Active lifestyle enhances protein expression profile in subjects with Lewy body pathology

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  • Caroline Cristiano Real, Laboratoy of Nuclear Medicine
  • ,
  • Cláudia Kimie Suemoto, Department of Neurobiology, Care Sciences and Society, Aging Research Center, Karolinska Institutet; Stockholm Gerontology Research Center; and Division of Clinical Geriatrics, Karolinska University Hospital, Stockholm, Sweden.
  • ,
  • Karina Henrique Binda
  • Lea Tenenholz Grinberg, University of California at San Francisco
  • ,
  • Carlos Augusto Pasqualucci, Department of Pathology
  • ,
  • Wilson Jacob, Department of Neurobiology, Care Sciences and Society, Aging Research Center, Karolinska Institutet; Stockholm Gerontology Research Center; and Division of Clinical Geriatrics, Karolinska University Hospital, Stockholm, Sweden.
  • ,
  • Renata Eloah de Lucena Ferretti-Rebustini, Medical-Surgical Nursing Department
  • ,
  • Ricardo Nitrini, Department of Neurology, Frankfurt am Main, Germany; Department of Neurology, Heidelberg University Hospital, Germany.
  • ,
  • Renata Elaine Paraizo Leite, Department of Neurobiology, Care Sciences and Society, Aging Research Center, Karolinska Institutet; Stockholm Gerontology Research Center; and Division of Clinical Geriatrics, Karolinska University Hospital, Stockholm, Sweden.
  • ,
  • Luiz Roberto de Britto, Laboratory of Cellular Neurobiology

Clinical trials of the effects of physical activity have reported improvements in symptoms and quality of life in patients with Parkinson's disease (PD). Additionally, morphological brain changes after exercising were reported in PD animal models. However, these lifestyle-related changes were not evaluated in postmortem brain tissue.

Objective: We aimed to evaluate, by immunohistochemistry, astrocytes, tyrosine hydroxylase (TH) and structural proteins expression (neurofilaments and microtubules - MAP2) changes in postmortem brain samples of individuals with Lewy body pathology.

Methods: Braak PD stage≥III samples, classified by neuropathology analysis, from The Biobank for Aging Studies were classified into active (n=12) and non-active (n=12) groups, according to physical activity lifestyle, and paired by age, sex and Braak staging. Substantia nigra and basal ganglia were evaluated.

Results: Groups were not different in terms of age or gender and had similar PD neuropathological burden (p=1.00). We observed higher TH expression in the active group in the substantia nigra and the basal ganglia (p=0.04). Astrocytes was greater in the non-active subjects in the midbrain (p=0.03) and basal ganglia (p=0.0004). MAP2 levels were higher for non-active participants in the basal ganglia (p=0.003) and similar between groups in the substantia nigra (p=0.46). Neurofilament levels for non-active participants were higher in the substantia nigra (p=0.006) but not in the basal ganglia (p=0.24).

Conclusion: Active lifestyle seems to promote positive effects on brain by maintaining dopamine synthesis and structural protein expression in the nigrostriatal system and decrease astrogliosis in subjects with the same PD neuropathology burden.

OriginalsprogEngelsk
TidsskriftDementia e Neuropsychologia
Vol/bind15
Nummer1
Sider (fra-til)41-50
Antal sider10
ISSN1980-5764
DOI
StatusUdgivet - 29 apr. 2021
Eksternt udgivetJa

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