A hereditary disposition for bovine peripheral nerve sheath tumors in Danish Holstein cattle

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DOI

  • Anette B. Grossi, Univ Copenhagen, University of Copenhagen, Fac Hlth & Med Sci, Dept Vet Dis Biol, Ukendt
  • Jorgen S. Agerholm, Univ Copenhagen, University of Copenhagen, Dept Large Anim Sci, Fac Med & Hlth Sci, Ukendt
  • Knud Christensen, Univ Copenhagen, University of Copenhagen, Dept Vet Clin & Anim Sci, Fac Med & Hlth Sci, Danmark
  • Henrik E. Jensen, Univ Copenhagen, University of Copenhagen, Fac Hlth & Med Sci, Dept Vet Dis Biol, Danmark
  • Pall S. Leifsson, Univ Copenhagen, University of Copenhagen, Fac Hlth & Med Sci, Dept Vet Dis Biol, Danmark
  • Christian Bendixen
  • Peter Karlskov-Mortensen, Univ Copenhagen, University of Copenhagen, Dept Vet Clin & Anim Sci, Fac Med & Hlth Sci, Danmark
  • Merete Fredholm, Univ Copenhagen, University of Copenhagen, Dept Vet Clin & Anim Sci, Fac Med & Hlth Sci, Danmark

Background: Peripheral nerve sheath tumors (PNSTs) are frequently found in Danish cattle at slaughter. Bovine PNSTs share several gross and histopathological characteristics with the PNSTs in humans with heritable neurofibromatosis syndromes. The aim of the present study was to investigate a possible hereditary disposition to PNSTs in dairy cattle by statistical analysis performed on data from 567 cattle with PNSTs. Furthermore, a preliminary genome-wide association study (GWAS) was performed on DNA isolated from 28 affected and 28 non-affected Holstein cows to identify loci in the bovine genome involved in the development of PNSTs.

Results: PNSTs were significantly more common in the Danish Holstein breed than in other breeds with 0.49% of Danish Holsteins slaughtered during an eight-year-period having PNSTs. PNSTs also occurred significantly more frequently in the offspring of some specific Holstein sires. Examination of three generation pedigrees showed that these sires were genetically related through a widely used US Holstein sire. The PNSTs included in GWAS were histologically classified as neurofibroma-schwannoma (43%), schwannoma (36%) and neurofibroma (21%) and derived from Holstein cows with multiple PNSTs. A single SNP on chromosome 27 reached genome-wide significance.

Conclusions: Gross and histological characteristics of bovine PNSTs are comparable to PNSTs in humans (schwannomatosis). Danish Holsteins are genetically disposed to develop PNSTs but the examined materials are insufficient to allow determination of the mode of inheritance.

OriginalsprogEngelsk
Artikelnummer85
TidsskriftActa Veterinaria Scandinavica (Print)
Vol/bind56
Nummer1
Sider (fra-til)1-6
Antal sider6
ISSN0044-605X
DOI
StatusUdgivet - 10 dec. 2014

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