A randomized phase III trial for alleviating radiation-induced xerostomia with chewing gum

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Standard

A randomized phase III trial for alleviating radiation-induced xerostomia with chewing gum. / Kaae, Julie Killerup; Stenfeldt, Lone; Hyrup, Birgitte; Brink, Carsten; Eriksen, Jesper Grau.

I: Radiotherapy and Oncology, Bind 142, 2020, s. 72-78.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Kaae, JK, Stenfeldt, L, Hyrup, B, Brink, C & Eriksen, JG 2020, 'A randomized phase III trial for alleviating radiation-induced xerostomia with chewing gum', Radiotherapy and Oncology, bind 142, s. 72-78. https://doi.org/10.1016/j.radonc.2019.09.013

APA

CBE

MLA

Vancouver

Author

Kaae, Julie Killerup ; Stenfeldt, Lone ; Hyrup, Birgitte ; Brink, Carsten ; Eriksen, Jesper Grau. / A randomized phase III trial for alleviating radiation-induced xerostomia with chewing gum. I: Radiotherapy and Oncology. 2020 ; Bind 142. s. 72-78.

Bibtex

@article{e4df91b39718413cb53efbf7197115e1,
title = "A randomized phase III trial for alleviating radiation-induced xerostomia with chewing gum",
abstract = "BACKGROUND AND PURPOSE: Xerostomia is frequently reported after radiotherapy (RT) for head and neck cancer (HNC). The aim of this study was to reduce symptoms of radiation-induced xerostomia in HNC survivors, in which the experimental arm used chewing gum for a month. Primary endpoint was changes in scoring of dry mouth as defined by EORTC QLQ-H&N35 between arms.MATERIALS AND METHODS: Participants with any grade of physician-assessed xerostomia, ≥ six month after RT, disease-free and able to chew gum were, for a month, randomized (2:1) to: (Arm A) daily chewing gum or (Arm B) standard care. Xerostomia-related QOL was assessed using EORTC QLQ-H&N35 and GRIX questionnaires along with measurement of salivary flow and viscosity at inclusion and after one month. The study was registered on ClinicalTrials.gov (NCT03302676).RESULTS: Ninety-one participants were eligible for analysis (Arm A, n = 55; Arm B, n = 36). Comparing categorized scores for symptoms between arms, reduction of dry mouth was significantly higher for Arm A than Arm B (p = 0.05). A reduction in dry mouth scores was observed for xerostomia assessed by EORTC QLQ-H&N35 (question 41) for both arms. Salivary flow increased and viscosity decreased upon five minutes of stimulation within both arms (p < 0.001, respectively), however no significantly difference was observed between arms.CONCLUSION: Categorized scores found reduction of dry mouth to be significantly higher in Arm A than Arm B, but no difference was seen for salivary flow rate and viscosity.",
keywords = "Head and neck cancer, Late morbidity, Quality of life, Radiotherapy, Xerostomia",
author = "Kaae, {Julie Killerup} and Lone Stenfeldt and Birgitte Hyrup and Carsten Brink and Eriksen, {Jesper Grau}",
note = "Copyright {\textcopyright} 2019 Elsevier B.V. All rights reserved.",
year = "2020",
doi = "10.1016/j.radonc.2019.09.013",
language = "English",
volume = "142",
pages = "72--78",
journal = "Radiotherapy & Oncology",
issn = "0167-8140",
publisher = "Elsevier Ireland Ltd.",

}

RIS

TY - JOUR

T1 - A randomized phase III trial for alleviating radiation-induced xerostomia with chewing gum

AU - Kaae, Julie Killerup

AU - Stenfeldt, Lone

AU - Hyrup, Birgitte

AU - Brink, Carsten

AU - Eriksen, Jesper Grau

N1 - Copyright © 2019 Elsevier B.V. All rights reserved.

PY - 2020

Y1 - 2020

N2 - BACKGROUND AND PURPOSE: Xerostomia is frequently reported after radiotherapy (RT) for head and neck cancer (HNC). The aim of this study was to reduce symptoms of radiation-induced xerostomia in HNC survivors, in which the experimental arm used chewing gum for a month. Primary endpoint was changes in scoring of dry mouth as defined by EORTC QLQ-H&N35 between arms.MATERIALS AND METHODS: Participants with any grade of physician-assessed xerostomia, ≥ six month after RT, disease-free and able to chew gum were, for a month, randomized (2:1) to: (Arm A) daily chewing gum or (Arm B) standard care. Xerostomia-related QOL was assessed using EORTC QLQ-H&N35 and GRIX questionnaires along with measurement of salivary flow and viscosity at inclusion and after one month. The study was registered on ClinicalTrials.gov (NCT03302676).RESULTS: Ninety-one participants were eligible for analysis (Arm A, n = 55; Arm B, n = 36). Comparing categorized scores for symptoms between arms, reduction of dry mouth was significantly higher for Arm A than Arm B (p = 0.05). A reduction in dry mouth scores was observed for xerostomia assessed by EORTC QLQ-H&N35 (question 41) for both arms. Salivary flow increased and viscosity decreased upon five minutes of stimulation within both arms (p < 0.001, respectively), however no significantly difference was observed between arms.CONCLUSION: Categorized scores found reduction of dry mouth to be significantly higher in Arm A than Arm B, but no difference was seen for salivary flow rate and viscosity.

AB - BACKGROUND AND PURPOSE: Xerostomia is frequently reported after radiotherapy (RT) for head and neck cancer (HNC). The aim of this study was to reduce symptoms of radiation-induced xerostomia in HNC survivors, in which the experimental arm used chewing gum for a month. Primary endpoint was changes in scoring of dry mouth as defined by EORTC QLQ-H&N35 between arms.MATERIALS AND METHODS: Participants with any grade of physician-assessed xerostomia, ≥ six month after RT, disease-free and able to chew gum were, for a month, randomized (2:1) to: (Arm A) daily chewing gum or (Arm B) standard care. Xerostomia-related QOL was assessed using EORTC QLQ-H&N35 and GRIX questionnaires along with measurement of salivary flow and viscosity at inclusion and after one month. The study was registered on ClinicalTrials.gov (NCT03302676).RESULTS: Ninety-one participants were eligible for analysis (Arm A, n = 55; Arm B, n = 36). Comparing categorized scores for symptoms between arms, reduction of dry mouth was significantly higher for Arm A than Arm B (p = 0.05). A reduction in dry mouth scores was observed for xerostomia assessed by EORTC QLQ-H&N35 (question 41) for both arms. Salivary flow increased and viscosity decreased upon five minutes of stimulation within both arms (p < 0.001, respectively), however no significantly difference was observed between arms.CONCLUSION: Categorized scores found reduction of dry mouth to be significantly higher in Arm A than Arm B, but no difference was seen for salivary flow rate and viscosity.

KW - Head and neck cancer

KW - Late morbidity

KW - Quality of life

KW - Radiotherapy

KW - Xerostomia

U2 - 10.1016/j.radonc.2019.09.013

DO - 10.1016/j.radonc.2019.09.013

M3 - Journal article

C2 - 31606226

VL - 142

SP - 72

EP - 78

JO - Radiotherapy & Oncology

JF - Radiotherapy & Oncology

SN - 0167-8140

ER -