A metabolomic study of red and processed meat intake and acylcarnitine concentrations in human urine and blood

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  • Roland Wedekind, Section of Nutrition and Metabolism, International Agency for Research on Cancer (IARC-WHO), Lyon, France., Frankrig
  • Agneta Kiss, Section of Nutrition and Metabolism, International Agency for Research on Cancer (IARC-WHO), Lyon, France., Frankrig
  • Pekka Keski-Rahkonen, Section of Nutrition and Metabolism, International Agency for Research on Cancer (IARC-WHO), Lyon, France., Frankrig
  • Vivian Viallon, Section of Nutrition and Metabolism, International Agency for Research on Cancer (IARC-WHO), Lyon, France., Frankrig
  • Joseph A Rothwell, Institut Gustave Roussy, Frankrig
  • Amanda J Cross, Imperial Coll London, Imperial College London, UKDRI, Storbritannien
  • Agnetha Linn Rostgaard-Hansen, Danish Cancer Society Research Center, Danish Cancer Society, Copenhagen, Denmark., Danmark
  • Torkjel M Sandanger, UiT Arctic Univ Norway, UiT The Arctic University of Tromso, Inst Arctic & Marine Biol, Norge
  • Paula Jakszyn, Medical Oncology, Catalan Institute of Oncology, IDIBELL., Spanien
  • Julie A Schmidt, Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK., Storbritannien
  • Valeria Pala, Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy., Italien
  • Roel Vermeulen, Univ Utrecht, Utrecht University Medical Center, Utrecht University, Univ Med Ctr Utrecht, Regenerat Med Ctr, Holland
  • Matthias B Schulze, German Institute of Human Nutrition Potsdam-Rehbruecke, Tyskland
  • Tilman Kühn, German Cancer Research Center (DKFZ), Tyskland
  • Theron Johnson, German Cancer Research Center (DKFZ), Tyskland
  • Antonia Trichopoulou, 1] Hellenic Health Foundation, Athens, Greece [2] Bureau of Epidemiologic Research, Academy of Athens, Athens, Greece., Grækenland
  • Eleni Peppa, 1] Hellenic Health Foundation, Athens, Greece [2] Bureau of Epidemiologic Research, Academy of Athens, Athens, Greece., Grækenland
  • Carlo La Vechia, Hellenic Health Foundation, Athens, Greece., Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Milan, Italy., Grækenland
  • Giovanna Masala, Institute for Cancer Research, Italien
  • Rosario Tumino, Cancer Registry and Histopathology Department , Provincial Health Authority (ASP), Ragusa, Italy., Italien
  • Carlotta Sacerdote, Città della Salute e della Scienza University-Hospital and Center for Cancer Prevention (CPO), Italien
  • Clemens Wittenbecher, German Institute of Human Nutrition Potsdam-Rehbruecke, Tyskland
  • Maria Santucci de Magistris, Azienda Ospedialiera Universitaria (A.O.U.) Federico II, Naples, Italien
  • Christina C Dahm
  • Gianluca Severi, University of Florence, Florence, Italien
  • Francesca Romana Mancini, Institut Gustave Roussy, Frankrig
  • Elisabete Weiderpass, Section of Nutrition and Metabolism, International Agency for Research on Cancer (IARC-WHO), Lyon, France., Frankrig
  • Marc J Gunter, International Agency for Research on Cancer, Frankrig
  • Inge Huybrechts, Section of Nutrition and Metabolism, International Agency for Research on Cancer (IARC-WHO), Lyon, France., Frankrig
  • Augustin Scalbert, Section of Nutrition and Metabolism, International Agency for Research on Cancer (IARC-WHO), Lyon, France., Frankrig

BACKGROUND: Acylcarnitines (ACs) play a major role in fatty acid metabolism and are potential markers of metabolic dysfunction with higher blood concentrations reported in obese and diabetic individuals. Diet, and in particular red and processed meat intake, has been shown to influence AC concentrations but data on the effect of meat consumption on AC concentrations is limited.

OBJECTIVES: To investigate the effect of red and processed meat intake on AC concentrations in plasma and urine using a randomized controlled trial with replication in an observational cohort.

METHODS: In the randomized crossover trial, 12 volunteers successively consumed 2 different diets containing either pork or tofu for 3 d each. A panel of 44 ACs including several oxidized ACs was analyzed by LC-MS in plasma and urine samples collected after the 3-d period. ACs that were associated with pork intake were then measured in urine (n = 474) and serum samples (n = 451) from the European Prospective Investigation into Cancer and nutrition (EPIC) study and tested for associations with habitual red and processed meat intake derived from dietary questionnaires.

RESULTS: In urine samples from the intervention study, pork intake was positively associated with concentrations of 18 short- and medium-chain ACs. Eleven of these were also positively associated with habitual red and processed meat intake in the EPIC cross-sectional study. In blood, C18:0 was positively associated with red meat intake in both the intervention study (q = 0.004, Student's t-test) and the cross-sectional study (q = 0.033, linear regression).

CONCLUSIONS: AC concentrations in urine and blood were associated with red meat intake in both a highly controlled intervention study and in subjects of a cross-sectional study. Our data on the role of meat intake on this important pathway of fatty acid and energy metabolism may help understanding the role of red meat consumption in the etiology of some chronic diseases. This trial was registered at Clinicaltrials.gov as NCT03354130.

OriginalsprogEngelsk
Artikelnummernqaa140
TidsskriftThe American Journal of Clinical Nutrition
Vol/bind112
Nummer2
Sider (fra-til)381-388
Antal sider8
ISSN0002-9165
DOI
StatusUdgivet - 2020

Bibliografisk note

Copyright © The Author(s) on behalf of the American Society for Nutrition 2020.

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