A genome wide association study for milk production traits in Danish Jersey cattle using a 50K SNP chip

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Standard

A genome wide association study for milk production traits in Danish Jersey cattle using a 50K SNP chip. / Mai, M D; Sahana, G; Christiansen, F B; Guldbrandtsen, B.

I: Journal of Animal Science, Bind 88, 2010, s. 3522-3528.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Mai, MD, Sahana, G, Christiansen, FB & Guldbrandtsen, B 2010, 'A genome wide association study for milk production traits in Danish Jersey cattle using a 50K SNP chip', Journal of Animal Science, bind 88, s. 3522-3528. https://doi.org/10.2527/jas.2009-2713

APA

Mai, M. D., Sahana, G., Christiansen, F. B., & Guldbrandtsen, B. (2010). A genome wide association study for milk production traits in Danish Jersey cattle using a 50K SNP chip. Journal of Animal Science, 88, 3522-3528. https://doi.org/10.2527/jas.2009-2713

CBE

MLA

Vancouver

Author

Mai, M D ; Sahana, G ; Christiansen, F B ; Guldbrandtsen, B. / A genome wide association study for milk production traits in Danish Jersey cattle using a 50K SNP chip. I: Journal of Animal Science. 2010 ; Bind 88. s. 3522-3528.

Bibtex

@article{da170dc0b4d211df80f4000ea68e967b,
title = "A genome wide association study for milk production traits in Danish Jersey cattle using a 50K SNP chip",
abstract = "QTL for milk production traits in Danish Jersey cattle were mapped by a genome-wide association analysis using a mixed model. The analysis incorporated 1,039 bulls and 33,090 SNP, and resulted in 98 detected combinations of QTL and traits on 27 BTA. These QTL comprised 30 for milk index, 50 for fat index and 18 for protein index. The evidence presents 33 genome-wide QTL on 14 BTA. Of these, seven had effects on milk index, 21 on fat index and five on protein index. Among the genome-wide QTL, 26 have been previously reported, two on BTA4 and -5 were new for milk index, and five on BTA4, -5, -13, -20, and -29 were new QTL for fat index. We found seven pleiotropic or very closely linked QTL. Most of the QTL were associated with polymorphisms within narrow regions and several may represent the effects of polymorphisms of genes: DGAT1, Casein, ARFGAP3, CYP11B1, and CDC-like kinase 4. By a chromosome wide threshold 65 additional QTL were detected. Many of them are likely to represent QTL. The results are interesting from a breeding perspective and contribute to the search for the genes causing the polymorphisms important for milk production traits.",
keywords = "genome wide association, Jersey dairy cattle, milk, quantitative trait loci",
author = "Mai, {M D} and G Sahana and Christiansen, {F B} and B Guldbrandtsen",
year = "2010",
doi = "10.2527/jas.2009-2713",
language = "English",
volume = "88",
pages = "3522--3528",
journal = "Journal of Animal Science",
issn = "0021-8812",
publisher = "AMER SOC ANIMAL SCIENCE",

}

RIS

TY - JOUR

T1 - A genome wide association study for milk production traits in Danish Jersey cattle using a 50K SNP chip

AU - Mai, M D

AU - Sahana, G

AU - Christiansen, F B

AU - Guldbrandtsen, B

PY - 2010

Y1 - 2010

N2 - QTL for milk production traits in Danish Jersey cattle were mapped by a genome-wide association analysis using a mixed model. The analysis incorporated 1,039 bulls and 33,090 SNP, and resulted in 98 detected combinations of QTL and traits on 27 BTA. These QTL comprised 30 for milk index, 50 for fat index and 18 for protein index. The evidence presents 33 genome-wide QTL on 14 BTA. Of these, seven had effects on milk index, 21 on fat index and five on protein index. Among the genome-wide QTL, 26 have been previously reported, two on BTA4 and -5 were new for milk index, and five on BTA4, -5, -13, -20, and -29 were new QTL for fat index. We found seven pleiotropic or very closely linked QTL. Most of the QTL were associated with polymorphisms within narrow regions and several may represent the effects of polymorphisms of genes: DGAT1, Casein, ARFGAP3, CYP11B1, and CDC-like kinase 4. By a chromosome wide threshold 65 additional QTL were detected. Many of them are likely to represent QTL. The results are interesting from a breeding perspective and contribute to the search for the genes causing the polymorphisms important for milk production traits.

AB - QTL for milk production traits in Danish Jersey cattle were mapped by a genome-wide association analysis using a mixed model. The analysis incorporated 1,039 bulls and 33,090 SNP, and resulted in 98 detected combinations of QTL and traits on 27 BTA. These QTL comprised 30 for milk index, 50 for fat index and 18 for protein index. The evidence presents 33 genome-wide QTL on 14 BTA. Of these, seven had effects on milk index, 21 on fat index and five on protein index. Among the genome-wide QTL, 26 have been previously reported, two on BTA4 and -5 were new for milk index, and five on BTA4, -5, -13, -20, and -29 were new QTL for fat index. We found seven pleiotropic or very closely linked QTL. Most of the QTL were associated with polymorphisms within narrow regions and several may represent the effects of polymorphisms of genes: DGAT1, Casein, ARFGAP3, CYP11B1, and CDC-like kinase 4. By a chromosome wide threshold 65 additional QTL were detected. Many of them are likely to represent QTL. The results are interesting from a breeding perspective and contribute to the search for the genes causing the polymorphisms important for milk production traits.

KW - genome wide association

KW - Jersey dairy cattle

KW - milk

KW - quantitative trait loci

U2 - 10.2527/jas.2009-2713

DO - 10.2527/jas.2009-2713

M3 - Journal article

C2 - 20656975

VL - 88

SP - 3522

EP - 3528

JO - Journal of Animal Science

JF - Journal of Animal Science

SN - 0021-8812

ER -