Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review
A novel acidification mechanism for greatly enhanced oxygen supply to the fish retina. / Damsgaard, Christian; Lauridsen, Henrik; Harter, Till S; Kwan, Garfield T.; Thomsen, Jesper Skovhus; Funder, Anette Marianne Daa; Supuran, Claudiu T; Tresguerres, Martin; Matthews, Phillip GD; Brauner, Colin J.
I: eLife, Bind 9, e58995, 08.2020.Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review
}
TY - JOUR
T1 - A novel acidification mechanism for greatly enhanced oxygen supply to the fish retina
AU - Damsgaard, Christian
AU - Lauridsen, Henrik
AU - Harter, Till S
AU - Kwan, Garfield T.
AU - Thomsen, Jesper Skovhus
AU - Funder, Anette Marianne Daa
AU - Supuran, Claudiu T
AU - Tresguerres, Martin
AU - Matthews, Phillip GD
AU - Brauner, Colin J
PY - 2020/8
Y1 - 2020/8
N2 - Previously, we showed that the evolution of high acuity vision in fishes was directly associated with their unique pH-sensitive hemoglobins that allow O2 to be delivered to the retina at PO2s more than ten-fold that of arterial blood (Damsgaard et al., 2019). Here, we show strong evidence that vacuolar-type H+-ATPase and plasma-accessible carbonic anhydrase in the vascular structure supplying the retina act together to acidify the red blood cell leading to O2 secretion. In vivo data indicate that this pathway primarily affects the oxygenation of the inner retina involved in signal processing and transduction, and that the evolution of this pathway was tightly associated with the morphological expansion of the inner retina. We conclude that this mechanism for retinal oxygenation played a vital role in the adaptive evolution of vision in teleost fishes.
AB - Previously, we showed that the evolution of high acuity vision in fishes was directly associated with their unique pH-sensitive hemoglobins that allow O2 to be delivered to the retina at PO2s more than ten-fold that of arterial blood (Damsgaard et al., 2019). Here, we show strong evidence that vacuolar-type H+-ATPase and plasma-accessible carbonic anhydrase in the vascular structure supplying the retina act together to acidify the red blood cell leading to O2 secretion. In vivo data indicate that this pathway primarily affects the oxygenation of the inner retina involved in signal processing and transduction, and that the evolution of this pathway was tightly associated with the morphological expansion of the inner retina. We conclude that this mechanism for retinal oxygenation played a vital role in the adaptive evolution of vision in teleost fishes.
U2 - 10.7554/eLife.58995
DO - 10.7554/eLife.58995
M3 - Journal article
C2 - 32840208
VL - 9
JO - eLife
JF - eLife
SN - 2050-084X
M1 - e58995
ER -