TY - JOUR
T1 - A genome-wide association study of social trust in 33,882 Danish blood donors
AU - Sequeros, Celia Burgos
AU - Hansen, Thomas Folkmann
AU - Westergaard, David
AU - Louloudis, Ioannis
AU - Kalamajski, Sebastian
AU - Röder, Timo
AU - Rohde, Palle Duun
AU - Schwinn, Michael
AU - Clemmensen, Line Harder
AU - Didriksen, Maria
AU - Nyegaard, Mette
AU - Hjalgrim, Henrik
AU - Nielsen, Kaspar René
AU - Bruun, Mie Topholm
AU - Ostrowski, Sisse Rye
AU - Erikstrup, Christian
AU - Mikkelsen, Susan
AU - Sørensen, Erik
AU - DBDS Genomic Consortium
AU - Brunak, Søren
AU - Banasik, Karina
AU - Giordano, Giuseppe Nicola
AU - Kjerulff, Bertram Dalskov
AU - Kaspersen, Katrine
AU - Boldsen, Jens Kjærgaard
AU - Hindhede, Lotte Aas
N1 - Publisher Copyright:
© 2024, The Author(s).
PY - 2024/1/16
Y1 - 2024/1/16
N2 - Social trust is a heritable trait that has been linked with physical health and longevity. In this study, we performed genome-wide association studies of self-reported social trust in n = 33,882 Danish blood donors. We observed genome-wide and local evidence of genetic similarity with other brain-related phenotypes and estimated the single nucleotide polymorphism-based heritability of trust to be 6% (95% confidence interval = (2.1, 9.9)). In our discovery cohort (n = 25,819), we identified one significantly associated locus (lead variant: rs12776883) in an intronic enhancer region of PLPP4, a gene highly expressed in brain, kidneys, and testes. However, we could not replicate the signal in an independent set of donors who were phenotyped a year later (n = 8063). In the subsequent meta-analysis, we found a second significantly associated variant (rs71543507) in an intergenic enhancer region. Overall, our work confirms that social trust is heritable, and provides an initial look into the genetic factors that influence it.
AB - Social trust is a heritable trait that has been linked with physical health and longevity. In this study, we performed genome-wide association studies of self-reported social trust in n = 33,882 Danish blood donors. We observed genome-wide and local evidence of genetic similarity with other brain-related phenotypes and estimated the single nucleotide polymorphism-based heritability of trust to be 6% (95% confidence interval = (2.1, 9.9)). In our discovery cohort (n = 25,819), we identified one significantly associated locus (lead variant: rs12776883) in an intronic enhancer region of PLPP4, a gene highly expressed in brain, kidneys, and testes. However, we could not replicate the signal in an independent set of donors who were phenotyped a year later (n = 8063). In the subsequent meta-analysis, we found a second significantly associated variant (rs71543507) in an intergenic enhancer region. Overall, our work confirms that social trust is heritable, and provides an initial look into the genetic factors that influence it.
KW - Blood Donors
KW - Denmark
KW - Genetic Predisposition to Disease
KW - Genome-Wide Association Study
KW - Humans
KW - Phenotype
KW - Polymorphism, Single Nucleotide
KW - Trust
U2 - 10.1038/s41598-024-51636-0
DO - 10.1038/s41598-024-51636-0
M3 - Journal article
C2 - 38228779
AN - SCOPUS:85182480285
SN - 2045-2322
VL - 14
JO - Scientific Reports
JF - Scientific Reports
IS - 1
M1 - 1402
ER -