A segregated cortical stream for retinal direction selectivity

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A segregated cortical stream for retinal direction selectivity. / Rasmussen, Rune; Matsumoto, Akihiro; Dahlstrup Sietam, Monica; Yonehara, Keisuke.

I: Nature Communications, Bind 11, Nr. 1, 831, 2020.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

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@article{7d29afddbbcb449a8cc8f1d008eca598,
title = "A segregated cortical stream for retinal direction selectivity",
abstract = "Visual features extracted by retinal circuits are streamed into higher visual areas (HVAs) after being processed along the visual hierarchy. However, how specialized neuronal representations of HVAs are built, based on retinal output channels, remained unclear. Here, we addressed this question by determining the effects of genetically disrupting retinal direction selectivity on motion-evoked responses in visual stages from the retina to HVAs in mice. Direction-selective (DS) cells in the rostrolateral (RL) area that prefer higher temporal frequencies, and that change direction tuning bias as the temporal frequency of a stimulus increases, are selectively reduced upon retinal manipulation. DS cells in the primary visual cortex projecting to area RL, but not to the posteromedial area, were similarly affected. Therefore, the specific connectivity of cortico-cortical projection neurons routes feedforward signaling originating from retinal DS cells preferentially to area RL. We thus identify a cortical processing stream for motion computed in the retina.",
keywords = "CIRCUIT, FUNCTIONAL SPECIALIZATION, GANGLION-CELLS, LATERAL GENICULATE-NUCLEUS, MAPS, MOTION, MOUSE, PRIMARY VISUAL-CORTEX, RESPONSE PROPERTIES, REVEALS",
author = "Rune Rasmussen and Akihiro Matsumoto and {Dahlstrup Sietam}, Monica and Keisuke Yonehara",
year = "2020",
doi = "10.1038/s41467-020-14643-z",
language = "English",
volume = "11",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",
number = "1",

}

RIS

TY - JOUR

T1 - A segregated cortical stream for retinal direction selectivity

AU - Rasmussen, Rune

AU - Matsumoto, Akihiro

AU - Dahlstrup Sietam, Monica

AU - Yonehara, Keisuke

PY - 2020

Y1 - 2020

N2 - Visual features extracted by retinal circuits are streamed into higher visual areas (HVAs) after being processed along the visual hierarchy. However, how specialized neuronal representations of HVAs are built, based on retinal output channels, remained unclear. Here, we addressed this question by determining the effects of genetically disrupting retinal direction selectivity on motion-evoked responses in visual stages from the retina to HVAs in mice. Direction-selective (DS) cells in the rostrolateral (RL) area that prefer higher temporal frequencies, and that change direction tuning bias as the temporal frequency of a stimulus increases, are selectively reduced upon retinal manipulation. DS cells in the primary visual cortex projecting to area RL, but not to the posteromedial area, were similarly affected. Therefore, the specific connectivity of cortico-cortical projection neurons routes feedforward signaling originating from retinal DS cells preferentially to area RL. We thus identify a cortical processing stream for motion computed in the retina.

AB - Visual features extracted by retinal circuits are streamed into higher visual areas (HVAs) after being processed along the visual hierarchy. However, how specialized neuronal representations of HVAs are built, based on retinal output channels, remained unclear. Here, we addressed this question by determining the effects of genetically disrupting retinal direction selectivity on motion-evoked responses in visual stages from the retina to HVAs in mice. Direction-selective (DS) cells in the rostrolateral (RL) area that prefer higher temporal frequencies, and that change direction tuning bias as the temporal frequency of a stimulus increases, are selectively reduced upon retinal manipulation. DS cells in the primary visual cortex projecting to area RL, but not to the posteromedial area, were similarly affected. Therefore, the specific connectivity of cortico-cortical projection neurons routes feedforward signaling originating from retinal DS cells preferentially to area RL. We thus identify a cortical processing stream for motion computed in the retina.

KW - CIRCUIT

KW - FUNCTIONAL SPECIALIZATION

KW - GANGLION-CELLS

KW - LATERAL GENICULATE-NUCLEUS

KW - MAPS

KW - MOTION

KW - MOUSE

KW - PRIMARY VISUAL-CORTEX

KW - RESPONSE PROPERTIES

KW - REVEALS

UR - http://www.scopus.com/inward/record.url?scp=85079337104&partnerID=8YFLogxK

U2 - 10.1038/s41467-020-14643-z

DO - 10.1038/s41467-020-14643-z

M3 - Journal article

C2 - 32047156

VL - 11

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

IS - 1

M1 - 831

ER -