3D Electrospun Synthetic Extracellular Matrix for Tissue Regeneration

Yingchun Su; Mette Steen Toftdal; Alice Le Friec; MD Dong; Xiaojun Han; Menglin Chen

doi:10.1002/smsc.202100003

3D Electrospun Synthetic Extracellular Matrix for Tissue Regeneration

Yingchun Su, Mette Steen Toftdal, Alice Le Friec, MD Dong, Xiaojun Han, Menglin Chen

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Review › Forskning › peer review

Abstract

Electrospinning is considered the most versatile micro-/nanofiber fabrication technology. The electrospun fibers hold high surface area, desired mechanical properties, controlled topography, as well as the ease of biochemical functionalization. The 3D electrospun fibrous structures closely mimic the hierarchical architecture and fibrous features of the extracellular matrices (ECM), which greatly contribute to biomaterials design to stimulate tissue regeneration. Herein, the recent advances in electrospinning technology for 3D production of ECM-mimicking biomaterial scaffolds are systematically summarized and the applications in neural, cardiac, bone, skin, and vascularized tissue regeneration are thoroughly discussed. Challenges and future scopes related to each field of tissue regeneration are discussed after each subsection. A few examples of liver, kidney, esophageal tissue engineering are also discussed. Finally, the key challenge in the cost-effective upscale of the electrospinning technique to mature and prevalent industrial applications is outlined. Herein, a systematic, thorough summary of the recent evolutions in electrospinning and its emerging applications for a broad range of tissue regenerations is provided.

Originalsprog	Engelsk
Artikelnummer	2100003
Tidsskrift	Small Science
Vol/bind	1
Nummer	7
ISSN	2688-4046
DOI	https://doi.org/10.1002/smsc.202100003
Status	Udgivet - jul. 2021

Adgang til dokumentet

10.1002/smsc.202100003

Andre filer og links

Link to publication in Scopus

Citationsformater

@article{ba57888df93441d5a61ae79ed12a4833,

title = "3D Electrospun Synthetic Extracellular Matrix for Tissue Regeneration",

abstract = "Electrospinning is considered the most versatile micro-/nanofiber fabrication technology. The electrospun fibers hold high surface area, desired mechanical properties, controlled topography, as well as the ease of biochemical functionalization. The 3D electrospun fibrous structures closely mimic the hierarchical architecture and fibrous features of the extracellular matrices (ECM), which greatly contribute to biomaterials design to stimulate tissue regeneration. Herein, the recent advances in electrospinning technology for 3D production of ECM-mimicking biomaterial scaffolds are systematically summarized and the applications in neural, cardiac, bone, skin, and vascularized tissue regeneration are thoroughly discussed. Challenges and future scopes related to each field of tissue regeneration are discussed after each subsection. A few examples of liver, kidney, esophageal tissue engineering are also discussed. Finally, the key challenge in the cost-effective upscale of the electrospinning technique to mature and prevalent industrial applications is outlined. Herein, a systematic, thorough summary of the recent evolutions in electrospinning and its emerging applications for a broad range of tissue regenerations is provided.",

keywords = "3D electrospun structures, native extracellular matrices, tissue engineering, tissue regeneration",

author = "Yingchun Su and Toftdal, {Mette Steen} and Friec, {Alice Le} and MD Dong and Xiaojun Han and Menglin Chen",

year = "2021",

month = jul,

doi = "10.1002/smsc.202100003",

language = "English",

volume = "1",

journal = "Small Science",

issn = "2688-4046",

publisher = "Wiley",

number = "7",

}

TY - JOUR

T1 - 3D Electrospun Synthetic Extracellular Matrix for Tissue Regeneration

AU - Su, Yingchun

AU - Toftdal, Mette Steen

AU - Friec, Alice Le

AU - Dong, MD

AU - Han, Xiaojun

AU - Chen, Menglin

PY - 2021/7

Y1 - 2021/7

N2 - Electrospinning is considered the most versatile micro-/nanofiber fabrication technology. The electrospun fibers hold high surface area, desired mechanical properties, controlled topography, as well as the ease of biochemical functionalization. The 3D electrospun fibrous structures closely mimic the hierarchical architecture and fibrous features of the extracellular matrices (ECM), which greatly contribute to biomaterials design to stimulate tissue regeneration. Herein, the recent advances in electrospinning technology for 3D production of ECM-mimicking biomaterial scaffolds are systematically summarized and the applications in neural, cardiac, bone, skin, and vascularized tissue regeneration are thoroughly discussed. Challenges and future scopes related to each field of tissue regeneration are discussed after each subsection. A few examples of liver, kidney, esophageal tissue engineering are also discussed. Finally, the key challenge in the cost-effective upscale of the electrospinning technique to mature and prevalent industrial applications is outlined. Herein, a systematic, thorough summary of the recent evolutions in electrospinning and its emerging applications for a broad range of tissue regenerations is provided.

AB - Electrospinning is considered the most versatile micro-/nanofiber fabrication technology. The electrospun fibers hold high surface area, desired mechanical properties, controlled topography, as well as the ease of biochemical functionalization. The 3D electrospun fibrous structures closely mimic the hierarchical architecture and fibrous features of the extracellular matrices (ECM), which greatly contribute to biomaterials design to stimulate tissue regeneration. Herein, the recent advances in electrospinning technology for 3D production of ECM-mimicking biomaterial scaffolds are systematically summarized and the applications in neural, cardiac, bone, skin, and vascularized tissue regeneration are thoroughly discussed. Challenges and future scopes related to each field of tissue regeneration are discussed after each subsection. A few examples of liver, kidney, esophageal tissue engineering are also discussed. Finally, the key challenge in the cost-effective upscale of the electrospinning technique to mature and prevalent industrial applications is outlined. Herein, a systematic, thorough summary of the recent evolutions in electrospinning and its emerging applications for a broad range of tissue regenerations is provided.

KW - 3D electrospun structures

KW - native extracellular matrices

KW - tissue engineering

KW - tissue regeneration

UR - http://www.scopus.com/inward/record.url?scp=85151694122&partnerID=8YFLogxK

U2 - 10.1002/smsc.202100003

DO - 10.1002/smsc.202100003

M3 - Review

SN - 2688-4046

VL - 1

JO - Small Science

JF - Small Science

IS - 7

M1 - 2100003

ER -

3D Electrospun Synthetic Extracellular Matrix for Tissue Regeneration

Abstract

Adgang til dokumentet

Andre filer og links

Fingeraftryk

Citationsformater