A genome wide association study for milk production traits in Danish Jersey cattle using a 50K SNP chip

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  • M D Mai, Danmark
  • G Sahana
  • F B Christiansen, Danmark
  • B Guldbrandtsen, Danmark
  • Biostatistik
  • Institut for Genetik og Bioteknologi
QTL for milk production traits in Danish Jersey cattle were mapped by a genome-wide association analysis using a mixed model. The analysis incorporated 1,039 bulls and 33,090 SNP, and resulted in 98 detected combinations of QTL and traits on 27 BTA. These QTL comprised 30 for milk index, 50 for fat index and 18 for protein index. The evidence presents 33 genome-wide QTL on 14 BTA. Of these, seven had effects on milk index, 21 on fat index and five on protein index. Among the genome-wide QTL, 26 have been previously reported, two on BTA4 and -5 were new for milk index, and five on BTA4, -5, -13, -20, and -29 were new QTL for fat index. We found seven pleiotropic or very closely linked QTL. Most of the QTL were associated with polymorphisms within narrow regions and several may represent the effects of polymorphisms of genes: DGAT1, Casein, ARFGAP3, CYP11B1, and CDC-like kinase 4. By a chromosome wide threshold 65 additional QTL were detected. Many of them are likely to represent QTL. The results are interesting from a breeding perspective and contribute to the search for the genes causing the polymorphisms important for milk production traits.
OriginalsprogEngelsk
TidsskriftJournal of Animal Science
Vol/bind88
Sider (fra-til)3522-3528
Antal sider7
ISSN0021-8812
DOI
StatusUdgivet - 2010

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