A 660-Kb Deletion with Antagonistic Effects on Fertility and Milk Production Segregates at High Frequency in Nordic Red Cattle: Additional Evidence for the Common Occurrence of Balancing Selection in Livestock

Publikation: KonferencebidragPaperForskningpeer review

Standard

A 660-Kb Deletion with Antagonistic Effects on Fertility and Milk Production Segregates at High Frequency in Nordic Red Cattle : Additional Evidence for the Common Occurrence of Balancing Selection in Livestock. / Kadri, Naveen Kumar; Sahana, Goutam; Charlier, Carole; Iso-Touru, Terhi; Guldbrandtsen, Bernt; Karim, Latifa; Nielsen, Ulrik Sander; Panitz, Frank; Pedersen, Gert Aamand; Schulmann, Nina ; Georges, Michel; Vilkki, Johanna; Lund, Mogens Sandø; Druet, Tom.

2014. Paper præsenteret ved 10th World Congress on Genetics Applied to Livestock Production (WCGALP), Vancouver, Canada.

Publikation: KonferencebidragPaperForskningpeer review

Harvard

Kadri, NK, Sahana, G, Charlier, C, Iso-Touru, T, Guldbrandtsen, B, Karim, L, Nielsen, US, Panitz, F, Pedersen, GA, Schulmann, N, Georges, M, Vilkki, J, Lund, MS & Druet, T 2014, 'A 660-Kb Deletion with Antagonistic Effects on Fertility and Milk Production Segregates at High Frequency in Nordic Red Cattle: Additional Evidence for the Common Occurrence of Balancing Selection in Livestock' Paper fremlagt ved, Vancouver, Canada, 17/08/2014 - 22/08/2014, .

APA

Kadri, N. K., Sahana, G., Charlier, C., Iso-Touru, T., Guldbrandtsen, B., Karim, L., ... Druet, T. (2014). A 660-Kb Deletion with Antagonistic Effects on Fertility and Milk Production Segregates at High Frequency in Nordic Red Cattle: Additional Evidence for the Common Occurrence of Balancing Selection in Livestock. Paper præsenteret ved 10th World Congress on Genetics Applied to Livestock Production (WCGALP), Vancouver, Canada.

CBE

Kadri NK, Sahana G, Charlier C, Iso-Touru T, Guldbrandtsen B, Karim L, Nielsen US, Panitz F, Pedersen GA, Schulmann N, Georges M, Vilkki J, Lund MS, Druet T. 2014. A 660-Kb Deletion with Antagonistic Effects on Fertility and Milk Production Segregates at High Frequency in Nordic Red Cattle: Additional Evidence for the Common Occurrence of Balancing Selection in Livestock. Paper præsenteret ved 10th World Congress on Genetics Applied to Livestock Production (WCGALP), Vancouver, Canada.

MLA

Vancouver

Kadri NK, Sahana G, Charlier C, Iso-Touru T, Guldbrandtsen B, Karim L o.a.. A 660-Kb Deletion with Antagonistic Effects on Fertility and Milk Production Segregates at High Frequency in Nordic Red Cattle: Additional Evidence for the Common Occurrence of Balancing Selection in Livestock. 2014. Paper præsenteret ved 10th World Congress on Genetics Applied to Livestock Production (WCGALP), Vancouver, Canada.

Author

Kadri, Naveen Kumar ; Sahana, Goutam ; Charlier, Carole ; Iso-Touru, Terhi ; Guldbrandtsen, Bernt ; Karim, Latifa ; Nielsen, Ulrik Sander ; Panitz, Frank ; Pedersen, Gert Aamand ; Schulmann, Nina ; Georges, Michel ; Vilkki, Johanna ; Lund, Mogens Sandø ; Druet, Tom. / A 660-Kb Deletion with Antagonistic Effects on Fertility and Milk Production Segregates at High Frequency in Nordic Red Cattle : Additional Evidence for the Common Occurrence of Balancing Selection in Livestock. Paper præsenteret ved 10th World Congress on Genetics Applied to Livestock Production (WCGALP), Vancouver, Canada.3 s.

Bibtex

@conference{ba6a033f193d48b7bc655bf40a86cb9f,
title = "A 660-Kb Deletion with Antagonistic Effects on Fertility and Milk Production Segregates at High Frequency in Nordic Red Cattle: Additional Evidence for the Common Occurrence of Balancing Selection in Livestock",
abstract = "The spectacular increase in productivity of dairy cattle has been accompanied by a decline in fertility. It is assumed that this reduction is due to the negative energy balance of high producing cows. We herein describe the dissection of a fertility QTL in Nordic Red cattle to a 660-Kb deletion on BTa 12. The deletion encompasses four genes and affects fertility by causing death in homozygous embryos. Despite its deleterious effect 32{\%} of the Finnish Ayrshire animals carry the deletion. We show that the deletion has a positive effect on milk yield and that the balancing selection maintains it at a higher frequency. Our study demonstrates the Embryonic lethal mutations are partly responsible for decline in fertility and that associated positive effects on milk yield may partly account for the negative genetic correlation.",
keywords = "balancing selection, fertility, embryonic lethals",
author = "Kadri, {Naveen Kumar} and Goutam Sahana and Carole Charlier and Terhi Iso-Touru and Bernt Guldbrandtsen and Latifa Karim and Nielsen, {Ulrik Sander} and Frank Panitz and Pedersen, {Gert Aamand} and Nina Schulmann and Michel Georges and Johanna Vilkki and Lund, {Mogens Sand{\o}} and Tom Druet",
year = "2014",
month = "8",
day = "17",
language = "English",
note = "10th World Congress on Genetics Applied to Livestock Production (WCGALP), WCGALP ; Conference date: 17-08-2014 Through 22-08-2014",

}

RIS

TY - CONF

T1 - A 660-Kb Deletion with Antagonistic Effects on Fertility and Milk Production Segregates at High Frequency in Nordic Red Cattle

T2 - Additional Evidence for the Common Occurrence of Balancing Selection in Livestock

AU - Kadri, Naveen Kumar

AU - Sahana, Goutam

AU - Charlier, Carole

AU - Iso-Touru, Terhi

AU - Guldbrandtsen, Bernt

AU - Karim, Latifa

AU - Nielsen, Ulrik Sander

AU - Panitz, Frank

AU - Pedersen, Gert Aamand

AU - Schulmann, Nina

AU - Georges, Michel

AU - Vilkki, Johanna

AU - Lund, Mogens Sandø

AU - Druet, Tom

PY - 2014/8/17

Y1 - 2014/8/17

N2 - The spectacular increase in productivity of dairy cattle has been accompanied by a decline in fertility. It is assumed that this reduction is due to the negative energy balance of high producing cows. We herein describe the dissection of a fertility QTL in Nordic Red cattle to a 660-Kb deletion on BTa 12. The deletion encompasses four genes and affects fertility by causing death in homozygous embryos. Despite its deleterious effect 32% of the Finnish Ayrshire animals carry the deletion. We show that the deletion has a positive effect on milk yield and that the balancing selection maintains it at a higher frequency. Our study demonstrates the Embryonic lethal mutations are partly responsible for decline in fertility and that associated positive effects on milk yield may partly account for the negative genetic correlation.

AB - The spectacular increase in productivity of dairy cattle has been accompanied by a decline in fertility. It is assumed that this reduction is due to the negative energy balance of high producing cows. We herein describe the dissection of a fertility QTL in Nordic Red cattle to a 660-Kb deletion on BTa 12. The deletion encompasses four genes and affects fertility by causing death in homozygous embryos. Despite its deleterious effect 32% of the Finnish Ayrshire animals carry the deletion. We show that the deletion has a positive effect on milk yield and that the balancing selection maintains it at a higher frequency. Our study demonstrates the Embryonic lethal mutations are partly responsible for decline in fertility and that associated positive effects on milk yield may partly account for the negative genetic correlation.

KW - balancing selection

KW - fertility

KW - embryonic lethals

M3 - Paper

ER -