A System-Level Feasibility Study of a Lead-Free Ultrasonically Powered Light Delivery Implant for Optogenetics

Saeed Baghaee Ivriq; Kjeld Laursen; Aske Møller Jørgensen; Tanmay Mondal; Milad Zamani; Yasser Rezaeiyan; Brian Corbett; Bo Brummerstedt Iversen; Farshad Moradi

doi:10.1002/aisy.202300527

A System-Level Feasibility Study of a Lead-Free Ultrasonically Powered Light Delivery Implant for Optogenetics

Saeed Baghaee Ivriq^*, Kjeld Laursen, Aske Møller Jørgensen, Tanmay Mondal, Milad Zamani, Yasser Rezaeiyan, Brian Corbett, Bo Brummerstedt Iversen, Farshad Moradi^*

^*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

2 Citationer (Scopus)

Abstract

Body implants play a crucial role in clinical applications, encompassing data acquisition, diagnosis, and disease treatment. However, challenges in size, power consumption, and biocompatibility, particularly in brain applications requiring small, battery-free devices for deep areas, hinder their development. Despite potential advances through simplified, single-purpose devices, such as recording or stimulation, overcoming the power and biocompatibility issues remains a hurdle. Addressing this, the article introduces an ultrasonically powered light delivery implant (LDI) utilizing lead-free piezoelectric material (Li0.08K0.46Na0.46) NbO3 to harvest energy from external ultrasonic waves. The prototype includes a piezoelectric cube, a chip fabricated in 180 nm CMOS technology, and a microscale light-emitting diode (μ-LED) for optogenetics. Achieving an end-to-end efficiency of 0.75%, the LDI holds promise for various optogenetic studies, particularly in animal studies targeting specific brain areas for treating Parkinson’s disease. The delivered optical power on the μ-LED surface, at 14.1mWmm2, presents applicability to diverse studies involving specific opsins.

Originalsprog	Engelsk
Artikelnummer	2300527
Tidsskrift	Advanced Intelligent Systems
Vol/bind	6
Nummer	3
ISSN	2640-4567
DOI	https://doi.org/10.1002/aisy.202300527
Status	Udgivet - mar. 2024

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10.1002/aisy.202300527Licens: CC BY

Citationsformater

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abstract = "Body implants play a crucial role in clinical applications, encompassing data acquisition, diagnosis, and disease treatment. However, challenges in size, power consumption, and biocompatibility, particularly in brain applications requiring small, battery-free devices for deep areas, hinder their development. Despite potential advances through simplified, single-purpose devices, such as recording or stimulation, overcoming the power and biocompatibility issues remains a hurdle. Addressing this, the article introduces an ultrasonically powered light delivery implant (LDI) utilizing lead-free piezoelectric material (Li0.08K0.46Na0.46) NbO3 to harvest energy from external ultrasonic waves. The prototype includes a piezoelectric cube, a chip fabricated in 180 nm CMOS technology, and a microscale light-emitting diode (μ-LED) for optogenetics. Achieving an end-to-end efficiency of 0.75%, the LDI holds promise for various optogenetic studies, particularly in animal studies targeting specific brain areas for treating Parkinson{\textquoteright}s disease. The delivered optical power on the μ-LED surface, at 14.1mWmm2, presents applicability to diverse studies involving specific opsins.",

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author = "{Baghaee Ivriq}, Saeed and Kjeld Laursen and {M{\o}ller J{\o}rgensen}, Aske and Tanmay Mondal and Milad Zamani and Yasser Rezaeiyan and Brian Corbett and Iversen, {Bo Brummerstedt} and Farshad Moradi",

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A System-Level Feasibility Study of a Lead-Free Ultrasonically Powered Light Delivery Implant for Optogenetics. / Baghaee Ivriq, Saeed; Laursen, Kjeld; Møller Jørgensen, Aske et al.
I: Advanced Intelligent Systems , Bind 6, Nr. 3, 2300527, 03.2024.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

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T1 - A System-Level Feasibility Study of a Lead-Free Ultrasonically Powered Light Delivery Implant for Optogenetics

AU - Baghaee Ivriq, Saeed

AU - Laursen, Kjeld

AU - Møller Jørgensen, Aske

AU - Mondal, Tanmay

AU - Zamani, Milad

AU - Rezaeiyan, Yasser

AU - Corbett, Brian

AU - Iversen, Bo Brummerstedt

AU - Moradi, Farshad

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N2 - Body implants play a crucial role in clinical applications, encompassing data acquisition, diagnosis, and disease treatment. However, challenges in size, power consumption, and biocompatibility, particularly in brain applications requiring small, battery-free devices for deep areas, hinder their development. Despite potential advances through simplified, single-purpose devices, such as recording or stimulation, overcoming the power and biocompatibility issues remains a hurdle. Addressing this, the article introduces an ultrasonically powered light delivery implant (LDI) utilizing lead-free piezoelectric material (Li0.08K0.46Na0.46) NbO3 to harvest energy from external ultrasonic waves. The prototype includes a piezoelectric cube, a chip fabricated in 180 nm CMOS technology, and a microscale light-emitting diode (μ-LED) for optogenetics. Achieving an end-to-end efficiency of 0.75%, the LDI holds promise for various optogenetic studies, particularly in animal studies targeting specific brain areas for treating Parkinson’s disease. The delivered optical power on the μ-LED surface, at 14.1mWmm2, presents applicability to diverse studies involving specific opsins.

AB - Body implants play a crucial role in clinical applications, encompassing data acquisition, diagnosis, and disease treatment. However, challenges in size, power consumption, and biocompatibility, particularly in brain applications requiring small, battery-free devices for deep areas, hinder their development. Despite potential advances through simplified, single-purpose devices, such as recording or stimulation, overcoming the power and biocompatibility issues remains a hurdle. Addressing this, the article introduces an ultrasonically powered light delivery implant (LDI) utilizing lead-free piezoelectric material (Li0.08K0.46Na0.46) NbO3 to harvest energy from external ultrasonic waves. The prototype includes a piezoelectric cube, a chip fabricated in 180 nm CMOS technology, and a microscale light-emitting diode (μ-LED) for optogenetics. Achieving an end-to-end efficiency of 0.75%, the LDI holds promise for various optogenetic studies, particularly in animal studies targeting specific brain areas for treating Parkinson’s disease. The delivered optical power on the μ-LED surface, at 14.1mWmm2, presents applicability to diverse studies involving specific opsins.

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KW - biocompatible materials

KW - brain implants

KW - piezoelectric

KW - ultrasonic

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DO - 10.1002/aisy.202300527

M3 - Journal article

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JO - Advanced Intelligent Systems

JF - Advanced Intelligent Systems

IS - 3

M1 - 2300527

ER -

A System-Level Feasibility Study of a Lead-Free Ultrasonically Powered Light Delivery Implant for Optogenetics

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