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Acute and short term chronic testosterone fluctuations effects on glucose homeostasis, insulin sensitivity and adiponectin. A randomized, double-blind, placebo-controlled, cross-over study

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Context: Low levels of adiponectin and testosterone in men have been shown to predict development of the metabolic syndrome, but the effects of testosterone on glucose metabolism are incompletely understood and may be influenced either directly or indirectly through changes in body composition or in levels of adiponectin. Objective: To test whether testosterone exerts its effects on glucose metabolism directly or indirectly. Design, setting, and participants: In a randomized, double-blind, placebo-controlled, cross-over study, 12 healthy young males were studied on 4 separate occasions. They received GnRH agonist treatment 1 month prior to 3 of 4 trial days to induce castrate levels of testosterone hypogonadism. On trial days, testosterone gel was applied to the body containing either high or low physiological testosterone dose or placebo. On a fourth trial day, participants constituted their own eugonadal controls. Intervention: Each study comprised a 5-h basal period and a 3-h hyperinsulinemic euglycemic clamp. Main Outcome Measures: Effect of acute testosterone on peripheral glucose disposal, total adiponectin and subforms and other indices of glucose metabolism. Results: Short term hypogonadism was associated with increased HMW adiponectin levels (P<0.03) and increased oxidative glucose disposal (P=0.03), but not total glucose disposal (P=0.07). Acute T treatment was an independent suppressor of HMW adiponectin levels (P=0.04), but did not affect total glucose disposal (P=0.17). Conclusions: These data show that testosterone can act through putative fast nongenomic pathways to affect adiponectin levels in humans. The early hypogonadal state is characterized by a marked shift in fuel oxidation from lipids towards glucose, which partly may rely on buffering capabilities of adiponectin.

TidsskriftJournal of Clinical Endocrinology and Metabolism
Sider (fra-til)jc20132807
StatusUdgivet - 28 feb. 2014

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