A Mechanic Model and Velocity Optimization of Cell Microinjection

Hongmiao Wei, Liying Su, Huipeng Zhang, Yueqing Yu, Xuping Zhang

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    Abstract

    Microinjection technology has become a common means of injecting foreign materials to a target cell using a sharp-tipped glass micropipette under a microscope in medical and biological related research. Applied forces and injection speed have significant impacts on the success of cell injection. This paper presents the mechanic analysis and injection velocity optimization of cell injection. Firstly, a viscoelastic mechanic model of a compressed cell under puncture is established, the puncture force is analyzed by using ANSYS, and the parameters are identified by MATLAB. Secondly, a linear optimization model is proposed for obtaining the curve of injection velocity versus time by defining the minimum cell deformation as the objective function. Finally, the optimized injection puncture velocity trajectory is calculated by solving the proposed optimization model, and numerical simulations are conducted to demonstrate that the deformation of the cell during the puncture process is reduced with optimized puncture velocity.

    OriginalsprogEngelsk
    TitelProceedings of 2019 IEEE International Conference on Mechatronics and Automation, ICMA 2019
    Antal sider6
    ForlagIEEE
    Publikationsdato2019
    Sider662-667
    Artikelnummer8816221
    ISBN (Trykt)978-1-7281-1698-3
    ISBN (Elektronisk)978-1-7281-1699-0
    DOI
    StatusUdgivet - 2019
    Begivenhed2019 IEEE International Conference on Mechatronics and Automation (ICMA) - Tianjin, Kina
    Varighed: 4 aug. 20197 aug. 2019

    Konference

    Konference2019 IEEE International Conference on Mechatronics and Automation (ICMA)
    Land/OmrådeKina
    ByTianjin
    Periode04/08/201907/08/2019

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