). Additionally, muscle biopsies (v. lateralis) were obtained to investigate expression of proteins involved in intramuscular lipid metabolism using Western blotting. During acute exercise, average fat oxidation rate was ~36% higher in LOW-CHO compared to HIGH-CHO (P =.03). This did not translate into sustained effects on MFO. Time-trial performance increased equally in both groups (overall time effect: P =.005). We observed no effect on intramuscular proteins involved in lipolysis (ATGL, G0S2, CGI-58, HSL) or fatty acid transport and β-oxidation (CD-36 and HAD, respectively). In conclusion, the sleep-low model did not induce sustained effects on MFO, endurance performance, or proteins involved in intramuscular lipid metabolism when compared to HIGH-CHO. Our study therefore questions the transferability of acute effects of the sleep-low model to superior sustained adaptations.

KW - diet-exercise strategy

KW - endurance performance

KW - indirect calorimetry

KW - intramuscular lipolysis

KW - maximal fat oxidation rate

KW - protein expression

UR - http://www.scopus.com/inward/record.url?scp=85073972106&partnerID=8YFLogxK

U2 - 10.1111/sms.13541

DO - 10.1111/sms.13541

M3 - Journal article

C2 - 31430404

VL - 29

SP - 1866

EP - 1880

JO - Scandinavian Journal of Medicine & Science in Sports

JF - Scandinavian Journal of Medicine & Science in Sports

SN - 0905-7188

IS - 12

ER -