A large population-based investigation into the genetics of susceptibility to gastrointestinal infections and the link between gastrointestinal infections and mental illness

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Standard

A large population-based investigation into the genetics of susceptibility to gastrointestinal infections and the link between gastrointestinal infections and mental illness. / Nudel, Ron; Appadurai, Vivek; Schork, Andrew J; Buil, Alfonso; Bybjerg-Grauholm, Jonas; Børglum, Anders D; Daly, Mark J; Mors, Ole; Hougaard, David M; Mortensen, Preben Bo; Werge, Thomas; Nordentoft, Merete; Thompson, Wesley K; Benros, Michael E.

I: Human Genetics, Bind 139, Nr. 5, 2020, s. 593-604.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Nudel, R, Appadurai, V, Schork, AJ, Buil, A, Bybjerg-Grauholm, J, Børglum, AD, Daly, MJ, Mors, O, Hougaard, DM, Mortensen, PB, Werge, T, Nordentoft, M, Thompson, WK & Benros, ME 2020, 'A large population-based investigation into the genetics of susceptibility to gastrointestinal infections and the link between gastrointestinal infections and mental illness', Human Genetics, bind 139, nr. 5, s. 593-604. https://doi.org/10.1007/s00439-020-02140-8

APA

Nudel, R., Appadurai, V., Schork, A. J., Buil, A., Bybjerg-Grauholm, J., Børglum, A. D., Daly, M. J., Mors, O., Hougaard, D. M., Mortensen, P. B., Werge, T., Nordentoft, M., Thompson, W. K., & Benros, M. E. (2020). A large population-based investigation into the genetics of susceptibility to gastrointestinal infections and the link between gastrointestinal infections and mental illness. Human Genetics, 139(5), 593-604. https://doi.org/10.1007/s00439-020-02140-8

CBE

Nudel R, Appadurai V, Schork AJ, Buil A, Bybjerg-Grauholm J, Børglum AD, Daly MJ, Mors O, Hougaard DM, Mortensen PB, Werge T, Nordentoft M, Thompson WK, Benros ME. 2020. A large population-based investigation into the genetics of susceptibility to gastrointestinal infections and the link between gastrointestinal infections and mental illness. Human Genetics. 139(5):593-604. https://doi.org/10.1007/s00439-020-02140-8

MLA

Vancouver

Author

Nudel, Ron ; Appadurai, Vivek ; Schork, Andrew J ; Buil, Alfonso ; Bybjerg-Grauholm, Jonas ; Børglum, Anders D ; Daly, Mark J ; Mors, Ole ; Hougaard, David M ; Mortensen, Preben Bo ; Werge, Thomas ; Nordentoft, Merete ; Thompson, Wesley K ; Benros, Michael E. / A large population-based investigation into the genetics of susceptibility to gastrointestinal infections and the link between gastrointestinal infections and mental illness. I: Human Genetics. 2020 ; Bind 139, Nr. 5. s. 593-604.

Bibtex

@article{471f5add85eb493e95807c84d68ea4a3,
title = "A large population-based investigation into the genetics of susceptibility to gastrointestinal infections and the link between gastrointestinal infections and mental illness",
abstract = "Gastrointestinal infections can be life threatening, but not much is known about the host's genetic contribution to susceptibility to gastrointestinal infections or the latter's association with psychiatric disorders. We utilized iPSYCH, a genotyped population-based sample of individuals born between 1981 and 2005 comprising 65,534 unrelated Danish individuals (45,889 diagnosed with mental disorders and 19,645 controls from a random population sample) in which all individuals were linked utilizing nationwide population-based registers to estimate the genetic contribution to susceptibility to gastrointestinal infections, identify genetic variants associated with gastrointestinal infections, and examine the link between gastrointestinal infections and psychiatric and neurodevelopmental disorders. The SNP heritability of susceptibility to gastrointestinal infections ranged from 3.7% to 6.4% on the liability scale. Significant correlations were found between gastrointestinal infections and the combined group of mental disorders (OR = 2.09; 95% CI: 1.82-2.4, P = 1.87 × 10-25). Correlations with autism spectrum disorder, attention deficit hyperactivity disorder, and depression were also significant. We identified a genome-wide significant locus associated with susceptibility to gastrointestinal infections (OR = 1.13; 95% CI: 1.08-1.18, P = 2.9 × 10-8), where the top SNP was an eQTL for the ABO gene. The risk allele was associated with reduced ABO expression, providing, for the first time, genetic evidence to support previous studies linking the O blood group to gastrointestinal infections. This study also highlights the importance of integrative work in genetics, psychiatry, infection, and epidemiology on the road to translational medicine.",
author = "Ron Nudel and Vivek Appadurai and Schork, {Andrew J} and Alfonso Buil and Jonas Bybjerg-Grauholm and B{\o}rglum, {Anders D} and Daly, {Mark J} and Ole Mors and Hougaard, {David M} and Mortensen, {Preben Bo} and Thomas Werge and Merete Nordentoft and Thompson, {Wesley K} and Benros, {Michael E}",
year = "2020",
doi = "10.1007/s00439-020-02140-8",
language = "English",
volume = "139",
pages = "593--604",
journal = "Human Genetics",
issn = "0340-6717",
publisher = "Springer",
number = "5",

}

RIS

TY - JOUR

T1 - A large population-based investigation into the genetics of susceptibility to gastrointestinal infections and the link between gastrointestinal infections and mental illness

AU - Nudel, Ron

AU - Appadurai, Vivek

AU - Schork, Andrew J

AU - Buil, Alfonso

AU - Bybjerg-Grauholm, Jonas

AU - Børglum, Anders D

AU - Daly, Mark J

AU - Mors, Ole

AU - Hougaard, David M

AU - Mortensen, Preben Bo

AU - Werge, Thomas

AU - Nordentoft, Merete

AU - Thompson, Wesley K

AU - Benros, Michael E

PY - 2020

Y1 - 2020

N2 - Gastrointestinal infections can be life threatening, but not much is known about the host's genetic contribution to susceptibility to gastrointestinal infections or the latter's association with psychiatric disorders. We utilized iPSYCH, a genotyped population-based sample of individuals born between 1981 and 2005 comprising 65,534 unrelated Danish individuals (45,889 diagnosed with mental disorders and 19,645 controls from a random population sample) in which all individuals were linked utilizing nationwide population-based registers to estimate the genetic contribution to susceptibility to gastrointestinal infections, identify genetic variants associated with gastrointestinal infections, and examine the link between gastrointestinal infections and psychiatric and neurodevelopmental disorders. The SNP heritability of susceptibility to gastrointestinal infections ranged from 3.7% to 6.4% on the liability scale. Significant correlations were found between gastrointestinal infections and the combined group of mental disorders (OR = 2.09; 95% CI: 1.82-2.4, P = 1.87 × 10-25). Correlations with autism spectrum disorder, attention deficit hyperactivity disorder, and depression were also significant. We identified a genome-wide significant locus associated with susceptibility to gastrointestinal infections (OR = 1.13; 95% CI: 1.08-1.18, P = 2.9 × 10-8), where the top SNP was an eQTL for the ABO gene. The risk allele was associated with reduced ABO expression, providing, for the first time, genetic evidence to support previous studies linking the O blood group to gastrointestinal infections. This study also highlights the importance of integrative work in genetics, psychiatry, infection, and epidemiology on the road to translational medicine.

AB - Gastrointestinal infections can be life threatening, but not much is known about the host's genetic contribution to susceptibility to gastrointestinal infections or the latter's association with psychiatric disorders. We utilized iPSYCH, a genotyped population-based sample of individuals born between 1981 and 2005 comprising 65,534 unrelated Danish individuals (45,889 diagnosed with mental disorders and 19,645 controls from a random population sample) in which all individuals were linked utilizing nationwide population-based registers to estimate the genetic contribution to susceptibility to gastrointestinal infections, identify genetic variants associated with gastrointestinal infections, and examine the link between gastrointestinal infections and psychiatric and neurodevelopmental disorders. The SNP heritability of susceptibility to gastrointestinal infections ranged from 3.7% to 6.4% on the liability scale. Significant correlations were found between gastrointestinal infections and the combined group of mental disorders (OR = 2.09; 95% CI: 1.82-2.4, P = 1.87 × 10-25). Correlations with autism spectrum disorder, attention deficit hyperactivity disorder, and depression were also significant. We identified a genome-wide significant locus associated with susceptibility to gastrointestinal infections (OR = 1.13; 95% CI: 1.08-1.18, P = 2.9 × 10-8), where the top SNP was an eQTL for the ABO gene. The risk allele was associated with reduced ABO expression, providing, for the first time, genetic evidence to support previous studies linking the O blood group to gastrointestinal infections. This study also highlights the importance of integrative work in genetics, psychiatry, infection, and epidemiology on the road to translational medicine.

UR - http://www.scopus.com/inward/record.url?scp=85081732814&partnerID=8YFLogxK

U2 - 10.1007/s00439-020-02140-8

DO - 10.1007/s00439-020-02140-8

M3 - Journal article

C2 - 32152699

VL - 139

SP - 593

EP - 604

JO - Human Genetics

JF - Human Genetics

SN - 0340-6717

IS - 5

ER -