Institut for Biomedicin

Yonglun Luo

Lektor, !!Associate Professor

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Yonglun Luo

!!Associate Professor, Lektor

  • Institut for Biomedicin - Forskning og uddannelse, Skou-bygningen
  • DANDRITE
Postaddresse:
Høegh-Guldbergs Gade 10
1116, 152
8000
Aarhus C
Danmark
Postaddresse:
Gustav Wieds Vej 10
8000
Aarhus C
Danmark

E-mail: alun@biomed.au.dk

Mobil: +4522411944

Telefon: +4522411944

Curriculum Vitae

2003.9 -2006.7 China Agricultural University, molecular biology and biochemistry, Bachelor

2006.9-2009.7 Chinese Academy of Sciences, behavioral genetics, Master in Genetics

2008.12-2011.11 Aarhus University, PhD in Medicine

2011.12-2012.03 Research assistant, Department of Biomedicine, Aarhus University

2012.04-2012.07 Postdoc, Department of Biomedicine, Aarhus University

2012.07-2014.06 STAR postdoc, Novo Nordisk A/S; Department of Biomedicine, Aarhus University

Ansættelse

Lektor

Institut for Biomedicin - Forskning og uddannelse, Skou-bygningen

Aarhus Universitet

Aarhus C, Danmark

1 maj 2018 → nu

!!Associate Professor

DANDRITE

Aarhus Universitet

Aarhus C, Danmark

27 maj 2020 → nu

!!Associate Professor

DANDRITE

Aarhus Universitet

Aarhus C, Danmark

8 apr. 202024 maj 2020

Lektor

Institut for Biomedicin - Forskning og uddannelse, Øst

Aarhus Universitet

Aarhus C, Danmark

21 okt. 20171 maj 2018

Institut for Biomedicin - Forskning og uddannelse, Øst

Aarhus Universitet

Aarhus C, Danmark

11 nov. 20146 feb. 2018

Institut for Biomedicin - Forskning og uddannelse, Øst

Aarhus Universitet

Aarhus C, Danmark

2 jun. 20173 okt. 2017

Institut for Biomedicin - Forskning og uddannelse, Øst

Aarhus Universitet

Aarhus C, Danmark

9 maj 201411 nov. 2014

Institut for Biomedicin - Forskning og uddannelse, Øst

Aarhus Universitet

Aarhus C, Danmark

14 apr. 20149 maj 2014

Institut for Biomedicin - Forskning og uddannelse, Øst

Aarhus Universitet

Aarhus C, Danmark

17 dec. 201311 apr. 2014

Institut for Biomedicin - Human Genetik

Aarhus Universitet

Aarhus C, Danmark

29 jul. 201117 dec. 2013

Exchange Student

Institut for Human Genetik

Aarhus Universitet

Aarhus C, Danmark

15 jul. 200830 nov. 2008

Publikationer

FcRn overexpression in human cancer drives albumin recycling and cell growth: a mechanistic basis for exploitation in targeted albumin-drug designs

Larsen, M. T., Mandrup, O. A., Schelde, K. K., Luo, Y., Sørensen, K. D., Dagnæs-Hansen, F., Cameron, J., Stougaard, M., Steiniche, T. & Howard, K. A., jun. 2020, I : Journal of Controlled Release. 322, s. 53-63 11 s.

A single-cell approach to engineer CD8+ T cells targeting cytomegalovirus

Wang, F., Xu, Q., Zhuang, Z., Li, Z., Gao, Q., Huang, Y., Luo, Y., Zhang, X., Zhu, L. & Chao, C-C., 25 maj 2020, I : Cellular & molecular immunology.

Single-Cell RNA Sequencing Maps Endothelial Metabolic Plasticity in Pathological Angiogenesis

Rohlenova, K., Goveia, J., García-Caballero, M., Subramanian, A., Kalucka, J., Treps, L., Falkenberg, K. D., de Rooij, L. P. M. H., Zheng, Y., Lin, L., Sokol, L., Teuwen, L-A., Geldhof, V., Taverna, F., Pircher, A., Conradi, L-C., Khan, S., Stegen, S., Panovska, D., De Smet, F., Staal, F. J. T., Mclaughlin, R. J., Vinckier, S., Van Bergen, T., Ectors, N., De Haes, P., Wang, J., Bolund, L., Schoonjans, L., Karakach, T. K., Yang, H., Carmeliet, G., Liu, Y., Thienpont, B., Dewerchin, M., Eelen, G., Li, X., Luo, Y. & Carmeliet, P., apr. 2020, I : Cell Metabolism. 31, 4, s. 862-877.e14 30 s.

Single-Cell Transcriptome Atlas of Murine Endothelial Cells

Kalucka, J., de Rooij, L. P. M. H., Goveia, J., Rohlenova, K., Dumas, S. J., Meta, E., Conchinha, N. V., Taverna, F., Teuwen, L-A., Veys, K., García-Caballero, M., Khan, S., Geldhof, V., Sokol, L., Chen, R., Treps, L., Borri, M., de Zeeuw, P., Dubois, C., Karakach, T. K., Falkenberg, K. D., Parys, M., Yin, X., Vinckier, S., Du, Y., Fenton, R. A., Schoonjans, L., Dewerchin, M., Eelen, G., Thienpont, B., Lin, L., Bolund, L., Li, X., Luo, Y. & Carmeliet, P., feb. 2020, I : Cell. 180, 4, s. 764-779.e20 36 s.

A network-based algorithm for the identification of moonlighting noncoding RNAs and its application in sepsis

Liu, X., Xu, Y., Wang, R., Liu, S., Wang, J., Luo, Y., Leung, K-S. & Cheng, L., 31 jan. 2020, I : Briefings in bioinformatics.

GNL-Scorer: A generalized model for predicting CRISPR on-target activity by machine learning and featurization

Wang, J., Xiang, X., Bolund, L., Zhang, X., Cheng, L. & Luo, Y., 3 jan. 2020, I : Molecular and Cellular Biology.

An overview and metanalysis of Machine and Deep Learning-Based CRISPR gRNA Design Tools

Wang, J., Zhang, X., Cheng, L. & Luo, Y., jan. 2020, I : RNA Biology. 17, 1, s. 13-22 10 s.

Identification and functional characterization of mutations in LPL gene causing severe hypertriglyceridaemia and acute pancreatitis

Han, P., Wei, G., Cai, K., Xiang, X., Deng, W. P., Li, Y. B., Kuang, S., Dong, Z., Zheng, T., Luo, Y., Liu, J., Guan, Y., Li, C., Dey, S. K., Liao, Z. & Banerjee, S., jan. 2020, I : Journal of Cellular and Molecular Medicine (Online). 24, 2, s. 1286-1299

Single-Cell RNA Sequencing Reveals Renal Endothelium Heterogeneity and Metabolic Adaptation to Water Deprivation

Dumas, S. J., Meta, E., Borri, M., Goveia, J., Rohlenova, K., Conchinha, N. V., Falkenberg, K., Teuwen, L-A., de Rooij, L., Kalucka, J., Chen, R., Khan, S., Taverna, F., Lu, W., Parys, M., De Legher, C., Vinckier, S., Karakach, T. K., Schoonjans, L., Lin, L., Bolund, L., Dewerchin, M., Eelen, G., Rabelink, T. J., Li, X., Luo, Y. & Carmeliet, P., jan. 2020, I : Journal of the American Society of Nephrology : JASN. 31, 1, s. 118-138 21 s.

An Integrated Gene Expression Landscape Profiling Approach to Identify Lung Tumor Endothelial Cell Heterogeneity and Angiogenic Candidates

Goveia, J., Rohlenova, K., Taverna, F., Treps, L., Conradi, L-C., Pircher, A., Geldhof, V., de Rooij, L. P. M. H., Kalucka, J., Sokol, L., García-Caballero, M., Zheng, Y., Qian, J., Teuwen, L-A., Khan, S., Boeckx, B., Wauters, E., Decaluwé, H., De Leyn, P., Vansteenkiste, J., Weynand, B., Sagaert, X., Verbeken, E., Wolthuis, A., Topal, B., Everaert, W., Bohnenberger, H., Emmert, A., Panovska, D., De Smet, F., Staal, F. J. T., Mclaughlin, R. J., Impens, F., Lagani, V., Vinckier, S., Mazzone, M., Schoonjans, L., Dewerchin, M., Eelen, G., Karakach, T. K., Yang, H., Wang, J., Bolund, L., Lin, L., Thienpont, B., Li, X., Lambrechts, D., Luo, Y. & Carmeliet, P., 2020, I : Cancer Cell. 37, 1, s. 21-36.e13 29 s.

An atlas of the protein-coding genes in the human, pig, and mouse brain

Sjöstedt, E., Zhong, W., Fagerberg, L., Karlsson, M., Mitsios, N., Adori, C., Oksvold, P., Edfors, F., Limiszewska, A., Hikmet, F., Huang, J., Du, Y., Lin, L., Dong, Z., Yang, L., Liu, X., Jiang, H., Xu, X., Wang, J., Yang, H., Bolund, L., Mardinoglu, A., Zhang, C., von Feilitzen, K., Lindskog, C., Pontén, F., Luo, Y., Hökfelt, T., Uhlén, M. & Mulder, J., 2020, I : Science. 367, 6482, 5947.

Haplotyping by CRISPR-mediated DNA circularization (CRISPR-hapC) broadens allele-specific gene editing

Yu, J., Xiang, X., Huang, J., Liang, X., Pan, X., Dong, Z., Petersen, T. S., Qu, K., Yang, L., Zhao, X., Li, S., Zheng, T., Xu, Z., Liu, C., Han, P., Xu, F., Yang, H., Liu, X., Zhang, X., Bolund, L., Luo, Y. & Lin, L., 2020, I : Nucleic Acids Research. 48, 5, 13 s., e25.

Modelling of pancreatic cancer biology: transcriptomic signature for 3D PDX-derived organoids and primary cell line organoid development

Nelson, S. R., Zhang, C., Roche, S., O'Neill, F., Swan, N., Luo, Y., Larkin, A., Crown, J. & Walsh, N., 2020, I : Scientific Reports. 10, 1, 10 s., 2778.

Genetic Protection Modifications: Moving Beyond the Binary Distinction Between Therapy and Enhancement for Human Genome Editing

Mikkelsen, R. B., Frederiksen, H. R. S., Gjerris, M., Holst, B., Hyttel, P., Luo, Y., Freude, K. & Sandøe, P., dec. 2019, I : The CRISPR Journal. 2, 6, s. 362-369 8 s.

Single-Cell Transcriptome Analysis of Uniparental Embryos Reveals Parent-of-Origin Effects on Human Preimplantation Development

Leng, L., Sun, J., Huang, J., Gong, F., Yang, L., Zhang, S., Yuan, X., Fang, F., Xu, X., Luo, Y., Bolund, L., Peters, B. A., Lu, G., Jiang, T., Xu, F. & Lin, G., 7 nov. 2019, I : Cell Stem Cell. 25, 5, s. 697-712.e6

The metabolic engine of endothelial cells

Falkenberg, K. D., Rohlenova, K., Luo, Y. & Carmeliet, P., okt. 2019, I : Nature Metabolism. 1, 10, s. 937-946 10 s.

Double-strand breaks in ribosomal RNA genes activate a distinct signaling and chromatin response to facilitate nucleolar restructuring and repair

Korsholm, L. M., Gál, Z., Lin, L., Quevedo, O., Ahmad, D. A., Dulina, E., Luo, Y., Bartek, J. & Larsen, D. H., 5 sep. 2019, I : Nucleic Acids Research. 47, 15, s. 8019-8035 17 s.

Refining CRISPR-based genome and epigenome editing off-targets

Luo, Y., aug. 2019, I : Cell Biology and Toxicology. 35, 4, s. 281-283 3 s.

LION: a simple and rapid method to achieve CRISPR gene editing

Xiang, X., Luo, L., Nodzyński, M., Li, C., Han, P., Dou, H., Petersen, T. S., Liang, X., Pan, X., Qu, K., Yang, L., Dang, Y., Liu, X., Bolund, L., Zhang, X., Tong, G., Xing, Y., Luo, Y. & Lin, L., jul. 2019, I : Cellular and Molecular Life Sciences. 76, 13, s. 2633-2645 13 s.

CRISPR/Cas9-Mediated Gene Tagging: A Step-by-Step Protocol

Xiang, X., Li, C., Chen, X., Dou, H., Li, Y., Zhang, X. & Luo, Y., 2019, CRISPR gene editing. Luo, Y. (red.). New York: Humana Press, s. 255-269 15 s. (Methods in Molecular Biology, Bind 1961).

Functional Evaluation of CRISPR Activity by the Dual-Fluorescent Surrogate System: C-Check

Lin, L. & Luo, Y., 2019, CRISPR Gene Editing: Methods and Protocols. Luo, Y. (red.). Springer Science+Business Media, s. 67-77 11 s. (Methods in Molecular Biology, Bind 1961).

Population Genomics of an Obligately Halophilic Basidiomycete Wallemia ichthyophaga

Gostinčar, C., Sun, X., Zajc, J., Fang, C., Hou, Y., Luo, Y., Gunde-Cimerman, N. & Song, Z., 2019, I : Frontiers in Microbiology. 10, 12 s.

Rapid and Efficient Gene Deletion by CRISPR/Cas9

Neldeborg, S., Lin, L., Stougaard, M. & Luo, Y., 2019, CRISPR Gene Editing: Methods and Protocols. Humana Press, s. 233-247 15 s. (Methods in Molecular Biology, Bind 1961).

Tracking CRISPR's Footprints

Lin, L. & Luo, Y., 2019, CRISPR Gene Editing: Methods and Protocols. Luo, Y. (red.). Springer Science+Business Media, s. 13-28 16 s. (Methods in Molecular Biology, Bind 1961).

CRISPR-C: circularization of genes and chromosome by CRISPR in human cells

Møller, H. D., Lin, L., Xiang, X., Petersen, T. S., Huang, J., Yang, L., Kjeldsen, E., Jensen, U. B., Zhang, X., Liu, X., Xu, X., Wang, J., Yang, H., Church, G. M., Bolund, L., Regenberg, B. & Luo, Y., 14 dec. 2018, I : Nucleic Acids Research. 46, 22, s. e131

STAT3 associates with vacuolar H+-ATPase and regulates cytosolic and lysosomal pH

Liu, B., Palmfeldt, J., Lin, L., Colaço, A., Clemmensen, K. K. B., Huang, J., Xu, F., Liu, X., Maeda, K., Luo, Y. & Jäättelä, M., okt. 2018, I : Cell Research. 28, 10, s. 996–1012 17 s.

Nrf2 negatively regulates STING indicating a link between antiviral sensing and metabolic reprogramming

Olagnier, D., Brandtoft, A. M., Gunderstofte, C., Villadsen, N. L., Krapp, C., Thielke, A. L., Laustsen, A., Peri, S., Hansen, A. L., Bonefeld, L., Thyrsted, J., Bruun, V., Iversen, M. B., Lin, L., Artegoitia, V. M., Su, C., Yang, L., Lin, R., Balachandran, S., Luo, Y., Nyegaard, M., Marrero, B., Goldbach-Mansky, R., Motwani, M., Ryan, D. G., Fitzgerald, K. A., O'Neill, L. A., Hollensen, A. K., Damgaard, C. K., de Paoli, F. V., Bertram, H. C., Jakobsen, M. R., Poulsen, T. B. & Holm, C. K., 29 aug. 2018, I : Nature Communications. 9, 1, 3506.

Simple method for assembly of CRISPR synergistic activation mediator gRNA expression array

Vad-Nielsen, J., Nielsen, A. L. & Luo, Y., 20 maj 2018, I : Journal of Biotechnology. 274, s. 54-57 4 s.

Genome-wide determination of on-target and off-target characteristics for RNA-guided DNA methylation by dCas9 methyltransferases

Lin, L., Liu, Y., Xu, F., Huang, J., Daugaard, T. F., Petersen, T. S., Hansen, B., Ye, L., Zhou, Q., Fang, F., Yang, L., Li, S., Fløe, L., Jensen, K. T., Shrock, E., Chen, F., Yang, H., Wang, J., Liu, X., Xu, X., Bolund, L., Nielsen, A. L. & Luo, Y., 1 mar. 2018, I : GigaScience. 7, 3, s. 1-19 19 s.

Central and peripheral nervous system progenitors derived from human pluripotent stem cells reveal a unique temporal and cell-type specific expression of PMCAs

Chen, M., Laursen, S. H., Habekost, M., Knudsen, C. H., Buchholdt, S. H., Huang, J., Xu, F., Liu, X., Bolund, L., Luo, Y., Nissen, P., Febbraro, F. & Denham, M., 6 feb. 2018, I : Frontiers in Cell and Developmental Biology. 6, 10 s., 5.

Inactivation of porcine endogenous retrovirus in pigs using CRISPR-Cas9

Niu, D., Wei, H-J., Lin, L., George, H., Wang, T., Lee, I-H., Zhao, H-Y., Kan, Y., Shrock, E., Lesha, E., Wang, G., Luo, Y., Qing, Y., Jiao, D., Zhao, H., Zhou, X., Wang, S., Wei, H., Güell, M., Church, G. M. & Yang, L., 22 sep. 2017, I : Science. 357, 6357, s. 1303-1307 5 s.

Chromatin accessibility and guide sequence secondary structure affect CRISPR-Cas9 gene editing efficiency

Jensen, K. T., Fløe, L., Petersen, T. S., Huang, J., Xu, F., Bolund, L., Luo, Y. & Lin, L., 5 jun. 2017, I : FEBS Letters. 591, 13, s. 1892-1901 10 s.

RNA-Guided Activation of Pluripotency Genes in Human Fibroblasts

Xiong, K., Zhou, Y., Blichfeld, K. A., Hyttel, P., Bolund, L., Freude, K. K. & Luo, Y., jun. 2017, I : Cellular reprogramming. 19, 3, s. 189-198 10 s.

IGF1R depletion facilitates MET-amplification as mechanism of acquired resistance to erlotinib in HCC827 NSCLC cells

Hussmann, D., Madsen, A. T., Jakobsen, K. R., Luo, Y., Sorensen, B. S. & Nielsen, A. L., 18 mar. 2017, I : OncoTarget. 8

Induced pluripotent stem cells derived from a patient with autosomal dominant familial neurohypophyseal diabetes insipidus caused by a variant in the AVP gene

Toustrup, L. B., Zhou, Y., Kvistgaard, H., Gregersen, N., Rittig, S., Aagaard, L., Corydon, T. J., Luo, Y. & Christensen, J. H., mar. 2017, I : Stem Cell Research. 19, s. 37-42 6 s.

Mitochondrial Spare Respiratory Capacity Is Negatively Correlated With Nuclear Reprogramming Efficiency

Zhou, Y., Al-Saaidi, R. A., Guerra, P. F., Freude, K. K., Olsen, R. K. J., Jensen, U. B., Gregersen, N., Hyttel, P., Bolund, L., Aagaard, L., Bross, P. & Luo, Y., feb. 2017, I : Stem Cells and Development. 26, 3, s. 166-176 11 s.

Evaluation of porcine stem cells competence for somatic cell nuclear transfer and production of cloned animals

Secher, J., Liu, Y., Petkov, S., Luo, Y., Li, D., Hall, V. J., Schmidt, M., Callesen, H., Bentzon, J. F., Sørensen, C. B., Freude, K. K. & Hyttel, P., 2017, I : Animal Reproduction Science. 178, s. 40-49

Fusion of SpCas9 to E.coli Rec A protein enhances CRISPR-Cas9 mediated gene knockout in mammalian cells

Lin, L., Petersen, T. S., Jensen, K. T., Bolund, L., Kühn, R. & Luo, Y., 2017, I : Journal of Biotechnology. 247, s. 42-29 8 s.

Patient iPSC-Derived Neurons for Disease Modeling of Frontotemporal Dementia with Mutation in CHMP2B

Zhang, Y., Schmid, B., Nikolaisen, N. K., Rasmussen, M. A., Aldana, B. I., Agger, M., Calloe, K., Stummann, T. C., Larsen, H. M., Nielsen, T. T., Huang, J., Xu, F., Liu, X., Bolund, L., Meyer, M., Bak, L. K., Waagepetersen, H. S., Luo, Y., Nielsen, J. E., Holst, B., Clausen, C., Hyttel, P., Freude, K. K. & FReJA Consortium, 2017, I : Stem Cell Reports. 8, 3

Systematic in vitro and in vivo characterization of Leukemia-inhibiting factor- and Fibroblast growth factor-derived porcine induced pluripotent stem cells

Secher, J. O., Ceylan, A., Mazzoni, G., Mashayekhi, K., Li, T., Muenthaisong, S., Nielsen, T. T., Li, D., Li, S., Petkov, S., Cirera, S., Luo, Y., Thombs, L., Kadarmideen, H. N., Dinnyes, A., Bolund, L., Roelen, B. A. J., Schmidt, M., Callesen, H., Hyttel, P. & Freude, K. K., 2017, I : Molecular Reproduction and Development. 84, 3, s. 229-245 17 s.

The Effects of Voluntary Physical Exercise-Activated Neurotrophic Signaling in Rat Hippocampus on mRNA Levels of Downstream Signaling Molecules

Sølvsten, C., Daugaard, T. F., Luo, Y., de Paoli, F. V., Christensen, J. H. & Nielsen, A. L., 2017, I : Journal of Molecular Neuroscience. 62, 2, s. 142-153

A Golden Gate-based Protocol for Assembly of Multiplexed gRNA Expression Arrays for CRISPR/Cas9

Vad-Nielsen, J., Lin, L., Jensen, K. T., Nielsen, A. L. & Luo, Y., 5 dec. 2016, I : Bio-protocol. 6, 23, e2059.

Generation of induced pluripotent stem cells (iPSCs) stably expressing CRISPR-based synergistic activation mediator (SAM)

Xiong, K., Zhou, Y., Hyttel, P., Bolund, L., Freude, K. K. & Luo, Y., 17 nov. 2016, I : Stem Cell Research. 17, 3, s. 665-669 5 s.

CRISPR-mediated multiplexed genetic manipulation

Lin, L., Vad-Nielsen, J. & Luo, Y., 15 nov. 2016, I : OncoTargets and Therapy.

The CRISPR-Cas9 Minipig

Berthelsen, M. F., Møller, S., Callesen, H., Dagnæs-Hansen, F., Luo, Y., Jakobsen, J. E. & Thomsen, M. K., 22 sep. 2016. 1 s.

Golden Gate Assembly of CRISPR gRNA expression array for simultaneously targeting multiple genes

Vad-Nielsen, J., Lin, L., Bolund, L., Nielsen, A. L. & Luo, Y., 13 maj 2016, I : Cellular and Molecular Life Sciences. 73, 22, s. 4315–4325

Pig model for diabetes

Luo, Y. & Bolund, L., 3 mar. 2016, Prioritetsdato 28 aug. 2014, Prioritetsnr. WO2016029919 A1

Enhanced genome editing in mammalian cells with a modified dual-fluorescent surrogate system

Zhou, Y., Liu, Y., Hussmann, D., Brøgger, P., Al-Saaidi, R. A., Tan, S., Lin, L., Petersen, T. S., Zhou, G. Q., Bross, P., Aagaard, L., Klein, T., Rønn, S. G., Pedersen, H. D., Bolund, L., Nielsen, A. L., Sørensen, C. B. & Luo, Y., 11 jan. 2016, I : Cellular and Molecular Life Sciences. 73, 13, s. 2543-63 21 s.

Genetically modified pig models for neurodegenerative disorders

Holm, I. E., Alstrup, A. K. O. & Luo, Y., jan. 2016, I : Journal of Pathology. 238, 2, s. 267-87 21 s.

Precision Epigenome Editing – Promise and Challenge

Fløe, L. & Luo, Y., 2016, I : Biozoom. 4

Targeted, homology-driven gene insertion in stem cells by ZFN-loaded 'all-in-one' lentiviral vectors

Cai, Y., Laustsen, A., Zhou, Y., Sun, C., Anderson, M. V., Li, S., Uldbjerg, N., Luo, Y., Jakobsen, M. R. & Mikkelsen, J. G., 2016, I : eLife. 5

EWS and FUS bind a subset of transcribed genes encoding proteins enriched in RNA regulatory functions

Luo, Y., Friis, J. B., Fernandes, A. M., Li, S., Fryland, T., Børglum, A., Bolund, L. & Nielsen, A. L., nov. 2015, I : BMC Genomics. 16, 17 s.

The Epigenetic Reprogramming Roadmap in Generation of iPSCs from Somatic Cells

Brix, J., Zhou, Y. & Luo, Y., okt. 2015, I : Journal of Genetics and Genomics.

Towards personalized regenerative cell therapy: Mesenchymal stem cells derived from human induced pluripotent stem cells

Lin, L., Bolund, L. & Luo, Y., 23 jul. 2015, I : Current Stem Cell Research & Therapy.

Mesenchymal stem cells derived from human induced pluripotent stem cells retain adequate osteogenicity and chondrogenicity but less adipogenicity

Kang, R., Zhou, Y., Tan, S., Zhou, G., Aagaard, L., Xie, L., Bünger, C., Bolund, L. & Luo, Y., 2015, I : Stem Cell Research & Therapy. 6, 1, s. 144

Targeted Porcine Genome Engineering with TALENs

Luo, Y., Lin, L., Golas, M. M., Sørensen, C. B. & Bolund, L., 2015, Somatic Genome Manipulation : Advances, Methods and Applications. Springer New York, s. 17-33

Clock-controlled StAR's expression and corticosterone production contribute to the endotoxemia immune response

Wang, J., Luo, Y., Wang, K., Wang, Y., Zhang, X., Teng, H. & Sun, Z., 25 nov. 2014, I : Chronobiology International. s. 1-10 10 s.

Efficient construction of rAAV-based gene targeting vectors by Golden Gate cloning

Luo, Y., Lin, L., Bolund, L. & Sørensen, C. B., maj 2014, I : BioTechniques. 56, 5, s. 263-8 6 s.

Effects of high hydrostatic pressure on genomic expression profiling of porcine parthenogenetic activated and cloned embryos

Lin, L., Luo, Y., Sørensen, P., Prætorius, H., Vajta, G., Callesen, H., Pribenszky, C., Bolund, L. & Kristensen, T. N., 2014, I : Reproduction, Fertility and Development. 26, s. 469-484 16 s.

Efficient genome engineering using rAAV and TALENs in pigs

Luo, Y., Viuff, B. M., Lin, L., Li, R., Schmidt, M., Rønn, S. G., Pedersen, H. D., Callesen, H., Sørensen, C. B., Brünner, N., Klein, T. & Bolund, L., 2014, I : Transgenic Research. 23, 1, s. 189-190

Oesteogenesis of Human Induced Pluripotent Stem Cells Derived Mesenchymal Stem Cells on hydroxyapatite contained Nanofibers

Kang, R., Luo, Y., Zou, L., Xie, L., Lysdahl, H., Jiang, X., Chen, C., Bolund, L., Chen, M., Besenbacher, F. & Bunger, C. E., 2014, I : R S C Advances. 4, 11, s. 5734-5739

A simple method for deriving functional MSCs and applied for osteogenesis in 3D scaffolds

Zou, L., Luo, Y., Chen, M., Wang, G., Ding, M., Petersen, C. C., Kang, R., Dagnaes-Hansen, F., Zeng, Y., Lv, N., Ma, Q., Le, D. Q. S., Besenbacher, F., Bolund, L., Jensen, T. G., Kjems, J., Pu, W. T. & Bünger, C., 22 jul. 2013, I : Scientific Reports. 3, 10 s., 2243.

Gene Expression Responses to FUS, EWS, and TAF15 Reduction and Stress Granule Sequestration Analyses Identifies FET-Protein Non-Redundant Functions

Blechingberg, J., Luo, Y., Bolund, L., Damgaard, C. K. & Nielsen, A. L., 25 sep. 2012, I : P L o S One. 7, 9, s. e46251 15 s.

Development of BRCA1 Knockout Pigs and Transcriptome Studies of Disease Progression

Luo, Y., mar. 2012

Genetically modified pigs for biomedical research

Luo, Y., Lin, L., Bolund, L., Jensen, T. G. & Sørensen, C. B., 2012, I : Journal of Inherited Metabolic Disease. 35, 4, s. 695-713

Pig gene knockout by rAAV-mediated homologous recombination: comparison of BRCA1 gene knockout efficiency in Yucatan and Göttingen fibroblasts with slightly different target sequences

Luo, Y., Bolund, L. & Sørensen, C. B., 2012, I : Transgenic Research. 21, s. 671-676

Regulation of Peripheral Clock to Oscillation of Substance P Contributes to Circadian Inflammatory Pain

Zhang, J., Li, H., Teng, H., Zhang, T., Luo, Y., Zhao, M., Li, Y-Q. & Sun, Z. S., 2012, I : Anesthesiology News. 117, 1

Targeted Genome Editing by Recombinant Adeno-Associated Virus (rAAV) Vectors for Generating Genetically Modified Pigs

Luo, Y., Kofod-Olsen, E., Christensen, R., Sørensen, C. B. & Bolund, L., 2012, I : Journal of Genetics and Genomics. 39, 6, s. 269-74 6 s.

Amino acid-induced gene expression profiling in clonal β-cell line INS-1E cells

Liu, Z., Luo, Y., Jeppesen, P. B., Gregersen, S. & Hermansen, K., 1 feb. 2011, I : Diabetes - Metabolism: Research and Reviews (Print Edition). 27, 2, s. 120-76 57 s.

An improved PCR strategy for fast screening of specific and random integrations in rAAV-mediated gene targeted cell clones

Luo, Y., Bolund, L. & Sørensen, C. B., 2011, I : BMC Research Notes. 4, s. 246

Comparison of gene expression and genome-wide DNA methylation profiling between phenotypically normal cloned pigs and conventionally bred controls

Fei, G., Luo, Y., Li, S., Li, J., Lin, L., Nielsen, A. L., Sørensen, C. B., Vajta, G., Wang, J., Zhang, X., Du, Y., Yang, H. & Bolund, L., 2011, I : P L o S One. 6, 10, s. e25901

DNA Methylation in Peripheral Blood Cells of Pigs Cloned by Somatic Cell Nuclear Transfer

Gao, F., Li, S., Lin, L., Li, J., Luo, Y., Zhang, X., Nielsen, A. L. & Bolund, L., 2011, I : Cellular Reprogramming. 13, 4, s. 307-314

High efficiency of BRCA1 knockout using rAAV-mediated gene targeting: developing a pig model for breast cancer

Luo, Y., Li, J., Liu, Y., Lin, L., Du, Y., Li, S., Yang, H., Vajta, G., Callesen, H., Bolund, L. & Sørensen, C. B., 2011, I : Transgenic Research. 20, s. 975-988

Expression Profiling Reveals A Positive Regulation by Mper2 on Circadian Rhythm of Cytotoxicity Receptors: Ly49c and Nkg2d

Luo, Y., Tian, W., Cai, L., Wang, Y., Zhang, J., Teng, H., Du, J. & Sun, Z. S., 2009, I : Chronobiology International. 26, 8, s. 1514-1544

Aktiviteter

The Roslin Institute

Yonglun Luo (Gæsteforsker)

15 apr. 201315 jun. 2013

ESOF2012

Yonglun Luo (Deltager)

11 jul. 201216 jul. 2012

Development of BRCA1 Knockout Pigs and Transcriptome Studies of Disease Progression

Yonglun Luo (Oplægsholder)

13 jan. 2012

2nd International Symposium on Breast Cancer Prevention

Yonglun Luo (Oplægsholder)

9 okt. 201111 okt. 2011

MEDICINSKGENETIK

Yonglun Luo (Andet)

6 jan. 201112 jan. 2011

Transgenesis and Gene Targeting using Recombinant Adeno-Associated Virus (rAAV): External PhD course

Yonglun Luo (Foredragsholder)

okt. 2010nov. 2010

CSH - Asia Meeting: Human Genetics & Genomics

Yonglun Luo (Deltager)

6 sep. 201010 sep. 2010

American Society of Gene Therapy 13th Annual Meeting

Yonglun Luo (Deltager)

19 maj 201022 maj 2010