A long‐term energy‐rich diet increases prefrontal BDNF in Sprague‐Dawley rats

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DOI

  • Alessandro Virtuoso, Københavns Universitet
  • ,
  • Pernille Tveden‐Nyborg, Københavns Universitet
  • ,
  • Anne Marie Voigt Schou‐pedersen, Københavns Universitet
  • ,
  • Jens Lykkesfeldt, Københavns Universitet
  • ,
  • Heidi Kaastrup Müller
  • Betina Elfving
  • Dorte Bratbo Sørensen, Københavns Universitet

Findings of the effect of high‐fat feeding including “Cafeteria Diets” (CAF) on brain‐de-rived neurotrophic factor (BDNF) in the hippocampus (HIP) and prefrontal cortex (PFC) in rodents are conflicting. CAF is a non‐standardized, highly palatable energy‐rich diet composed by everyday food items for human consumption and is known to induce metabolic syndrome and obesity in rats. However, the highly palatable nature of CAF may counteract a negative effect of chronic stress on anticipatory behavior and synaptic plasticity in the hippocampus, hence represent a confounding factor (e.g., when evaluating functional effects on the brain). This study investigated the effects of a chronic, restricted access to CAF on BDNF, monoamine neurotransmitters, and redox imbalance in HIP and PFC in male rats. Our results show that CAF induced BDNF and its receptor TrkB in PFC compared to the controls (p < 0.0005). No differences in monoamine neurotransmitters were detected in either PFC or HIP. CAF increased dehydroascorbic acid and decreased malondialdehyde in PFC (p < 0.05), suggesting an early redox imbalance insufficient to induce lipid peroxidation. This study supports that a chronic CAF on a restricted schedule increases BDNF levels in the PFC of rats, highlighting that this may be a suboptimal feeding regime when investigating the effects of diet-induced obesity in the brain and emphasizing this as a point of attention when comparing the findings.

OriginalsprogEngelsk
Artikelnummer126
TidsskriftNutrients
Vol/bind14
Nummer1
Antal sider11
ISSN2072-6643
DOI
StatusUdgivet - jan. 2022

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