A longitudinal study of serum cobalamins and its binding proteins in lactating women.

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  • A L Mørkbak, Danmark
  • C H Ramlau-Hansen, Danmark
  • U K Møller, Danmark
  • T B Henriksen, Danmark
  • Jan Møller, Danmark
  • E Nexø
  • Interdisciplinary Nanoscience Center
  • Institut for Kemi
  • Klinisk Biokemisk Afdeling, NBG
  • Klinisk Biokemisk Afdeling, SKS
  • Medicinsk Endokrinologisk Afd., MEA, THG
  • Molekylærbiologisk Institut
OBJECTIVE: To examine longitudinal changes in serum cobalamins, transcobalamin (TC) and haptocorrin (HC) during lactation and to investigate the influence of vitamin B12 supplementation on these parameters. DESIGN: A 9-month follow-up study. SUBJECTS AND METHODS: Lactating mothers (N=89) including 23 supplemented with vitamin B12 (1-18 microg/daily), 41 partly supplemented and 25 not supplemented. Blood samples collected 3 weeks (baseline) and 4 and 9 months post-partum were analysed for cobalamins, TC and HC. Both the total concentration and the cobalamin-saturated form (holo) of TC and HC were analysed. RESULTS: No significant differences were observed in serum cobalamins or its binding proteins related to supplementation with vitamin B12 or the duration of lactation. Serum cobalamins remained unchanged from 3 weeks to 9 months post-partum. Total TC (holoTC) (median+/-s.e. pmol/l) decreased between 3 weeks (710+/-23 (85+/-12)) and 9 months (602+/-21 (76+/-11)) (P<0.0001 (P=0.0002)), whereas total HC (holoHC) increased from (422+/-11 (300+/-9)) at 4 months to (455+/-13 (317+/-10)) to 9 months post-partum (P<0.0001 (P<0.0001)). CONCLUSION: We report a decrease in TC and an increase in HC during a 9-month period post-partum. No differences were observed between the vitamin B12-supplemented and the unsupplemented groups. Thus, supplementation with vitamin B12 has no impact on the circulating level of serum cobalamins or its binding proteins in a Danish population of lactating mothers.
Udgivelsesdato: 2007-Feb
OriginalsprogEngelsk
TidsskriftEuropean Journal of Clinical Nutrition
Vol/bind61
Nummer2
Sider (fra-til)184-9
Antal sider5
ISSN0954-3007
DOI
StatusUdgivet - 2006

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