Congenital malformation and cancer

Projekter: ProjektForskning

Se relationer på Aarhus Universitet


Studies on clustering of diseases in families have given important clues to raise both genetic and environmental hypotheses. Finding common causes for different diseases may point to common pathways and may lead to discoveries of new ways to prevent and treat diseases.
It has long been known that people with certain congenital malformations have a higher cancer risk. Children with Down’s syndrome have, for example, an increased risk of leukemia, and children born with cryptorchidism have an increased risk of cancer of the testis.
Both environmental risk factors and genetic susceptibility may affect two or more generations. A well-known example is diethylstilbestrol (DES). Exposure to DES during pregnancy is associated with congenital malformations in the offspring and with cancers in both offspring and mothers. Paternal exposure to pesticide increases the risk of cancer in fathers and also the risk of congenital malformations in offspring if exposure is around the time of conception. In recent years, numerous substances have been identified as "endocrine disruptors" with possible adverse health outcomes. There is also a growing body of evidence that links cancer with genes and pathways that are required for normal embryonic development.
Published results concerning the association between congenital malformations and risk of cancer in the parents or other relatives of the malformed child have not been consistent. Our previous population-based case-control study was based on older data and found a higher risk of lymphomas and leukaemia in parents who had a child with cleft lip/palate. A similar population based cohort study from Norway and Sweden showed other potential clusters, which indicate that these studies have to be replicated to provide reliable results.
We propose a study that examines cancer risks in parents and siblings of a child with congenital malformations. The study will be based on Danish Register data with about 162,000 pairs of couples who have at least one child with congenital malformations. The number of unexposed parents is 10 times of that. This study will have more power than our previous studies and the Danish National Birth Cohort will allow better adjustment for potential confounders in a sub-analysis.
Effektiv start/slut dato01/01/201131/12/2014

ID: 128971265