A novel acidification mechanism for greatly enhanced oxygen supply to the fish retina

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A novel acidification mechanism for greatly enhanced oxygen supply to the fish retina. / Damsgaard, Christian; Lauridsen, Henrik; Harter, Till S; Kwan, Garfield T.; Thomsen, Jesper Skovhus; Funder, Anette Marianne Daa; Supuran, Claudiu T; Tresguerres, Martin; Matthews, Phillip GD; Brauner, Colin J.

I: eLife, Bind 9, e58995, 08.2020.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

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Damsgaard, C., Lauridsen, H., Harter, T. S., Kwan, G. T., Thomsen, J. S., Funder, A. M. D., Supuran, C. T., Tresguerres, M., Matthews, P. GD., & Brauner, C. J. (2020). A novel acidification mechanism for greatly enhanced oxygen supply to the fish retina. eLife, 9, [e58995]. https://doi.org/10.7554/eLife.58995

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Damsgaard, Christian ; Lauridsen, Henrik ; Harter, Till S ; Kwan, Garfield T. ; Thomsen, Jesper Skovhus ; Funder, Anette Marianne Daa ; Supuran, Claudiu T ; Tresguerres, Martin ; Matthews, Phillip GD ; Brauner, Colin J. / A novel acidification mechanism for greatly enhanced oxygen supply to the fish retina. I: eLife. 2020 ; Bind 9.

Bibtex

@article{c163c8ef0ec241d3b2e6029eb8f1b21b,
title = "A novel acidification mechanism for greatly enhanced oxygen supply to the fish retina",
abstract = "Previously, we showed that the evolution of high acuity vision in fishes was directly associated with their unique pH-sensitive hemoglobins that allow O2 to be delivered to the retina at PO2s more than ten-fold that of arterial blood (Damsgaard et al., 2019). Here, we show strong evidence that vacuolar-type H+-ATPase and plasma-accessible carbonic anhydrase in the vascular structure supplying the retina act together to acidify the red blood cell leading to O2 secretion. In vivo data indicate that this pathway primarily affects the oxygenation of the inner retina involved in signal processing and transduction, and that the evolution of this pathway was tightly associated with the morphological expansion of the inner retina. We conclude that this mechanism for retinal oxygenation played a vital role in the adaptive evolution of vision in teleost fishes.",
author = "Christian Damsgaard and Henrik Lauridsen and Harter, {Till S} and Kwan, {Garfield T.} and Thomsen, {Jesper Skovhus} and Funder, {Anette Marianne Daa} and Supuran, {Claudiu T} and Martin Tresguerres and Matthews, {Phillip GD} and Brauner, {Colin J}",
year = "2020",
month = aug,
doi = "10.7554/eLife.58995",
language = "English",
volume = "9",
journal = "eLife",
issn = "2050-084X",
publisher = "eLife Sciences Publications Ltd.",

}

RIS

TY - JOUR

T1 - A novel acidification mechanism for greatly enhanced oxygen supply to the fish retina

AU - Damsgaard, Christian

AU - Lauridsen, Henrik

AU - Harter, Till S

AU - Kwan, Garfield T.

AU - Thomsen, Jesper Skovhus

AU - Funder, Anette Marianne Daa

AU - Supuran, Claudiu T

AU - Tresguerres, Martin

AU - Matthews, Phillip GD

AU - Brauner, Colin J

PY - 2020/8

Y1 - 2020/8

N2 - Previously, we showed that the evolution of high acuity vision in fishes was directly associated with their unique pH-sensitive hemoglobins that allow O2 to be delivered to the retina at PO2s more than ten-fold that of arterial blood (Damsgaard et al., 2019). Here, we show strong evidence that vacuolar-type H+-ATPase and plasma-accessible carbonic anhydrase in the vascular structure supplying the retina act together to acidify the red blood cell leading to O2 secretion. In vivo data indicate that this pathway primarily affects the oxygenation of the inner retina involved in signal processing and transduction, and that the evolution of this pathway was tightly associated with the morphological expansion of the inner retina. We conclude that this mechanism for retinal oxygenation played a vital role in the adaptive evolution of vision in teleost fishes.

AB - Previously, we showed that the evolution of high acuity vision in fishes was directly associated with their unique pH-sensitive hemoglobins that allow O2 to be delivered to the retina at PO2s more than ten-fold that of arterial blood (Damsgaard et al., 2019). Here, we show strong evidence that vacuolar-type H+-ATPase and plasma-accessible carbonic anhydrase in the vascular structure supplying the retina act together to acidify the red blood cell leading to O2 secretion. In vivo data indicate that this pathway primarily affects the oxygenation of the inner retina involved in signal processing and transduction, and that the evolution of this pathway was tightly associated with the morphological expansion of the inner retina. We conclude that this mechanism for retinal oxygenation played a vital role in the adaptive evolution of vision in teleost fishes.

U2 - 10.7554/eLife.58995

DO - 10.7554/eLife.58995

M3 - Journal article

C2 - 32840208

VL - 9

JO - eLife

JF - eLife

SN - 2050-084X

M1 - e58995

ER -