A longitudinal evaluation of alcohol intake throughout adulthood and colorectal cancer risk

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  • Ana Lucia Mayén, International Agency for Research on Cancer
  • ,
  • Vivian Viallon, International Agency for Research on Cancer
  • ,
  • Edoardo Botteri, Cancer Registry of Norway Institute of Population-Based Cancer Research
  • ,
  • Cecile Proust-Lima, Universite de Bordeaux
  • ,
  • Vincenzo Bagnardi, University of Milan - Bicocca
  • ,
  • Veronica Batista, International Agency for Research on Cancer
  • ,
  • Amanda J. Cross, Imperial College London
  • ,
  • Nasser Laouali, Universite Paris-Saclay
  • ,
  • Conor J. MacDonald, Universite Paris-Saclay
  • ,
  • Gianluca Severi, Universite Paris-Saclay, University of Florence
  • ,
  • Verena Katzke, German Cancer Research Center
  • ,
  • Manuela M. Bergmann, German Institute of Human Nutrition Potsdam-Rehbruecke
  • ,
  • Mattias B. Schulze, German Institute of Human Nutrition Potsdam-Rehbruecke, University of Potsdam
  • ,
  • Anne Tjønneland, Kræftens Bekæmpelse
  • ,
  • Anne Kirstine Eriksen, Kræftens Bekæmpelse
  • ,
  • Christina C. Dahm
  • Christian S. Antoniussen
  • Paula Jakszyn, Institute Catala Oncologia, Ramon Llull University
  • ,
  • Maria Jose Sánchez, Escuela Andaluza de Salud Publica, Instituto de Investigación Biosanitaria ibs, CIBER - Center for Biomedical Research Network, University of Granada
  • ,
  • Pilar Amiano, CIBER - Center for Biomedical Research Network, Ministry of Health of the Basque Government, Instituto de Investigación Sanitaria Biodonostia, Instituto de Salud Carlos III
  • ,
  • Sandra M. Colorado-Yohar, CIBER - Center for Biomedical Research Network, Murcia Regional Health Council, Universidad de Antioquia
  • ,
  • Eva Ardanaz, CIBER - Center for Biomedical Research Network, Navarra Public Health Institute, Navarra Institute for Health Research
  • ,
  • Ruth Travis, University of Oxford
  • ,
  • Domenico Palli, Institute for the Study and Prevention of Cancer
  • ,
  • Sieri Sabina, IRCCS Fondazione Istituto Nazionale per lo studio e la cura dei tumori - Milano
  • ,
  • Rosario Tumino, Hyblean Association for Epidemiological Research AIRE-ONLUS Ragusa
  • ,
  • Fulvio Ricceri, University of Turin
  • ,
  • Salvatore Panico, University of Naples Federico II
  • ,
  • Bas Bueno-de-Mesquita, National Institute of Public Health and the Environment
  • ,
  • Jeroen W.G. Derksen, Utrecht University
  • ,
  • Emily Sonestedt, Lund University
  • ,
  • Anna Winkvist, Umeå University
  • ,
  • Sophia Harlid, Umeå University
  • ,
  • Tonje Braaten, UiT The Arctic University of Norway
  • ,
  • Inger Torhild Gram, UiT The Arctic University of Norway
  • ,
  • Marko Lukic, UiT The Arctic University of Norway
  • ,
  • Mazda Jenab, International Agency for Research on Cancer
  • ,
  • Elio Riboli, Imperial College London
  • ,
  • Heinz Freisling, International Agency for Research on Cancer
  • ,
  • Elisabete Weiderpass, International Agency for Research on Cancer
  • ,
  • Marc J. Gunter, International Agency for Research on Cancer
  • ,
  • Pietro Ferrari, International Agency for Research on Cancer

Background: Alcohol intake is an established risk factor for colorectal cancer (CRC); however, there is limited knowledge on whether changing alcohol drinking habits during adulthood modifies CRC risk. Objective: Leveraging longitudinal exposure assessments on alcohol intake at different ages, we examined the relationship between change in alcohol intake and subsequent CRC risk. Methods: Within the European Prospective Investigation into Cancer and Nutrition, changes in alcohol intake comparing follow-up with baseline assessments were investigated in relation to CRC risk. The analysis included 191,180, participants and 1530 incident CRC cases, with exclusion of the first three years of follow-up to minimize reverse causation. Trajectory profiles of alcohol intake, assessed at ages 20, 30, 40, 50 years, at baseline and during follow-up, were estimated using latent class mixed models and related to CRC risk, including 407,605 participants and 5,008 incident CRC cases. Results: Mean age at baseline was 50.2 years and the follow-up assessment occurred on average 7.1 years later. Compared to stable intake, a 12 g/day increase in alcohol intake during follow-up was positively associated with CRC risk (HR = 1.15, 95%CI 1.04, 1.25), while a 12 g/day reduction was inversely associated with CRC risk (HR = 0.86, 95%CI 0.78, 0.95). Trajectory analysis showed that compared to low alcohol intake, men who increased their alcohol intake from early- to mid- and late-adulthood by up to 30 g/day on average had significantly increased CRC risk (HR = 1.24; 95%CI 1.08, 1.42), while no associations were observed in women. Results were consistent by anatomical subsite. Conclusions: Increasing alcohol intake during mid-to-late adulthood raised CRC risk, while reduction lowered risk.

OriginalsprogEngelsk
TidsskriftEuropean Journal of Epidemiology
Vol/bind37
Nummer9
Sider (fra-til)915-929
Antal sider15
ISSN0393-2990
DOI
StatusUdgivet - sep. 2022

Bibliografisk note

Funding Information:
The coordination of EPIC is financially supported by International Agency for Research on Cancer (IARC) and also by the Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London which has additional infrastructure support provided by the NIHR Imperial Biomedical Research Centre (BRC). The national cohorts are supported by: Danish Cancer Society (Denmark); Ligue Contre le Cancer, Institut Gustave Roussy, Mutuelle Générale de l’Education Nationale, Institut National de la Santé et de la Recherche Médicale (INSERM) (France); German Cancer Aid, German Cancer Research Center (DKFZ), German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Federal Ministry of Education and Research (BMBF) (Germany); Associazione Italiana per la Ricerca sul Cancro-AIRC-Italy, Compagnia di SanPaolo and National Research Council (Italy); Dutch Ministry of Public Health, Welfare and Sports (VWS), Netherlands Cancer Registry (NKR), LK Research Funds, Dutch Prevention Funds, Dutch ZON (Zorg Onderzoek Nederland), World Cancer Research Fund (WCRF), Statistics Netherlands (The Netherlands); Health Research Fund (FIS)—Instituto de Salud Carlos III (ISCIII), Regional Governments of Andalucía, Asturias, Basque Country, Murcia and Navarra, and the Catalan Institute of Oncology—ICO (Spain); Swedish Cancer Society, Swedish Research Council and County Councils of Skåne and Västerbotten (Sweden); Cancer Research UK (14136 to EPIC-Norfolk; C8221/A29017 to EPIC-Oxford), Medical Research Council (1000143 to EPIC-Norfolk; MR/M012190/1 to EPIC-Oxford). (United Kingdom).

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© 2022, Springer Nature B.V.

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