A survey of sub-Saharan gene flow into the Mediterranean at risk loci for coronary artery disease

TY - JOUR

T1 - A survey of sub-Saharan gene flow into the Mediterranean at risk loci for coronary artery disease

AU - Álvarez-Álvarez, Miguel M.

AU - Zanetti, Daniela

AU - Carreras-Torres, Robert

AU - Moral, Pedro

AU - Athanasiadis, Georgios

PY - 2017/4/1

Y1 - 2017/4/1

N2 - This study tries to find detectable signals of gene flow of Sub-Saharan origin into the Mediterranean in four genomic regions previously associated with coronary artery disease. A total of 366 single-nucleotide polymorphisms were genotyped in 772 individuals from 10 Mediterranean countries. Population structure analyses were performed, in which a noticeable Sub-Saharan component was found in the studied samples. The overall percentage of this Sub-Saharan component presents differences between the two Mediterranean coasts. D-statistics suggest possible Sub-Saharan introgression into one of the studied genomic regions (10q11). We also found differences in linkage disequilibrium patterns between the two Mediterranean coasts, possibly attributable to differential Sub-Saharan admixture. Our results confirm the potentially important role of human demographic history when performing epidemiological studies.

AB - This study tries to find detectable signals of gene flow of Sub-Saharan origin into the Mediterranean in four genomic regions previously associated with coronary artery disease. A total of 366 single-nucleotide polymorphisms were genotyped in 772 individuals from 10 Mediterranean countries. Population structure analyses were performed, in which a noticeable Sub-Saharan component was found in the studied samples. The overall percentage of this Sub-Saharan component presents differences between the two Mediterranean coasts. D-statistics suggest possible Sub-Saharan introgression into one of the studied genomic regions (10q11). We also found differences in linkage disequilibrium patterns between the two Mediterranean coasts, possibly attributable to differential Sub-Saharan admixture. Our results confirm the potentially important role of human demographic history when performing epidemiological studies.

UR - http://www.scopus.com/inward/record.url?scp=85009812374&partnerID=8YFLogxK

U2 - 10.1038/ejhg.2016.200

DO - 10.1038/ejhg.2016.200

M3 - Journal article

C2 - 28098150

AN - SCOPUS:85009812374

SN - 1018-4813

VL - 25

SP - 472

EP - 476

JO - European Journal of Human Genetics

JF - European Journal of Human Genetics

IS - 4

ER -