Maternal Antibodies to Microbial and Tissue Antigens during Pregnancy and Childhood Epilepsy

Projekter: ProjektForskning

Se relationer på Aarhus Universitet

Beskrivelse

Accumulating data support the view that prenatal exposure to infections can influence adversely nervous system development and cause long-term morbidity, by either direct invasion or by indirect mechanisms. Our new indirect effect hypothesis proposes that some neurological and mental (neuro-mental) disorders – including epilepsy – can result from maternal antibodies to pathogenic glycan epitopes of infectious agents with molecular mimicry to the developing nervous system. High-titered antibodies that cross the more permissive fetal blood-brain barriers could then cause neonatal or delayed clinical ill-effects. It is anticipated that the results of our international/interdiciplinary study could lead to further understanding of causality, provide more specific diagnosis, as well as possible novel preventive and therapeutic interventions.
StatusAfsluttet
Effektiv start/slut dato01/02/200830/09/2011

ID: 128971251