Fertility: Assisted Reproduction and Child Neurodevelopment

Projekter: ProjektForskning

Se relationer på Aarhus Universitet


Infertility affects 10-20% of couples in industrialized countries, and an increasing number seek medical treatment. In developed countries, assisted reproduction techniques (ART) contribute to more than 1% of births – in some countries (e.g. Denmark) up to 9%. Over the last few years, several studies have been published on potentially adverse pregnancy outcomes, however few studies have been performed on the neuropsychological development of these children. The infertility of the parents, the higher prevalence of chromosomal abnormalities in subfertile men and the possible increased risks of genomic imprinting disorders are among the biologically plausible reasons for increased vigilance.
1. To investigate the effect of ART on child IQ, attention, behavior and executive functions at age 5.
2. To investigate the effect of ART on the child risk of mental retardation.
Ad 1) A study of 1628 mother and child pairs who participated in the Lifestyle During Pregnancy Study and who completed a neuropsychological test battery including validated tests of child IQ and attention, and self-administered tests of behavior and executive function. Exposure information is obtained from the Danish National Birth Cohort along with information on a set of potentially confounding factors.
Ad 2) A study of 33.139 children conceived after ART and 555.828 children born after natural conception. The risk of mental disorders is compared between the two groups. Exposure information is obtained from the Danish IVF registry and the Danish drug prescription registry and outcomes from the Danish National Patient Registry.
Effektiv start/slut dato01/03/201128/02/2014



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