Aarhus Universitets segl

English

Du er her: AU » Om AU » Organisation » A snapshot of CNVs in the pig genome

Om AU

A snapshot of CNVs in the pig genome

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

Dokumenter

  • PLoS One

    Forlagets udgivne version, 494 KB, PDF-dokument

DOI

  • João Fadista, Danmark
  • Marianne Nygaard, Danmark
  • Lars-Erik Holm, Danmark
  • Bo Thomsen
  • Christian Bendixen, Danmark
  • Molekylær Genetik og Systembiologi
  • Institut for Genetik og Bioteknologi
Recent studies of mammalian genomes have uncovered the extent of copy number variation (CNV) that contributes to phenotypic diversity, including health and disease status. Here we report a first account of CNVs in the pig genome covering part of the chromosomes 4, 7, 14, and 17 already sequenced and assembled. A custom tiling oligonucleotide array was used with a median probe spacing of 409 bp for screening 12 unrelated Duroc boars that are founders of a large family material. After a strict CNV calling pipeline, 37 copy number variable regions (CNVRs) across all four chromosomes were identified, with five CNVRs overlapping segmental duplications, three overlapping pig unigenes and one overlapping a RefSeq pig mRNA. This CNV snapshot analysis is the first of its kind in the porcine genome and constitutes the basis for a better understanding of porcine phenotypes and genotypes with the prospect of identifying important economic traits.
OriginalsprogEngelsk
TidsskriftP L o S One
Vol/bind3
Nummer12
Sider (fra-til)e3916
ISSN1932-6203
DOI
StatusUdgivet - 2008

Se relationer på Aarhus Universitet Citationsformater

Download-statistik

Ingen data tilgængelig

ID: 2572399