A single-domain antibody targeting complement component c5 acts as a selective inhibitor of the terminal pathway of the complement system and thus functionally mimicks the c-terminal domain of the staphylococcus aureusSSL7 protein

Laure Yatime; Nicolas S. Merle; Annette G. Hansen; Niels Anton Friis; Jakob A. Østergaard; Mette Bjerre; Lubka T. Roumenina; Steffen Thiel; Peter Kristensen; Gregers R. Andersen

doi:10.3389/fimmu.2018.02822

A single-domain antibody targeting complement component c5 acts as a selective inhibitor of the terminal pathway of the complement system and thus functionally mimicks the c-terminal domain of the staphylococcus aureusSSL7 protein

Laure Yatime^*, Nicolas S. Merle, Annette G. Hansen, Niels Anton Friis, Jakob A. Østergaard, Mette Bjerre, Lubka T. Roumenina, Steffen Thiel, Peter Kristensen, Gregers R. Andersen

^*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

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Originalsprog	Engelsk
Artikelnummer	2822
Tidsskrift	Frontiers in Immunology
Vol/bind	9
Antal sider	11
ISSN	1664-3224
DOI	https://doi.org/10.3389/fimmu.2018.02822
Status	Udgivet - 29 nov. 2018

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10.3389/fimmu.2018.02822Licens: CC BY

fimmu-09-02822Forlagets udgivne version, 2,62 MBLicens: CC BY

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http://www.scopus.com/inward/record.url?scp=85057611268&partnerID=8YFLogxK

Citationsformater

Yatime, L., Merle, N. S., Hansen, A. G., Friis, N. A., Østergaard, J. A., Bjerre, M., Roumenina, L. T., Thiel, S., Kristensen, P., & Andersen, G. R. (2018). A single-domain antibody targeting complement component c5 acts as a selective inhibitor of the terminal pathway of the complement system and thus functionally mimicks the c-terminal domain of the staphylococcus aureusSSL7 protein. Frontiers in Immunology, 9, Artikel 2822. https://doi.org/10.3389/fimmu.2018.02822

@article{ed20d8a05410466da2d3f78a6cbb3082,

title = "A single-domain antibody targeting complement component c5 acts as a selective inhibitor of the terminal pathway of the complement system and thus functionally mimicks the c-terminal domain of the staphylococcus aureusSSL7 protein",

keywords = "Bacteriolysis, Complement, Hemolysis, Paroxysmal nocturnal hemoglobinuria, Pathogen mimicry, Single-domain antibody, Terminal pathway inhibition",

author = "Laure Yatime and Merle, {Nicolas S.} and Hansen, {Annette G.} and Friis, {Niels Anton} and {\O}stergaard, {Jakob A.} and Mette Bjerre and Roumenina, {Lubka T.} and Steffen Thiel and Peter Kristensen and Andersen, {Gregers R.}",

year = "2018",

month = nov,

day = "29",

doi = "10.3389/fimmu.2018.02822",

language = "English",

volume = "9",

journal = "Frontiers in Immunology",

issn = "1664-3224",

publisher = "Frontiers Research Foundation",

}

Yatime, L, Merle, NS, Hansen, AG, Friis, NA, Østergaard, JA , Bjerre, M, Roumenina, LT, Thiel, S, Kristensen, P & Andersen, GR 2018, 'A single-domain antibody targeting complement component c5 acts as a selective inhibitor of the terminal pathway of the complement system and thus functionally mimicks the c-terminal domain of the staphylococcus aureusSSL7 protein', Frontiers in Immunology, bind 9, 2822. https://doi.org/10.3389/fimmu.2018.02822

A single-domain antibody targeting complement component c5 acts as a selective inhibitor of the terminal pathway of the complement system and thus functionally mimicks the c-terminal domain of the staphylococcus aureusSSL7 protein. / Yatime, Laure; Merle, Nicolas S.; Hansen, Annette G. et al.
I: Frontiers in Immunology, Bind 9, 2822, 29.11.2018.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

TY - JOUR

T1 - A single-domain antibody targeting complement component c5 acts as a selective inhibitor of the terminal pathway of the complement system and thus functionally mimicks the c-terminal domain of the staphylococcus aureusSSL7 protein

AU - Yatime, Laure

AU - Merle, Nicolas S.

AU - Hansen, Annette G.

AU - Friis, Niels Anton

AU - Østergaard, Jakob A.

AU - Bjerre, Mette

AU - Roumenina, Lubka T.

AU - Thiel, Steffen

AU - Kristensen, Peter

AU - Andersen, Gregers R.

PY - 2018/11/29

Y1 - 2018/11/29

KW - Bacteriolysis

KW - Complement

KW - Hemolysis

KW - Paroxysmal nocturnal hemoglobinuria

KW - Pathogen mimicry

KW - Single-domain antibody

KW - Terminal pathway inhibition

UR - http://www.scopus.com/inward/record.url?scp=85057611268&partnerID=8YFLogxK

U2 - 10.3389/fimmu.2018.02822

DO - 10.3389/fimmu.2018.02822

M3 - Journal article

C2 - 30555486

AN - SCOPUS:85057611268

SN - 1664-3224

VL - 9

JO - Frontiers in Immunology

JF - Frontiers in Immunology

M1 - 2822

ER -

Yatime L, Merle NS, Hansen AG, Friis NA, Østergaard JA , Bjerre M et al. A single-domain antibody targeting complement component c5 acts as a selective inhibitor of the terminal pathway of the complement system and thus functionally mimicks the c-terminal domain of the staphylococcus aureusSSL7 protein. Frontiers in Immunology. 2018 nov. 29;9:2822. doi: 10.3389/fimmu.2018.02822