A Randomised Trial Examining Cardiovascular Morbidity and All-Cause Mortality 24 years Following General Health Checks: the Ebeltoft Health Promotion Project (EHPP)

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A Randomised Trial Examining Cardiovascular Morbidity and All-Cause Mortality 24 years Following General Health Checks : the Ebeltoft Health Promotion Project (EHPP). / Bernstorff, Martin; Deichgræber, Pia; Bruun, Niels Henrik; Dalsgaard, Else-Marie; Fenger-Grøn, Morten; Lauritzen, Torsten.

I: BMJ Open, Bind 9, Nr. 10, e030400, 10.2019.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

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@article{ad29cf4431e848958b467e3f5848aba9,
title = "A Randomised Trial Examining Cardiovascular Morbidity and All-Cause Mortality 24 years Following General Health Checks: the Ebeltoft Health Promotion Project (EHPP)",
abstract = "INTRODUCTION: Global prevalence of risk factors for cardiovascular disease (CVD) and all-cause mortality is increasing. Treatments are available but can only be implemented if individuals at risk are identified. General health checks have been suggested to facilitate this process.OBJECTIVES: To examine the long-term effect of population-based general health checks on CVD and all-cause mortality.DESIGN AND SETTING: The Ebeltoft Health Promotion Project (EHPP) is a parallel randomised controlled trial in a Danish primary care setting.PARTICIPANTS: The EHPP enrolled individuals registered in the Civil Registration System as (1) inhabitants of Ebeltoft municipality, (2) registered with a general practitioner (GP) participating in the study and (3) aged 30-49 on 1 January 1991. A total of 3464 individuals were randomised as invitees (n=2000) or non-invitees (n=1464). Of the invitees, 493 declined. As an external control group, we included 1 511 498 Danes living outside the municipality of Ebeltoft.INTERVENTIONS: Invitees were offered a general health check and, if test-results were abnormal, recommended a 15-45 min consultation with their GP. Non-invitees in Ebeltoft received a questionnaire at baseline and were offered a general health check at year 5. The external control group, that is, the remaining Danish population, received routine care only.OUTCOME MEASURES: HRs for CVD and all-cause mortality.RESULTS: Every individual randomised was analysed. When comparing invitees to non-invitees within the municipality of Ebeltoft, we found no significant effect of general health checks on CVD (HR=1.11 (0.88; 1.41)) or all-cause mortality (HR=0.93 (0.75; 1.16)). When comparing invitees to the remaining Danish population, we found similar results for CVD (adjusted HR=0.99 (0.86; 1.13)) and all-cause mortality (adjusted HR=0.96 (0.85; 1.09)).CONCLUSION: We found no effect of general health checks offered to the general population on CVD or all-cause mortality.TRIAL REGISTRATION NUMBER: NCT00145782; 2015-57-0002; 62908, 187.",
keywords = "epidemiology, hypertension, organisation of health services, preventive medicine, primary care, public health",
author = "Martin Bernstorff and Pia Deichgr{\ae}ber and Bruun, {Niels Henrik} and Else-Marie Dalsgaard and Morten Fenger-Gr{\o}n and Torsten Lauritzen",
note = "{\textcopyright} Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.",
year = "2019",
month = oct,
doi = "10.1136/bmjopen-2019-030400",
language = "English",
volume = "9",
journal = "B M J Open",
issn = "2044-6055",
publisher = "BMJ Publishing Group",
number = "10",

}

RIS

TY - JOUR

T1 - A Randomised Trial Examining Cardiovascular Morbidity and All-Cause Mortality 24 years Following General Health Checks

T2 - the Ebeltoft Health Promotion Project (EHPP)

AU - Bernstorff, Martin

AU - Deichgræber, Pia

AU - Bruun, Niels Henrik

AU - Dalsgaard, Else-Marie

AU - Fenger-Grøn, Morten

AU - Lauritzen, Torsten

N1 - © Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

PY - 2019/10

Y1 - 2019/10

N2 - INTRODUCTION: Global prevalence of risk factors for cardiovascular disease (CVD) and all-cause mortality is increasing. Treatments are available but can only be implemented if individuals at risk are identified. General health checks have been suggested to facilitate this process.OBJECTIVES: To examine the long-term effect of population-based general health checks on CVD and all-cause mortality.DESIGN AND SETTING: The Ebeltoft Health Promotion Project (EHPP) is a parallel randomised controlled trial in a Danish primary care setting.PARTICIPANTS: The EHPP enrolled individuals registered in the Civil Registration System as (1) inhabitants of Ebeltoft municipality, (2) registered with a general practitioner (GP) participating in the study and (3) aged 30-49 on 1 January 1991. A total of 3464 individuals were randomised as invitees (n=2000) or non-invitees (n=1464). Of the invitees, 493 declined. As an external control group, we included 1 511 498 Danes living outside the municipality of Ebeltoft.INTERVENTIONS: Invitees were offered a general health check and, if test-results were abnormal, recommended a 15-45 min consultation with their GP. Non-invitees in Ebeltoft received a questionnaire at baseline and were offered a general health check at year 5. The external control group, that is, the remaining Danish population, received routine care only.OUTCOME MEASURES: HRs for CVD and all-cause mortality.RESULTS: Every individual randomised was analysed. When comparing invitees to non-invitees within the municipality of Ebeltoft, we found no significant effect of general health checks on CVD (HR=1.11 (0.88; 1.41)) or all-cause mortality (HR=0.93 (0.75; 1.16)). When comparing invitees to the remaining Danish population, we found similar results for CVD (adjusted HR=0.99 (0.86; 1.13)) and all-cause mortality (adjusted HR=0.96 (0.85; 1.09)).CONCLUSION: We found no effect of general health checks offered to the general population on CVD or all-cause mortality.TRIAL REGISTRATION NUMBER: NCT00145782; 2015-57-0002; 62908, 187.

AB - INTRODUCTION: Global prevalence of risk factors for cardiovascular disease (CVD) and all-cause mortality is increasing. Treatments are available but can only be implemented if individuals at risk are identified. General health checks have been suggested to facilitate this process.OBJECTIVES: To examine the long-term effect of population-based general health checks on CVD and all-cause mortality.DESIGN AND SETTING: The Ebeltoft Health Promotion Project (EHPP) is a parallel randomised controlled trial in a Danish primary care setting.PARTICIPANTS: The EHPP enrolled individuals registered in the Civil Registration System as (1) inhabitants of Ebeltoft municipality, (2) registered with a general practitioner (GP) participating in the study and (3) aged 30-49 on 1 January 1991. A total of 3464 individuals were randomised as invitees (n=2000) or non-invitees (n=1464). Of the invitees, 493 declined. As an external control group, we included 1 511 498 Danes living outside the municipality of Ebeltoft.INTERVENTIONS: Invitees were offered a general health check and, if test-results were abnormal, recommended a 15-45 min consultation with their GP. Non-invitees in Ebeltoft received a questionnaire at baseline and were offered a general health check at year 5. The external control group, that is, the remaining Danish population, received routine care only.OUTCOME MEASURES: HRs for CVD and all-cause mortality.RESULTS: Every individual randomised was analysed. When comparing invitees to non-invitees within the municipality of Ebeltoft, we found no significant effect of general health checks on CVD (HR=1.11 (0.88; 1.41)) or all-cause mortality (HR=0.93 (0.75; 1.16)). When comparing invitees to the remaining Danish population, we found similar results for CVD (adjusted HR=0.99 (0.86; 1.13)) and all-cause mortality (adjusted HR=0.96 (0.85; 1.09)).CONCLUSION: We found no effect of general health checks offered to the general population on CVD or all-cause mortality.TRIAL REGISTRATION NUMBER: NCT00145782; 2015-57-0002; 62908, 187.

KW - epidemiology

KW - hypertension

KW - organisation of health services

KW - preventive medicine

KW - primary care

KW - public health

UR - http://www.scopus.com/inward/record.url?scp=85074249327&partnerID=8YFLogxK

U2 - 10.1136/bmjopen-2019-030400

DO - 10.1136/bmjopen-2019-030400

M3 - Journal article

C2 - 31662372

VL - 9

JO - B M J Open

JF - B M J Open

SN - 2044-6055

IS - 10

M1 - e030400

ER -