A monomer-trimer model supports intermittent glucagon fibril growth

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Standard

A monomer-trimer model supports intermittent glucagon fibril growth. / Košmrlj, Andrej; Cordsen, Pia; Kyrsting, Anders; Otzen, Daniel; Oddershede, Lene B; Jensen, Mogens H.

I: Scientific Reports, Bind 5, 9005, 11.03.2015, s. 1-6.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Košmrlj, A, Cordsen, P, Kyrsting, A, Otzen, D, Oddershede, LB & Jensen, MH 2015, 'A monomer-trimer model supports intermittent glucagon fibril growth', Scientific Reports, bind 5, 9005, s. 1-6. https://doi.org/10.1038/srep09005

APA

Košmrlj, A., Cordsen, P., Kyrsting, A., Otzen, D., Oddershede, L. B., & Jensen, M. H. (2015). A monomer-trimer model supports intermittent glucagon fibril growth. Scientific Reports, 5, 1-6. [9005]. https://doi.org/10.1038/srep09005

CBE

Košmrlj A, Cordsen P, Kyrsting A, Otzen D, Oddershede LB, Jensen MH. 2015. A monomer-trimer model supports intermittent glucagon fibril growth. Scientific Reports. 5:1-6. https://doi.org/10.1038/srep09005

MLA

Vancouver

Košmrlj A, Cordsen P, Kyrsting A, Otzen D, Oddershede LB, Jensen MH. A monomer-trimer model supports intermittent glucagon fibril growth. Scientific Reports. 2015 mar 11;5:1-6. 9005. https://doi.org/10.1038/srep09005

Author

Košmrlj, Andrej ; Cordsen, Pia ; Kyrsting, Anders ; Otzen, Daniel ; Oddershede, Lene B ; Jensen, Mogens H. / A monomer-trimer model supports intermittent glucagon fibril growth. I: Scientific Reports. 2015 ; Bind 5. s. 1-6.

Bibtex

@article{b5a0351b12784bc3baccedab00e4cff9,
title = "A monomer-trimer model supports intermittent glucagon fibril growth",
abstract = "We investigate in vitro fibrillation kinetics of the hormone peptide glucagon at various concentrations using confocal microscopy and determine the glucagon fibril persistence length 60μm. At all concentrations we observe that periods of individual fibril growth are interrupted by periods of stasis. The growth probability is large at high and low concentrations and is reduced for intermediate glucagon concentrations. To explain this behavior we propose a simple model, where fibrils come in two forms, one built entirely from glucagon monomers and one entirely from glucagon trimers. The opposite building blocks act as fibril growth blockers, and this generic model reproduces experimental behavior well.",
author = "Andrej Košmrlj and Pia Cordsen and Anders Kyrsting and Daniel Otzen and Oddershede, {Lene B} and Jensen, {Mogens H}",
year = "2015",
month = "3",
day = "11",
doi = "10.1038/srep09005",
language = "English",
volume = "5",
pages = "1--6",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",

}

RIS

TY - JOUR

T1 - A monomer-trimer model supports intermittent glucagon fibril growth

AU - Košmrlj, Andrej

AU - Cordsen, Pia

AU - Kyrsting, Anders

AU - Otzen, Daniel

AU - Oddershede, Lene B

AU - Jensen, Mogens H

PY - 2015/3/11

Y1 - 2015/3/11

N2 - We investigate in vitro fibrillation kinetics of the hormone peptide glucagon at various concentrations using confocal microscopy and determine the glucagon fibril persistence length 60μm. At all concentrations we observe that periods of individual fibril growth are interrupted by periods of stasis. The growth probability is large at high and low concentrations and is reduced for intermediate glucagon concentrations. To explain this behavior we propose a simple model, where fibrils come in two forms, one built entirely from glucagon monomers and one entirely from glucagon trimers. The opposite building blocks act as fibril growth blockers, and this generic model reproduces experimental behavior well.

AB - We investigate in vitro fibrillation kinetics of the hormone peptide glucagon at various concentrations using confocal microscopy and determine the glucagon fibril persistence length 60μm. At all concentrations we observe that periods of individual fibril growth are interrupted by periods of stasis. The growth probability is large at high and low concentrations and is reduced for intermediate glucagon concentrations. To explain this behavior we propose a simple model, where fibrils come in two forms, one built entirely from glucagon monomers and one entirely from glucagon trimers. The opposite building blocks act as fibril growth blockers, and this generic model reproduces experimental behavior well.

U2 - 10.1038/srep09005

DO - 10.1038/srep09005

M3 - Journal article

C2 - 25758791

VL - 5

SP - 1

EP - 6

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

M1 - 9005

ER -