3'-5' RNA degradation pathways in human cells

Publikation: Bog/antologi/afhandling/rapportPh.d.-afhandlingForskning

  • Michal Szymon Lubas, Danmark
RNA synthesis and degradation are key steps in the regulation of gene expression in all living organisms. During the course of his PhD studies, Michal Lubas centred his research on the nuclear and cytoplasmic RNA turnover of both noncoding and coding RNAs in human cells. His proteomic studies revealed the interaction network of the main 3'-5' RNA degradation machinery – the RNA exosome complex. One of the key findings was the identification and characterisation of the Nuclear Exosome Targeting (NEXT) complex, important for nuclear functions of the exosome.

Michal Lubas also studied the role of the cytoplasmic 3'-5' exoribonuclease hDIS3L2. Using low throughout and high throughput techniques, both in vivo and in vitro, he characterised the nuclease and disclosed the role of hDIS3L2 in cytoplasmic mRNA metabolism.
OriginalsprogEngelsk
ForlagAarhus University, Faculty of Science and Technology
Antal sider204
Rekvirerende organGraduate School of Science and Technology
StatusUdgivet - 2012

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