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A recombined Sr26 and Sr61 disease resistance gene stack in wheat encodes unrelated NLR genes

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

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A recombined Sr26 and Sr61 disease resistance gene stack in wheat encodes unrelated NLR genes. / Zhang, Jianping; Hewitt, Timothy C; Boshoff, Willem H P et al.

I: Nature Communications, Bind 12, 3378, 06.2021.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

Harvard

Zhang, J, Hewitt, TC, Boshoff, WHP, Dundas, I, Upadhyaya, N, Li, J, Patpour, M, Chandramohan, S, Pretorius, ZA, Hovmøller, MS, Schnippenkoetter, W, Park, RF, Mago, R, Periyannan, S, Bhatt, D, Hoxha, S, Chakraborty, S, Luo, M, Dodds, P, Steuernagel, B, Wulff, BBH, Ayliffe, M, McIntosh, RA, Zhang, P & Lagudah, ES 2021, 'A recombined Sr26 and Sr61 disease resistance gene stack in wheat encodes unrelated NLR genes', Nature Communications, bind 12, 3378. https://doi.org/10.1038/s41467-021-23738-0

APA

Zhang, J., Hewitt, T. C., Boshoff, W. H. P., Dundas, I., Upadhyaya, N., Li, J., Patpour, M., Chandramohan, S., Pretorius, Z. A., Hovmøller, M. S., Schnippenkoetter, W., Park, R. F., Mago, R., Periyannan, S., Bhatt, D., Hoxha, S., Chakraborty, S., Luo, M., Dodds, P., ... Lagudah, E. S. (2021). A recombined Sr26 and Sr61 disease resistance gene stack in wheat encodes unrelated NLR genes. Nature Communications, 12, [3378]. https://doi.org/10.1038/s41467-021-23738-0

CBE

Zhang J, Hewitt TC, Boshoff WHP, Dundas I, Upadhyaya N, Li J, Patpour M, Chandramohan S, Pretorius ZA, Hovmøller MS, et al. 2021. A recombined Sr26 and Sr61 disease resistance gene stack in wheat encodes unrelated NLR genes. Nature Communications. 12:Article 3378. https://doi.org/10.1038/s41467-021-23738-0

MLA

Zhang, Jianping et al. "A recombined Sr26 and Sr61 disease resistance gene stack in wheat encodes unrelated NLR genes". Nature Communications. 2021. 12. https://doi.org/10.1038/s41467-021-23738-0

Vancouver

Zhang J, Hewitt TC, Boshoff WHP, Dundas I, Upadhyaya N, Li J et al. A recombined Sr26 and Sr61 disease resistance gene stack in wheat encodes unrelated NLR genes. Nature Communications. 2021 jun.;12:3378. doi: 10.1038/s41467-021-23738-0

Author

Zhang, Jianping ; Hewitt, Timothy C ; Boshoff, Willem H P et al. / A recombined Sr26 and Sr61 disease resistance gene stack in wheat encodes unrelated NLR genes. I: Nature Communications. 2021 ; Bind 12.

Bibtex

@article{8b55c55483a04e31a7553302f8a69797,
title = "A recombined Sr26 and Sr61 disease resistance gene stack in wheat encodes unrelated NLR genes",
abstract = "The re-emergence of stem rust on wheat in Europe and Africa is reinforcing the ongoing need for durable resistance gene deployment. Here, we isolate from wheat, Sr26 and Sr61, with both genes independently introduced as alien chromosome introgressions from tall wheat grass (Thinopyrum ponticum). Mutational genomics and targeted exome capture identify Sr26 and Sr61 as separate single genes that encode unrelated (34.8%) nucleotide binding site leucine rich repeat proteins. Sr26 and Sr61 are each validated by transgenic complementation using endogenous and/or heterologous promoter sequences. Sr61 orthologs are absent from current Thinopyrum elongatum and wheat pan genome sequences, contrasting with Sr26 where homologues are present. Using gene-specific markers, we validate the presence of both genes on a single recombinant alien segment developed in wheat. The co-location of these genes on a small non-recombinogenic segment simplifies their deployment as a gene stack and potentially enhances their resistance durability.",
author = "Jianping Zhang and Hewitt, {Timothy C} and Boshoff, {Willem H P} and Ian Dundas and Narayana Upadhyaya and Jianbo Li and Mehran Patpour and Sutha Chandramohan and Pretorius, {Zacharias A} and Hovm{\o}ller, {Mogens St{\o}vring} and Wendelin Schnippenkoetter and Park, {Robert F} and Rohit Mago and Sambasivam Periyannan and Dhara Bhatt and Sami Hoxha and Soma Chakraborty and Ming Luo and Peter Dodds and Burkhard Steuernagel and Wulff, {Brande B H} and Michael Ayliffe and McIntosh, {Robert A} and Peng Zhang and Lagudah, {Evans S}",
year = "2021",
month = jun,
doi = "10.1038/s41467-021-23738-0",
language = "English",
volume = "12",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",

}

RIS

TY - JOUR

T1 - A recombined Sr26 and Sr61 disease resistance gene stack in wheat encodes unrelated NLR genes

AU - Zhang, Jianping

AU - Hewitt, Timothy C

AU - Boshoff, Willem H P

AU - Dundas, Ian

AU - Upadhyaya, Narayana

AU - Li, Jianbo

AU - Patpour, Mehran

AU - Chandramohan, Sutha

AU - Pretorius, Zacharias A

AU - Hovmøller, Mogens Støvring

AU - Schnippenkoetter, Wendelin

AU - Park, Robert F

AU - Mago, Rohit

AU - Periyannan, Sambasivam

AU - Bhatt, Dhara

AU - Hoxha, Sami

AU - Chakraborty, Soma

AU - Luo, Ming

AU - Dodds, Peter

AU - Steuernagel, Burkhard

AU - Wulff, Brande B H

AU - Ayliffe, Michael

AU - McIntosh, Robert A

AU - Zhang, Peng

AU - Lagudah, Evans S

PY - 2021/6

Y1 - 2021/6

N2 - The re-emergence of stem rust on wheat in Europe and Africa is reinforcing the ongoing need for durable resistance gene deployment. Here, we isolate from wheat, Sr26 and Sr61, with both genes independently introduced as alien chromosome introgressions from tall wheat grass (Thinopyrum ponticum). Mutational genomics and targeted exome capture identify Sr26 and Sr61 as separate single genes that encode unrelated (34.8%) nucleotide binding site leucine rich repeat proteins. Sr26 and Sr61 are each validated by transgenic complementation using endogenous and/or heterologous promoter sequences. Sr61 orthologs are absent from current Thinopyrum elongatum and wheat pan genome sequences, contrasting with Sr26 where homologues are present. Using gene-specific markers, we validate the presence of both genes on a single recombinant alien segment developed in wheat. The co-location of these genes on a small non-recombinogenic segment simplifies their deployment as a gene stack and potentially enhances their resistance durability.

AB - The re-emergence of stem rust on wheat in Europe and Africa is reinforcing the ongoing need for durable resistance gene deployment. Here, we isolate from wheat, Sr26 and Sr61, with both genes independently introduced as alien chromosome introgressions from tall wheat grass (Thinopyrum ponticum). Mutational genomics and targeted exome capture identify Sr26 and Sr61 as separate single genes that encode unrelated (34.8%) nucleotide binding site leucine rich repeat proteins. Sr26 and Sr61 are each validated by transgenic complementation using endogenous and/or heterologous promoter sequences. Sr61 orthologs are absent from current Thinopyrum elongatum and wheat pan genome sequences, contrasting with Sr26 where homologues are present. Using gene-specific markers, we validate the presence of both genes on a single recombinant alien segment developed in wheat. The co-location of these genes on a small non-recombinogenic segment simplifies their deployment as a gene stack and potentially enhances their resistance durability.

U2 - 10.1038/s41467-021-23738-0

DO - 10.1038/s41467-021-23738-0

M3 - Journal article

C2 - 34099713

VL - 12

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

M1 - 3378

ER -