The Arctic is warming three times faster than the world as a whole, melting the Greenland Ice Sheets at an extraordinary rate. A recent study suggests, that freshwater run-off from the Ice Sheet exports large amounts of mercury to the surrounding fjords and open ocean. However, the impact of climate change and mercury pollution remains poorly understood. In this project I will explore three questions related to this mercury pollution: (i) Do interactions between freshwater and mercury pollution decrease fitness and performance in marine organisms? (ii) Are the physiological responses expressed at all biological levels, from molecular to whole-animal? and (iii) Have local populations adapted to stress from freshwater and mercury, hereby increasing fitness and resilience?