A cost-effectiveness analysis of identifying Fusobacterium necrophorum in throat swabs followed by antibiotic treatment to reduce the incidence of Lemierre's syndrome and peritonsillar abscesses

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Standard

A cost-effectiveness analysis of identifying Fusobacterium necrophorum in throat swabs followed by antibiotic treatment to reduce the incidence of Lemierre's syndrome and peritonsillar abscesses. / Bank, S; Christensen, Kim; Kristensen, L H; Prag, J.

I: European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, Bind 32, Nr. 1, 01.2013, s. 71-8.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Bank, S, Christensen, K, Kristensen, LH & Prag, J 2013, 'A cost-effectiveness analysis of identifying Fusobacterium necrophorum in throat swabs followed by antibiotic treatment to reduce the incidence of Lemierre's syndrome and peritonsillar abscesses', European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, bind 32, nr. 1, s. 71-8. https://doi.org/10.1007/s10096-012-1715-6

APA

Bank, S., Christensen, K., Kristensen, L. H., & Prag, J. (2013). A cost-effectiveness analysis of identifying Fusobacterium necrophorum in throat swabs followed by antibiotic treatment to reduce the incidence of Lemierre's syndrome and peritonsillar abscesses. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 32(1), 71-8. https://doi.org/10.1007/s10096-012-1715-6

CBE

Bank S, Christensen K, Kristensen LH, Prag J. 2013. A cost-effectiveness analysis of identifying Fusobacterium necrophorum in throat swabs followed by antibiotic treatment to reduce the incidence of Lemierre's syndrome and peritonsillar abscesses. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology. 32(1):71-8. https://doi.org/10.1007/s10096-012-1715-6

MLA

Bank, S o.a.. "A cost-effectiveness analysis of identifying Fusobacterium necrophorum in throat swabs followed by antibiotic treatment to reduce the incidence of Lemierre's syndrome and peritonsillar abscesses". European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology. 2013, 32(1). 71-8. https://doi.org/10.1007/s10096-012-1715-6

Vancouver

Bank S, Christensen K, Kristensen LH, Prag J. A cost-effectiveness analysis of identifying Fusobacterium necrophorum in throat swabs followed by antibiotic treatment to reduce the incidence of Lemierre's syndrome and peritonsillar abscesses. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology. 2013 jan;32(1):71-8. https://doi.org/10.1007/s10096-012-1715-6

Author

Bank, S ; Christensen, Kim ; Kristensen, L H ; Prag, J. / A cost-effectiveness analysis of identifying Fusobacterium necrophorum in throat swabs followed by antibiotic treatment to reduce the incidence of Lemierre's syndrome and peritonsillar abscesses. I: European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology. 2013 ; Bind 32, Nr. 1. s. 71-8.

Bibtex

@article{ce9ed47387ca49528d79b1b77a3a6566,
title = "A cost-effectiveness analysis of identifying Fusobacterium necrophorum in throat swabs followed by antibiotic treatment to reduce the incidence of Lemierre's syndrome and peritonsillar abscesses",
abstract = "The main purpose of this paper was to estimate the cost per quality-adjusted life year (QALY) saved by identifying Fusobacterium necrophorum in throat swabs followed by proper antibiotic treatment, to reduce the incidence of Lemierre's syndrome and peritonsillar abscesses (PTA) originating from a pharyngitis. The second purpose was to estimate the population size required to indicate that antibiotic treatment has an effect. Data from publications and our laboratory were collected. Monte Carlo simulation and one-way sensitivity analysis were used to analyse cost-effectiveness. The cost-effectiveness analysis shows that examining throat swabs from 15- to 24-year-olds for F. necrophorum followed by antibiotic treatment will probably be less costly than most other life-saving medical interventions, with a median cost of US$8,795 per QALY saved. To indicate a reduced incidence of Lemierre's syndrome and PTA in Denmark, the intervention probably has to be followed for up to 5 years. Identifying F. necrophorum in throat swabs from 15- to 24-year-olds followed by proper antibiotic treatment only requires a reduction of 20-25 % in the incidence of Lemierre's syndrome and PTA to be cost-effective. This study warrants further examination of the effect of antibiotic treatment on the outcome of F. necrophorum acute and recurrent pharyngitis, as well as the effect on Lemierre's syndrome and PTA.",
keywords = "Adolescent, Anti-Bacterial Agents, Bacteriological Techniques, Cost of Illness, Cost-Benefit Analysis, Denmark, Female, Fusobacterium Infections, Fusobacterium necrophorum, Humans, Incidence, Lemierre Syndrome, Male, Peritonsillar Abscess, Pharynx, Young Adult",
author = "S Bank and Kim Christensen and Kristensen, {L H} and J Prag",
year = "2013",
month = jan,
doi = "10.1007/s10096-012-1715-6",
language = "English",
volume = "32",
pages = "71--8",
journal = "European Journal of Clinical Microbiology & Infectious Diseases",
issn = "0934-9723",
publisher = "Springer",
number = "1",

}

RIS

TY - JOUR

T1 - A cost-effectiveness analysis of identifying Fusobacterium necrophorum in throat swabs followed by antibiotic treatment to reduce the incidence of Lemierre's syndrome and peritonsillar abscesses

AU - Bank, S

AU - Christensen, Kim

AU - Kristensen, L H

AU - Prag, J

PY - 2013/1

Y1 - 2013/1

N2 - The main purpose of this paper was to estimate the cost per quality-adjusted life year (QALY) saved by identifying Fusobacterium necrophorum in throat swabs followed by proper antibiotic treatment, to reduce the incidence of Lemierre's syndrome and peritonsillar abscesses (PTA) originating from a pharyngitis. The second purpose was to estimate the population size required to indicate that antibiotic treatment has an effect. Data from publications and our laboratory were collected. Monte Carlo simulation and one-way sensitivity analysis were used to analyse cost-effectiveness. The cost-effectiveness analysis shows that examining throat swabs from 15- to 24-year-olds for F. necrophorum followed by antibiotic treatment will probably be less costly than most other life-saving medical interventions, with a median cost of US$8,795 per QALY saved. To indicate a reduced incidence of Lemierre's syndrome and PTA in Denmark, the intervention probably has to be followed for up to 5 years. Identifying F. necrophorum in throat swabs from 15- to 24-year-olds followed by proper antibiotic treatment only requires a reduction of 20-25 % in the incidence of Lemierre's syndrome and PTA to be cost-effective. This study warrants further examination of the effect of antibiotic treatment on the outcome of F. necrophorum acute and recurrent pharyngitis, as well as the effect on Lemierre's syndrome and PTA.

AB - The main purpose of this paper was to estimate the cost per quality-adjusted life year (QALY) saved by identifying Fusobacterium necrophorum in throat swabs followed by proper antibiotic treatment, to reduce the incidence of Lemierre's syndrome and peritonsillar abscesses (PTA) originating from a pharyngitis. The second purpose was to estimate the population size required to indicate that antibiotic treatment has an effect. Data from publications and our laboratory were collected. Monte Carlo simulation and one-way sensitivity analysis were used to analyse cost-effectiveness. The cost-effectiveness analysis shows that examining throat swabs from 15- to 24-year-olds for F. necrophorum followed by antibiotic treatment will probably be less costly than most other life-saving medical interventions, with a median cost of US$8,795 per QALY saved. To indicate a reduced incidence of Lemierre's syndrome and PTA in Denmark, the intervention probably has to be followed for up to 5 years. Identifying F. necrophorum in throat swabs from 15- to 24-year-olds followed by proper antibiotic treatment only requires a reduction of 20-25 % in the incidence of Lemierre's syndrome and PTA to be cost-effective. This study warrants further examination of the effect of antibiotic treatment on the outcome of F. necrophorum acute and recurrent pharyngitis, as well as the effect on Lemierre's syndrome and PTA.

KW - Adolescent

KW - Anti-Bacterial Agents

KW - Bacteriological Techniques

KW - Cost of Illness

KW - Cost-Benefit Analysis

KW - Denmark

KW - Female

KW - Fusobacterium Infections

KW - Fusobacterium necrophorum

KW - Humans

KW - Incidence

KW - Lemierre Syndrome

KW - Male

KW - Peritonsillar Abscess

KW - Pharynx

KW - Young Adult

U2 - 10.1007/s10096-012-1715-6

DO - 10.1007/s10096-012-1715-6

M3 - Journal article

C2 - 22886057

VL - 32

SP - 71

EP - 78

JO - European Journal of Clinical Microbiology & Infectious Diseases

JF - European Journal of Clinical Microbiology & Infectious Diseases

SN - 0934-9723

IS - 1

ER -