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A longitudinal study of serum cobalamins and its binding proteins in lactating women.

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Standard

A longitudinal study of serum cobalamins and its binding proteins in lactating women. / Mørkbak, A L; Ramlau-Hansen, C H; Møller, U K; Henriksen, T B; Møller, Jan; Nexø, E.

I: European Journal of Clinical Nutrition, Bind 61, Nr. 2, 2006, s. 184-9.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Mørkbak, AL, Ramlau-Hansen, CH, Møller, UK, Henriksen, TB, Møller, J & Nexø, E 2006, 'A longitudinal study of serum cobalamins and its binding proteins in lactating women.', European Journal of Clinical Nutrition, bind 61, nr. 2, s. 184-9. https://doi.org/10.1038/sj.ejcn.1602502

APA

Mørkbak, A. L., Ramlau-Hansen, C. H., Møller, U. K., Henriksen, T. B., Møller, J., & Nexø, E. (2006). A longitudinal study of serum cobalamins and its binding proteins in lactating women. European Journal of Clinical Nutrition, 61(2), 184-9. https://doi.org/10.1038/sj.ejcn.1602502

CBE

Mørkbak AL, Ramlau-Hansen CH, Møller UK, Henriksen TB, Møller J, Nexø E. 2006. A longitudinal study of serum cobalamins and its binding proteins in lactating women. European Journal of Clinical Nutrition. 61(2):184-9. https://doi.org/10.1038/sj.ejcn.1602502

MLA

Vancouver

Mørkbak AL, Ramlau-Hansen CH, Møller UK, Henriksen TB, Møller J, Nexø E. A longitudinal study of serum cobalamins and its binding proteins in lactating women. European Journal of Clinical Nutrition. 2006;61(2):184-9. https://doi.org/10.1038/sj.ejcn.1602502

Author

Mørkbak, A L ; Ramlau-Hansen, C H ; Møller, U K ; Henriksen, T B ; Møller, Jan ; Nexø, E. / A longitudinal study of serum cobalamins and its binding proteins in lactating women. I: European Journal of Clinical Nutrition. 2006 ; Bind 61, Nr. 2. s. 184-9.

Bibtex

@article{74428540ce5911dcabe4000ea68e967b,
title = "A longitudinal study of serum cobalamins and its binding proteins in lactating women.",
abstract = "OBJECTIVE: To examine longitudinal changes in serum cobalamins, transcobalamin (TC) and haptocorrin (HC) during lactation and to investigate the influence of vitamin B12 supplementation on these parameters. DESIGN: A 9-month follow-up study. SUBJECTS AND METHODS: Lactating mothers (N=89) including 23 supplemented with vitamin B12 (1-18 microg/daily), 41 partly supplemented and 25 not supplemented. Blood samples collected 3 weeks (baseline) and 4 and 9 months post-partum were analysed for cobalamins, TC and HC. Both the total concentration and the cobalamin-saturated form (holo) of TC and HC were analysed. RESULTS: No significant differences were observed in serum cobalamins or its binding proteins related to supplementation with vitamin B12 or the duration of lactation. Serum cobalamins remained unchanged from 3 weeks to 9 months post-partum. Total TC (holoTC) (median+/-s.e. pmol/l) decreased between 3 weeks (710+/-23 (85+/-12)) and 9 months (602+/-21 (76+/-11)) (P<0.0001 (P=0.0002)), whereas total HC (holoHC) increased from (422+/-11 (300+/-9)) at 4 months to (455+/-13 (317+/-10)) to 9 months post-partum (P<0.0001 (P<0.0001)). CONCLUSION: We report a decrease in TC and an increase in HC during a 9-month period post-partum. No differences were observed between the vitamin B12-supplemented and the unsupplemented groups. Thus, supplementation with vitamin B12 has no impact on the circulating level of serum cobalamins or its binding proteins in a Danish population of lactating mothers. Udgivelsesdato: 2007-Feb",
keywords = "Adult, Dose-Response Relationship, Drug, Female, Follow-Up Studies, Humans, Lactation, Longitudinal Studies, Protein Binding, Transcobalamins, Vitamin B 12, Vitamin B Complex",
author = "M{\o}rkbak, {A L} and Ramlau-Hansen, {C H} and M{\o}ller, {U K} and Henriksen, {T B} and Jan M{\o}ller and E Nex{\o}",
year = "2006",
doi = "10.1038/sj.ejcn.1602502",
language = "English",
volume = "61",
pages = "184--9",
journal = "European Journal of Clinical Nutrition",
issn = "0954-3007",
publisher = "Nature Publishing Group",
number = "2",

}

RIS

TY - JOUR

T1 - A longitudinal study of serum cobalamins and its binding proteins in lactating women.

AU - Mørkbak, A L

AU - Ramlau-Hansen, C H

AU - Møller, U K

AU - Henriksen, T B

AU - Møller, Jan

AU - Nexø, E

PY - 2006

Y1 - 2006

N2 - OBJECTIVE: To examine longitudinal changes in serum cobalamins, transcobalamin (TC) and haptocorrin (HC) during lactation and to investigate the influence of vitamin B12 supplementation on these parameters. DESIGN: A 9-month follow-up study. SUBJECTS AND METHODS: Lactating mothers (N=89) including 23 supplemented with vitamin B12 (1-18 microg/daily), 41 partly supplemented and 25 not supplemented. Blood samples collected 3 weeks (baseline) and 4 and 9 months post-partum were analysed for cobalamins, TC and HC. Both the total concentration and the cobalamin-saturated form (holo) of TC and HC were analysed. RESULTS: No significant differences were observed in serum cobalamins or its binding proteins related to supplementation with vitamin B12 or the duration of lactation. Serum cobalamins remained unchanged from 3 weeks to 9 months post-partum. Total TC (holoTC) (median+/-s.e. pmol/l) decreased between 3 weeks (710+/-23 (85+/-12)) and 9 months (602+/-21 (76+/-11)) (P<0.0001 (P=0.0002)), whereas total HC (holoHC) increased from (422+/-11 (300+/-9)) at 4 months to (455+/-13 (317+/-10)) to 9 months post-partum (P<0.0001 (P<0.0001)). CONCLUSION: We report a decrease in TC and an increase in HC during a 9-month period post-partum. No differences were observed between the vitamin B12-supplemented and the unsupplemented groups. Thus, supplementation with vitamin B12 has no impact on the circulating level of serum cobalamins or its binding proteins in a Danish population of lactating mothers. Udgivelsesdato: 2007-Feb

AB - OBJECTIVE: To examine longitudinal changes in serum cobalamins, transcobalamin (TC) and haptocorrin (HC) during lactation and to investigate the influence of vitamin B12 supplementation on these parameters. DESIGN: A 9-month follow-up study. SUBJECTS AND METHODS: Lactating mothers (N=89) including 23 supplemented with vitamin B12 (1-18 microg/daily), 41 partly supplemented and 25 not supplemented. Blood samples collected 3 weeks (baseline) and 4 and 9 months post-partum were analysed for cobalamins, TC and HC. Both the total concentration and the cobalamin-saturated form (holo) of TC and HC were analysed. RESULTS: No significant differences were observed in serum cobalamins or its binding proteins related to supplementation with vitamin B12 or the duration of lactation. Serum cobalamins remained unchanged from 3 weeks to 9 months post-partum. Total TC (holoTC) (median+/-s.e. pmol/l) decreased between 3 weeks (710+/-23 (85+/-12)) and 9 months (602+/-21 (76+/-11)) (P<0.0001 (P=0.0002)), whereas total HC (holoHC) increased from (422+/-11 (300+/-9)) at 4 months to (455+/-13 (317+/-10)) to 9 months post-partum (P<0.0001 (P<0.0001)). CONCLUSION: We report a decrease in TC and an increase in HC during a 9-month period post-partum. No differences were observed between the vitamin B12-supplemented and the unsupplemented groups. Thus, supplementation with vitamin B12 has no impact on the circulating level of serum cobalamins or its binding proteins in a Danish population of lactating mothers. Udgivelsesdato: 2007-Feb

KW - Adult

KW - Dose-Response Relationship, Drug

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Lactation

KW - Longitudinal Studies

KW - Protein Binding

KW - Transcobalamins

KW - Vitamin B 12

KW - Vitamin B Complex

U2 - 10.1038/sj.ejcn.1602502

DO - 10.1038/sj.ejcn.1602502

M3 - Journal article

C2 - 16900082

VL - 61

SP - 184

EP - 189

JO - European Journal of Clinical Nutrition

JF - European Journal of Clinical Nutrition

SN - 0954-3007

IS - 2

ER -