A method for mapping regional oxygen and CO2 transfer in the lung

TY - JOUR

T1 - A method for mapping regional oxygen and CO2 transfer in the lung

AU - Johansen, Troels

AU - Winkler, Tilo

AU - Kelly, Vanessa Jane

AU - Osorio-Valencia, Juan Sebastian

AU - Eliyahu Greenblatt, Elliot

AU - Scott Harris, Robert

AU - Venegas, Jose Gabriel

PY - 2016

Y1 - 2016

N2 - This paper presents a novel approach to visualizing regional lung function, through quantitative three-dimensional maps of O 2 and CO 2 transfer rates. These maps describe the contribution of anatomical regions to overall gas exchange and demonstrate how transfer rates of the two gas species' differ regionally.An algorithm for generating such maps is presented, and for illustration, regional gas transfer maps were generated using values of ventilation and perfusion imaged by PET/CT for a healthy subject and an asthmatic patient after bronchoprovocation.In a sensitivity analysis, compartment values of gas transfer showed minor sensitivity to imaging noise in the ventilation and perfusion data, and moderate sensitivity to estimation errors in global lung input values, chiefly global alveolar ventilation, followed by cardiac output and arterial-venous O 2 content difference.Gas transfer maps offer an intuitive display of physiologically relevant lung function at a regional level, the potential for an improved understanding of pulmonary gas exchange in health and disease, and potentially a presurgical evaluation tool.

AB - This paper presents a novel approach to visualizing regional lung function, through quantitative three-dimensional maps of O 2 and CO 2 transfer rates. These maps describe the contribution of anatomical regions to overall gas exchange and demonstrate how transfer rates of the two gas species' differ regionally.An algorithm for generating such maps is presented, and for illustration, regional gas transfer maps were generated using values of ventilation and perfusion imaged by PET/CT for a healthy subject and an asthmatic patient after bronchoprovocation.In a sensitivity analysis, compartment values of gas transfer showed minor sensitivity to imaging noise in the ventilation and perfusion data, and moderate sensitivity to estimation errors in global lung input values, chiefly global alveolar ventilation, followed by cardiac output and arterial-venous O 2 content difference.Gas transfer maps offer an intuitive display of physiologically relevant lung function at a regional level, the potential for an improved understanding of pulmonary gas exchange in health and disease, and potentially a presurgical evaluation tool.

KW - Asthma

KW - CO elimination

KW - Lung imaging

KW - O uptake

KW - Pulmonary gas exchange

KW - Ventilation/perfusion

UR - http://www.scopus.com/inward/record.url?scp=84949254861&partnerID=8YFLogxK

U2 - 10.1016/j.resp.2015.10.017

DO - 10.1016/j.resp.2015.10.017

M3 - Journal article

C2 - 26563454

SN - 1569-9048

VL - 222

SP - 29

EP - 47

JO - Respiratory Physiology & Neurobiology

JF - Respiratory Physiology & Neurobiology

ER -