40 years of IGF1: PAPP-A and cancer

Cheryl A. Conover*, Claus Oxvig

*Corresponding author af dette arbejde

    Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisReviewForskningpeer review

    35 Citationer (Scopus)

    Abstract

    The zinc metalloproteinase, PAPP-A, enhances local insulin-like growth factor (IGF) action through cleavage of inhibitory IGF-binding proteins, thereby increasing IGF available for IGF receptor-mediated cell proliferation, migration and survival. In many tumors, enhanced IGF receptor signaling is associated with tumor growth, invasion and metastasis. We will first discuss PAPP-A structure and function, and post-translational inhibitors of PAPP-A expression or proteolytic activity. We will then review the evidence supporting an important role for PAPP-A in many cancers, including breast, ovarian and lung cancer, and Ewing sarcoma.

    OriginalsprogEngelsk
    TidsskriftJournal of Molecular Endocrinology
    Vol/bind61
    Nummer1
    Sider (fra-til)T1-T10
    Antal sider10
    ISSN0952-5041
    DOI
    StatusUdgivet - 1 jul. 2018

    Fingeraftryk

    Dyk ned i forskningsemnerne om '40 years of IGF1: PAPP-A and cancer'. Sammen danner de et unikt fingeraftryk.

    Citationsformater