The rapid urbanization worldwide is still challenging the health burden of the environment we live,although a number of actions are being prompted to promote urban health for today and tomorrow’s cities. Yet, a challenge is still to develop an in-depth investigation to monitor the environmental risks to combat environment-related disease. With the advancement of sensing technology, a body-worn system based environment and health monitor is rapidly gaining ground, which provides a fresh perspective to investigate the health impact of the environment on the individual level.My study hopes to take advantage of the novel technology to explore how the city influences our mental health by measuring the physiological response objectively during physical activity in real urban environments, to develop an in-depth investigation of the role of urban place in public health.