Activation of proto-oncogenes by disruption of chromosome neighborhoods

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Activation of proto-oncogenes by disruption of chromosome neighborhoods. / Hnisz, Denes; Weintraub, Abraham S; Day, Daniel S; Valton, Anne-Laure; Bak, Rasmus O; Li, Charles H; Goldmann, Johanna; Lajoie, Bryan R; Fan, Zi Peng; Sigova, Alla A; Reddy, Jessica; Borges-Rivera, Diego; Lee, Tong Ihn; Jaenisch, Rudolf; Porteus, Matthew H; Dekker, Job; Young, Richard A.

I: Science, Bind 351, Nr. 6280, 25.03.2016, s. 1454-1458.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Hnisz, D, Weintraub, AS, Day, DS, Valton, A-L, Bak, RO, Li, CH, Goldmann, J, Lajoie, BR, Fan, ZP, Sigova, AA, Reddy, J, Borges-Rivera, D, Lee, TI, Jaenisch, R, Porteus, MH, Dekker, J & Young, RA 2016, 'Activation of proto-oncogenes by disruption of chromosome neighborhoods', Science, bind 351, nr. 6280, s. 1454-1458. https://doi.org/10.1126/science.aad9024

APA

Hnisz, D., Weintraub, A. S., Day, D. S., Valton, A-L., Bak, R. O., Li, C. H., ... Young, R. A. (2016). Activation of proto-oncogenes by disruption of chromosome neighborhoods. Science, 351(6280), 1454-1458. https://doi.org/10.1126/science.aad9024

CBE

Hnisz D, Weintraub AS, Day DS, Valton A-L, Bak RO, Li CH, Goldmann J, Lajoie BR, Fan ZP, Sigova AA, Reddy J, Borges-Rivera D, Lee TI, Jaenisch R, Porteus MH, Dekker J, Young RA. 2016. Activation of proto-oncogenes by disruption of chromosome neighborhoods. Science. 351(6280):1454-1458. https://doi.org/10.1126/science.aad9024

MLA

Vancouver

Hnisz D, Weintraub AS, Day DS, Valton A-L, Bak RO, Li CH o.a. Activation of proto-oncogenes by disruption of chromosome neighborhoods. Science. 2016 mar 25;351(6280):1454-1458. https://doi.org/10.1126/science.aad9024

Author

Hnisz, Denes ; Weintraub, Abraham S ; Day, Daniel S ; Valton, Anne-Laure ; Bak, Rasmus O ; Li, Charles H ; Goldmann, Johanna ; Lajoie, Bryan R ; Fan, Zi Peng ; Sigova, Alla A ; Reddy, Jessica ; Borges-Rivera, Diego ; Lee, Tong Ihn ; Jaenisch, Rudolf ; Porteus, Matthew H ; Dekker, Job ; Young, Richard A. / Activation of proto-oncogenes by disruption of chromosome neighborhoods. I: Science. 2016 ; Bind 351, Nr. 6280. s. 1454-1458.

Bibtex

@article{21cc5348ec054a70aa23726814a420ac,
title = "Activation of proto-oncogenes by disruption of chromosome neighborhoods",
abstract = "Oncogenes are activated through well-known chromosomal alterations such as gene fusion, translocation, and focal amplification. In light of recent evidence that the control of key genes depends on chromosome structures called insulated neighborhoods, we investigated whether proto-oncogenes occur within these structures and whether oncogene activation can occur via disruption of insulated neighborhood boundaries in cancer cells. We mapped insulated neighborhoods in T cell acute lymphoblastic leukemia (T-ALL) and found that tumor cell genomes contain recurrent microdeletions that eliminate the boundary sites of insulated neighborhoods containing prominent T-ALL proto-oncogenes. Perturbation of such boundaries in nonmalignant cells was sufficient to activate proto-oncogenes. Mutations affecting chromosome neighborhood boundaries were found in many types of cancer. Thus, oncogene activation can occur via genetic alterations that disrupt insulated neighborhoods in malignant cells.",
keywords = "Chromosome Aberrations, Chromosome Mapping, Gene Expression Regulation, Leukemic, HEK293 Cells, Humans, Mutation, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma, Proto-Oncogenes, Sequence Deletion, Transcriptional Activation, Translocation, Genetic, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't",
author = "Denes Hnisz and Weintraub, {Abraham S} and Day, {Daniel S} and Anne-Laure Valton and Bak, {Rasmus O} and Li, {Charles H} and Johanna Goldmann and Lajoie, {Bryan R} and Fan, {Zi Peng} and Sigova, {Alla A} and Jessica Reddy and Diego Borges-Rivera and Lee, {Tong Ihn} and Rudolf Jaenisch and Porteus, {Matthew H} and Job Dekker and Young, {Richard A}",
note = "Copyright {\circledC} 2016, American Association for the Advancement of Science.",
year = "2016",
month = "3",
day = "25",
doi = "10.1126/science.aad9024",
language = "English",
volume = "351",
pages = "1454--1458",
journal = "Science",
issn = "0036-8075",
publisher = "AMER ASSOC ADVANCEMENT SCIENCE",
number = "6280",

}

RIS

TY - JOUR

T1 - Activation of proto-oncogenes by disruption of chromosome neighborhoods

AU - Hnisz, Denes

AU - Weintraub, Abraham S

AU - Day, Daniel S

AU - Valton, Anne-Laure

AU - Bak, Rasmus O

AU - Li, Charles H

AU - Goldmann, Johanna

AU - Lajoie, Bryan R

AU - Fan, Zi Peng

AU - Sigova, Alla A

AU - Reddy, Jessica

AU - Borges-Rivera, Diego

AU - Lee, Tong Ihn

AU - Jaenisch, Rudolf

AU - Porteus, Matthew H

AU - Dekker, Job

AU - Young, Richard A

N1 - Copyright © 2016, American Association for the Advancement of Science.

PY - 2016/3/25

Y1 - 2016/3/25

N2 - Oncogenes are activated through well-known chromosomal alterations such as gene fusion, translocation, and focal amplification. In light of recent evidence that the control of key genes depends on chromosome structures called insulated neighborhoods, we investigated whether proto-oncogenes occur within these structures and whether oncogene activation can occur via disruption of insulated neighborhood boundaries in cancer cells. We mapped insulated neighborhoods in T cell acute lymphoblastic leukemia (T-ALL) and found that tumor cell genomes contain recurrent microdeletions that eliminate the boundary sites of insulated neighborhoods containing prominent T-ALL proto-oncogenes. Perturbation of such boundaries in nonmalignant cells was sufficient to activate proto-oncogenes. Mutations affecting chromosome neighborhood boundaries were found in many types of cancer. Thus, oncogene activation can occur via genetic alterations that disrupt insulated neighborhoods in malignant cells.

AB - Oncogenes are activated through well-known chromosomal alterations such as gene fusion, translocation, and focal amplification. In light of recent evidence that the control of key genes depends on chromosome structures called insulated neighborhoods, we investigated whether proto-oncogenes occur within these structures and whether oncogene activation can occur via disruption of insulated neighborhood boundaries in cancer cells. We mapped insulated neighborhoods in T cell acute lymphoblastic leukemia (T-ALL) and found that tumor cell genomes contain recurrent microdeletions that eliminate the boundary sites of insulated neighborhoods containing prominent T-ALL proto-oncogenes. Perturbation of such boundaries in nonmalignant cells was sufficient to activate proto-oncogenes. Mutations affecting chromosome neighborhood boundaries were found in many types of cancer. Thus, oncogene activation can occur via genetic alterations that disrupt insulated neighborhoods in malignant cells.

KW - Chromosome Aberrations

KW - Chromosome Mapping

KW - Gene Expression Regulation, Leukemic

KW - HEK293 Cells

KW - Humans

KW - Mutation

KW - Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

KW - Proto-Oncogenes

KW - Sequence Deletion

KW - Transcriptional Activation

KW - Translocation, Genetic

KW - Journal Article

KW - Research Support, N.I.H., Extramural

KW - Research Support, Non-U.S. Gov't

U2 - 10.1126/science.aad9024

DO - 10.1126/science.aad9024

M3 - Journal article

VL - 351

SP - 1454

EP - 1458

JO - Science

JF - Science

SN - 0036-8075

IS - 6280

ER -