A 660-Kb Deletion with Antagonistic Effects on Fertility and Milk Production Segregates at High Frequency in Nordic Red Cattle: Additional Evidence for the Common Occurrence of Balancing Selection in Livestock

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  • Naveen Kumar Kadri, University of Liège, Liège, Belgium, Danmark
  • Goutam Sahana
  • Carole Charlier, University of Liège, Liège, Belgium, Belgien
  • Terhi Iso-Touru, MTT Agrifood Research Finland, Jokioinen, Finland
  • Bernt Guldbrandtsen
  • Latifa Karim, University of Liège, Liège, Belgium, Belgien
  • Ulrik Sander Nielsen, Danish Agricultural Advisory Service, Aarhus, Denmark, Danmark
  • Frank Panitz
  • Gert Aamand Pedersen, Nordic Cattle Genetic Evaluation, Aarhus, Denmark, Danmark
  • Nina Schulmann, MTT Agrifood Research Finland, Jokioinen, Finland, Finland
  • Michel Georges, University of Liège, Liège, Belgium, Belgien
  • Johanna Vilkki, MTT Agrifood Research Finland, Jokioinen, Finland, Finland
  • Mogens Sandø Lund
  • Tom Druet, University of Liège, Liège, Belgium, Belgien
The spectacular increase in productivity of dairy cattle has been accompanied by a decline in fertility. It is assumed that this reduction is due to the negative energy balance of high producing cows. We herein describe the dissection of a fertility QTL in Nordic Red cattle to a 660-Kb deletion on BTa 12. The deletion encompasses four genes and affects fertility by causing death in homozygous embryos. Despite its deleterious effect 32% of the Finnish Ayrshire animals carry the deletion. We show that the deletion has a positive effect on milk yield and that the balancing selection maintains it at a higher frequency. Our study demonstrates the Embryonic lethal mutations are partly responsible for decline in fertility and that associated positive effects on milk yield may partly account for the negative genetic correlation.
OriginalsprogEngelsk
Udgivelsesår17 aug. 2014
Antal sider3
StatusUdgivet - 17 aug. 2014
Begivenhed10th World Congress on Genetics Applied to Livestock Production (WCGALP) - The Westin Bayshore, 1601 Bayshore Drive, Vancouver, BC V6G 2V4, Vancouver, Canada
Varighed: 17 aug. 201422 aug. 2014
Konferencens nummer: 10th

Konference

Konference10th World Congress on Genetics Applied to Livestock Production (WCGALP)
Nummer10th
LokationThe Westin Bayshore, 1601 Bayshore Drive, Vancouver, BC V6G 2V4
LandCanada
ByVancouver
Periode17/08/201422/08/2014

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