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Proviral latency properties of the different HIV-1 subtypes

Projekter: ProjektForskning

  • Laboratory of Experimental Virology, Department of Medical Microbiology, Center of Infection and Immunity Amsterdam (CINIMA), Academic Medical Center of the University of Amsterdam, The Netherlands
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Beskrivelse

Dutch AIDS Fonds ID: 2008014
PI: Dr. R.E. Jeeninga & Prof. B. Berkhout 01/12/2008 – 01/12/2012
Role on Project: PhD student
This project aimed to identify how the HIV LTR promoter of different HIV subtypes affects viral latency.

Lægmandssprog

In this project we focused on the ability of HIV 1 to establish a latent provirus in proliferating T cells and on how the silent provirus can be activated from latency. HIV-1 latency is a major barrier towards virus eradication from the infected individual. Knowledge on how the latent reservoir is established and understanding the molecular mechanisms that control latency may contribute to the development of therapeutics aiming at prevention and/or eradication of HIV latency.
StatusAfsluttet
Effektiv start/slut dato01/12/200801/12/2012

Aktiviteter

Publikationer

ID: 140876201