A Photoswitchable Inhibitor of the Human Serotonin Transporter

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The human serotonin transporter (hSERT) terminates serotonergic signaling through reuptake of neurotransmitter into presynaptic neurons and is a target for many antidepressant drugs. We describe here the development of a photoswitchable hSERT inhibitor, termed azo-escitalopram, that can be reversibly switched between trans and cis configurations using light of different wavelengths. The dark-adapted trans isomer was found to be significantly less active than the cis isomer, formed upon irradiation.

OriginalsprogEngelsk
TidsskriftACS Chemical Neuroscience
Vol/bind11
Nummer9
Sider (fra-til)1231-1237
Antal sider7
ISSN1948-7193
DOI
StatusUdgivet - maj 2020

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