糖基化终末产物及其受体在糖尿病大鼠胃组织中的分布 (Distribution of advanced glycation end products and their receptor in the stomach of diabetic rats)

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  • Jia Xing Tian, Graduate School, Beijing University of TCM, Beijing 100029, Department of Endocrinology, Guang′anmen Hospital, China Academy of Chinese Medical Sciences, Kina
  • Jingbo Zhao
  • ,
  • Min Li, Department of Endocrinology, Guang′anmen Hospital, China Academy of Chinese Medical Sciences, Kina
  • Jun Ling Li, Graduate School, Beijing University of TCM, Beijing 100029, Kina
  • Yang Cao, Graduate School, Beijing University of TCM, Beijing 100029, Kina
  • Hans Gregersen, Biomedical Engineering, Chongqing University, Danmark
  • Xiao-Lin Tong, Department of Endocrinology, Guang′anmen Hospital, China Academy of Chinese Medical Sciences, Kina
AIM: To observe the distribution of advanced glycation end products (AGEs) and their receptor (RAGE) in the stomach of diabetic rats. METHODS: Diabetes mellitus (DM) and control (CON) rats were reared for eight weeks. Fasting plasma glucose (FPG), glycated serum protein (GSP) and gastric layer thickness were measured. The expression of AGEs and RAGE was detected by immunohistochemical staining. RESULTS: The thickness of the mucosa (781.47 µm ± 137.82 µm vs 709.85 µm ± 169.41 µm) and submucosa (233.39 µm ± 134.05 µm vs 109.32 µm ± 44.43 µm) increased significantly in the DM group compared with the CON group (P < 0.05). The expression of AGEs and RAGE in the mucosa (5.66 ± 1.90 vs 2.25 ± 0.52, 2.79 ± 0.54 vs 1.70 ± 0.30) and muscle (37.37 ± 7.38 vs 24.32 ± 4.02, 4.26 ± 0.80 vs 3.59 ± 0.37) layers of the stomach was significantly higher in the DM group than in the CON group (P < 0.05). CONCLUSION: The expression of AGEs and RAGE is up-regulated in the stomach of diabetic rats. The increased levels of AGE and RAGE in gastric tissue may contribute to diabetic gastrointestinal dysfunction. © 2015 Baishideng Publishing Group Inc. All rights reserved. Key Words: Diabetes mellitus; Stomach; Advanced glycation end products; Receptor for advanced glycation end products
OriginalsprogKinesisk
TidsskriftShijie Huaren Xiaohua Zazhi
Vol/bind23
Nummer17
Sider (fra-til)2714-2721
Antal sider8
ISSN1009-3079
StatusUdgivet - 18 jun. 2015

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